A src-like kinase activates outwardly rectifying chloride channels in CFTR-defective lymphocytes

FASEB Journal

Volumn 15, Issue 6, 2001, Pages 927-931

  Lepple Wienhues, Albecht ^a   Wieland, Ulrich ^a   Laun, Tilmann ^b   Heil, Luzia ^b   Stern, Martin ^a   Lang, Florian ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Universität Tübingen ^*

Author keywords

Cell volume; Cyclic adenosine monophosphate; Cystic fibrosis; Human lymphocytes; Tyrosine kinase

Indexed keywords

CHLORIDE CHANNEL; CYCLIC AMP; PROTEIN P56; PROTEIN TYROSINE KINASE;

ARTICLE; CELL SWELLING; CHLORIDE CONDUCTANCE; CONTROLLED STUDY; CYSTIC FIBROSIS; GENE MUTATION; HUMAN; HUMAN CELL; LYMPHOCYTE; MEMBRANE CONDUCTANCE; PRIORITY JOURNAL;

CHLORIDE CHANNELS; CYCLIC AMP; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ELECTROPHYSIOLOGY; HUMANS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); LYMPHOCYTES; OSMOLAR CONCENTRATION; SRC-FAMILY KINASES;

EID: 0035074188     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00-0264com     Document Type: Article

References (51)

1. Identification of the cystic fibrosis gene: Genetic analysis
2. Abnormal regulation of ion channels in cystic fibrosis epithelia
3. Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
4. Demonstration that CFTR is a chloride channel by alteration of its anion selectivity
5. Chloride channels in the apical membrane of normal and cystic fibrosis airway and intestinal epithelia
6. Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel
7. cAMP-stimulated ion currents in Xenopus oocytes expressing Cftr cRna
8. Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes
9. - channel in CHO cells stably expressing the cystic fibrosis gene
10. - conductance of Ht29 cells
11. + conductance in cystic fibrosis
12. + currents by intracellular domains of the cystic fibrosis transmembrane conductance regulator
13. Regulation of epithelial ion channels by the cystic fibrosis transmembrane conductance regulator
14. + transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation
15. Abnormal apical cell membrane in cystic fibrosis respiratory epithelium. An in vitro electrophysiologic analysis
16. Abnormal ion permeation through cystic fibrosis respiratory epithelium
17. cAMP stimulates bicarbonate secretion across normal, but not cystic fibrosis airway epithelia
18. Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro
19. - channel function
20. Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium
21. - channel by specific protein kinases and protein phosphatases
22. Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells
23. Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis
24. Calcium and cAMP activate different chloride channels in the apical membrane of normal and cystic fibrosis epithelia
25. Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice
26. Chloride secretion in response to guanylin in colonic epithelial from normal and transgenic cystic fibrosis mice
27. - secretion
28. An animal model for cystic fibrosis made by gene targeting
29. Production of a severe cystic fibrosis mutation in mice by gene targeting
30. Analysis of ClC-2 channels as an alternative pathway for chloride conduction in cystic fibrosis airway cells
31. An apical-membrane chloride channel in human tracheal epithelium
32. Phosphorylation fails to activate chloride channels from cystic fibrosis airway cells
33. Phosphorylation-dependent regulation of apical membrane chloride channels in normal and cystic fibrosis airway epithelium
34. A cAMP-regulated chloride channel in lymphocytes that is affected in cystic fibrosis
35. CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship
36. Chloride channels activated by osmotic stress in T lymphocytes
37. Properties and regulations of chloride channels in cystic fibrosis and normal airway cells
38. - channels in normal and cystic fibrosis epithelial cells
39. Swelling-induced chloride-sensitive current in canine atrial cells revealed by whole-cell patch-clamp method
40. - channels
41. The tyrosine kinase p56lck mediates activation of swelling-induced chloride channels in lymphocytes
42. Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes
43. Tyrosine protein kinase inhibitors prevent activation of cardiac swelling-induced chloride current
44. Protein tyrosine phosphorylation is involved in osmoregulation of ionic conductances
45. Regulation of a swelling-activated chloride current in bovine endothelium by protein tyrosine phosphorylation and G proteins
46. Membrane chloride conductance and capacitance in Jurkat T lymphocytes during osmotic swelling
47. Human lymphocytes transcribe the cystic fibrosis transmembrane conductance regulator gene and exhibit CF-defective cAMP-regulated chloride current
48. Transfection of wild-type CFTR into cystic fibrosis lymphocytes restores chloride conductance at G1 of the cell cycle
49. Functional significance of cell volume regulatory mechanisms
50. The tyrosine kinase p60c-src regulates the fast gate of the cystic fibrosis transmembrane conductance regulator chloride channel
51. Rates of diffusional exchange between small cells and a measuring patch pipette