Blood pressure and heart rate are increased by AF-DX 116, a selective M2 antagonist, in autonomic imbalanced and hypotensive rats caused by repeated cold stress

Japanese Journal of Pharmacology

Volumn 85, Issue 3, 2001, Pages 313-321

  Hata, T ^a   Itoh, E ^a   Funakami, Y ^a   Ishida, K ^a   Uchida, S ^a  

^a KINKI UNIVERSITY   (Japan)

Author keywords

AF DX 116; Blood pressure; Hypotension; M2 antagonist; Stress

Indexed keywords

ATROPINE; OTENZEPAD; PIRENZEPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTONOMIC DYSFUNCTION; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; CHOLINERGIC SYSTEM; CHRONOTROPISM; COLD STRESS; COMPARATIVE STUDY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE CLASSIFICATION; DOSE RESPONSE; DRUG EFFECT; DYSAUTONOMIA; HEART MUSCLE; HEART RATE; HYPOTENSION; MALE; NONHUMAN; PRESSOR RESPONSE; RAT; SYMPATHETIC NERVE; SYSTOLIC BLOOD PRESSURE;

EID: 0035073787     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.85.313     Document Type: Article

References (41)

1. Studies in man on the relationship of adrenergic correlates to pressor responsivity
2. Acute and conditioned blood pressure changes in relation tio social and psychosocial stimuli in rats
3. The borderline hypertensive rat: A model for studying the mechanisms of environmentally induced hypertension
4. Role of sympathoadrenomedullary system in cardiovascular response to stress in rats
5. Bilateral renal denervation can prevent the development of stress-induced hypertension in the borderline hypertensive rat
6. Psychosocial stress can induce chronic hypertension in normotensive strains of rats
7. Cold-induced stress stimulates the sympathetic nervous system, causing hypertension and proteinuria in rats
8. Stress state caused by alternation of rhythm in environmental temperature, and the functional disorders in mice and rats
9. Changes of blood pressure and regional blood flow in SART rats and drug actions on these changes
10. Body temperature, shivering, blood pressure and heart rate during a standard cold stress in Australia and Antarctica
11. The responses of skin blood flow, mean arterial pressure and R-R interval induced by cold stimulation with cold wind and ice water
12. Stress and hypertension: Role of serum, red cell and tissue electrolytes
13. Testing methods for vegetative syndrome in the rat and effects of neurotropin and other drugs
14. Electrocorticogram in rats loaded with SART stress (repeated cold stress)
15. Decrease in pain threshold in SART stressed mice
16. Changes in platelet count and related parameters in SART-stressed mice and the action of administered neurotropin
17. Changes of the function in the heart of SART stressed (repeated cold stressed) mice and the action of neurotropin on these changes
18. Changes of tissue blood flow in mice loaded with SART (repeated cold) stress or restraint and water immersion stress and the effect of administered neurotropin
19. Total acetylcholine content, and activities of choline acetyltransferase and acetylcholinesterase in brain and duodenum of SART-stressed (repeated cold-stressed) rat
20. Decrease in muscarinic acetylcholine receptors in the small intestine of mice subjected to repeated cold stress
21. 2 cholinoceptors involved in cholinergic hypertension
22. Muscarinic receptor subtype involvement in brain cholinergic stimulation by intracerebroventricular neostigmine in sinoaortic denervated rats
23. Experimental studies on optimal conditions of loading SART stress (repeated cold stress) upon animals
24. Pathophysiological changes associated with stress-induced hypertension in the borderline hypertensive rat
25. Relationship between exposure to stress and development of hypertension
26. The effect of endogenous opioids on blood pressure during stress
27. Central regulation of stress responses: Regulation of the autonomic nervous system and visceral function by corticotropin releasing factor-41
28. Mineralocorticoid and glycyrrhizic acid block stress induced hypotension in rats
29. Regulation of a putative neurotransmitter effect of corticotropin-releasing factor: Effects of adrenalectomy
30. Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors
31. Binding profile of a novel cardioselective muscarinic receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat
32. Modulation of pressor response elicited by carbachol and electrical stimulation of the amygdala by muscarinic antagonists in conscious rats
33. Characterization of the central muscarinic cholinoceptors involved in the cholinergic pressor response in anesthetized dogs
34. 2-cholinoceptors in man
35. 2 receptors with nicotinic receptors
36. Catecholamine antagonism of acetylcholine and dibutyrylguanosine 3′,5′-monophosphate in the mammalian ventricular myocardium
37. 3H]-noradrenaline from rat atria and rabbit ear artery
38. Clinical study on accentuated antagonism in the regulation of heart rate in children
39. The autonomic nervous control of heart rate in ducks during voluntary diving
40. Peripheral muscarinic control of norepinephrine release in the cardiovascular system
41. The effect of AF-DX 16, a cardioselective muscarinic antagonist, on the negative inotropic action of acetylcholine