Bioequivalence of two rimantadine tablet formulations in healthy male volunteers after single dose administration

International Journal of Clinical Pharmacology and Therapeutics

Volumn 39, Issue 4, 2001, Pages 179-184

  Chladek J ^a   Sispera, L ^a   Martinkova J ^a   Zaludek, B ^a   Sova, P ^a   Mieuda S ^a   Grim, J ^a   Cermanova J ^a   Franc, A ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Bioequivalence; Pharmacokinetics; Rimantadine

Indexed keywords

RIMANTADIN LACHEMA; RIMANTADINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CALCULATION; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DATA ANALYSIS; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG TOLERABILITY; ECONOMICS; ELECTRON CAPTURE DETECTION; ETHICS; GAS CHROMATOGRAPHY; GEOMETRY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PARAMETER; QUALITY CONTROL; RANDOMIZED CONTROLLED TRIAL; REFERENCE VALUE; STATISTICS; TABLET; TIME; VOLUNTEER;

EID: 0035073679     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP39179     Document Type: Article

References (9)

1. Pharmacokinetics of a single dose of rimantadine in young adults and children
2. Rimantadine pharmacokinetics in healthy subjects and patients with end-stage renal failure
3. Truncated AUC evaluates effectively the bioequivalence of drugs with long half-lives
4. Comparative single-dose pharmacokinetics of amantadine hydrochloride and rimantadine hydrochloride in young and elderly adults
5. Experimental, extrapolated and truncated areas under the concentration time-curve in bioequivalence trials
6. Use of antivirals in influenza in the elderly: Prophylaxis and therapy
7. Rimantadine pharmacokinetics after single and multiple doses
8. Influence of a meal on the bioavailability of rimantadine hydrochloride