-
1
-
-
0001055177
-
Antiviral activity of 1-adaman-tanamine (Amantadine)
-
Davies WL, Grunert RR, Haft RF, et al: Antiviral activity of 1-adaman-tanamine (amantadine). Science 1964;144:862-863.
-
(1964)
Science
, vol.144
, pp. 862-863
-
-
Davies, W.L.1
Grunert, R.R.2
Haft, R.F.3
-
5
-
-
0024562309
-
Resistance of influenza A virus to amantadine and rimantadine: Results of one decade of surveillance
-
Belshe RB, Burk B, Newman F, Cerruti RL, Sim IS: Resistance of influenza A virus to amantadine and rimantadine: Results of one decade of surveillance. J Infect Dis 1989; 159:430-435.
-
(1989)
J Infect Dis
, vol.159
, pp. 430-435
-
-
Belshe, R.B.1
Burk, B.2
Newman, F.3
Cerruti, R.L.4
Sim, I.S.5
-
7
-
-
0017620343
-
The relative potencies of anti-influenza compounds
-
Tisdale M, Bauer DJ: The relative potencies of anti-influenza compounds. Ann NY Acad Sci 1977; 284:254-263.
-
(1977)
Ann NY Acad Sci
, vol.284
, pp. 254-263
-
-
Tisdale, M.1
Bauer, D.J.2
-
8
-
-
0018875646
-
Plaque inhibition assay for drug susceptibility testing of influenza viruses
-
Hayden FG, Cote KM, Douglas RG: Plaque inhibition assay for drug susceptibility testing of influenza viruses. Antimicrob Agents C’hemo-thcr 1989:17:865-870.
-
(1989)
Antimicrob Agents C’hemo-thcr
, vol.17
, pp. 865-870
-
-
Hayden, F.G.1
Cote, K.M.2
Douglas, R.G.3
-
9
-
-
84977014099
-
Effect of 1-adamanta-nantinc hydrochloride (Amantadine HC1) and methyl-l-adamantathyl-aminc hydrochloride (rimantadine HCI) on transmission of influenza infection in mice
-
Schulman JL: Effect of 1-adamanta-nantinc hydrochloride (amantadine HC1) and methyl-l-adamantathyl-aminc hydrochloride (rimantadine HCI) on transmission of influenza infection in mice. Proc Soc Exp Biol Med 1968:108:1173-1178.
-
(1968)
Proc Soc Exp Biol Med
, vol.108
, pp. 1173-1178
-
-
Schulman, J.L.1
-
10
-
-
0021878483
-
Comparativesin-gle-dose pharmacokinetics of amantadine hydrochloride and rimantadine hydrochloride in young and elderly adults
-
Hayden FG, Minocha A, Spyker DA, Hoffman HE: Comparativesin-gle-dose pharmacokinetics of amantadine hydrochloride and rimantadine hydrochloride in young and elderly adults. Antimicrob Agents Chemother 1985:28:216-221.
-
(1985)
Antimicrob Agents Chemother
, vol.28
, pp. 216-221
-
-
Hayden, F.G.1
Minocha, A.2
Spyker, D.A.3
Hoffman, H.E.4
-
11
-
-
0020534168
-
Differences in side effects of amantadine hydrochloride and rimantadine hydrochloride relate to differences in pharmacokinetics
-
Hayden FG, Hoffman HE, Spyker DA: Differences in side effects of amantadine hydrochloride and rimantadine hydrochloride relate to differences in pharmacokinetics. Antimicrob Agents Chemother 1983;23:458-464.
-
(1983)
Antimicrob Agents Chemother
, vol.23
, pp. 458-464
-
-
Hayden, F.G.1
Hoffman, H.E.2
Spyker, D.A.3
-
13
-
-
0018602771
-
Amantadine kinetics in healthy young subjects after long-term dosing
-
Aoki FY, Sitar DS, Ogilvie RI: Amantadine kinetics in healthy young subjects after long-term dosing. Clin Pharmacol Thcr 1979:26: 729-736.
-
(1979)
Clin Pharmacol Thcr
, vol.26
, pp. 729-736
-
-
Aoki, F.Y.1
Sitar, D.S.2
Ogilvie, R.I.3
-
14
-
-
0021795615
-
Amantadine kinetics in healthy elderly men: Implications for influenza prevention
-
Aoki FY, Sitar DS: Amantadine kinetics in healthy elderly men: Implications for influenza prevention. Clin Pharmacol Ther 1985;37:137-144.
-
(1985)
Clin Pharmacol Ther
, vol.37
, pp. 137-144
-
-
Aoki, F.Y.1
Sitar, D.S.2
-
15
-
-
0019475566
-
Pharmacokinetics of amantadine hydrochloride in subjects with normal and impaired renal function
-
et al
-
Horadanr VW, Sharp JG, Smilack JD, et al: Pharmacokinetics of amantadine hydrochloride in subjects with normal and impaired renal function. Ann Intern Med 1981: 94:454-458.
-
(1981)
Ann Intern Med
, vol.94
, pp. 454-458
-
-
Horadanr, V.W.1
Sharp, J.G.2
Smilack, J.D.3
-
16
-
-
0023880060
-
Rimantadine pharmacokinetics in healthy subjects and patients with end-stagc renal failure
-
Capparelli EV, Stevens RC, Chow MSS, Izard M, Wills RJ: Rimantadine pharmacokinetics in healthy subjects and patients with end-stagc renal failure. Pharmacol Ther 1988: 43:536-541.
-
(1988)
Pharmacol Ther
, vol.43
, pp. 536-541
-
-
Capparelli, E.V.1
Stevens, R.C.2
Chow, M.3
Izard, M.4
Wills, R.J.5
-
17
-
-
0023635685
-
Pharmacokinetics of rimantadine hydrochloride in patients with chronic liver disease
-
Wills RJ, Belshe R, Tomlinson D, et al: Pharmacokinetics of rimantadine hydrochloride in patients with chronic liver disease. Clin Pharmacol Ther 1987:42:449-454.
-
(1987)
Clin Pharmacol Ther
, vol.42
, pp. 449-454
-
-
Wills, R.J.1
Belshe, R.2
Tomlinson, D.3
-
18
-
-
0023858220
-
T ransport of amantadine and rimantadine through the blood-brain barrier
-
Spector R: T ransport of amantadine and rimantadine through the blood-brain barrier. J Pharmacol Exp Ther 1988;244:516-519.
-
(1988)
J Pharmacol Exp Ther
, vol.244
, pp. 516-519
-
-
Spector, R.1
-
19
-
-
0019495791
-
Comparative toxicity of amantadine hydrochloride and rimantadine hydrochloride in healthy adults
-
Hayden FG, Gwaltney JM, Van dc Castle RL, Adams KF, Giordani B: Comparative toxicity of amantadine hydrochloride and rimantadine hydrochloride in healthy adults. Antimicrob Agents Chemother 1981: 19:226-233.
-
(1981)
Antimicrob Agents Chemother
, vol.19
, pp. 226-233
-
-
Hayden, F.G.1
Gwaltney, J.M.2
Van Dc Castle, R.L.3
Adams, K.F.4
Giordani, B.5
-
20
-
-
0019997609
-
A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection
-
Dolin R, Reichman RC, Madore HP, Maynard R, Linton PN, Wcb-ber-Jones J: A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection. N Engl J Med 1982:307:580-584.
-
(1982)
N Engl J Med
, vol.307
, pp. 580-584
-
-
Dolin, R.1
Reichman, R.C.2
Madore, H.P.3
Maynard, R.4
Linton, P.N.5
Wcb-Ber-Jones, J.6
-
21
-
-
0020062320
-
Double-blind study of central nervous system side-effects of amantadine. Rimantadine, and chlorpheniramine
-
Millet VM, Dreibach M, Bryson YJ: Double-blind study of central nervous system side-effects of amantadine. rimantadine, and chlorpheniramine. Antimicrob Agents Chemother 1982;21:1-4.
-
(1982)
Antimicrob Agents Chemother
, vol.21
, pp. 1-4
-
-
Millet, V.M.1
Dreibach, M.2
Bryson, Y.J.3
-
22
-
-
0018830555
-
A prospective double-blind study of side effects associated with the administration of amantadine for influenza A prophylaxis
-
Bryson YJ, Monahan C, Pollack M, Shields WD: A prospective double-blind study of side effects associated with the administration of amantadine for influenza A prophylaxis. J Infect Dis 1980:141:543-547.
-
(1980)
J Infect Dis
, vol.141
, pp. 543-547
-
-
Bryson, Y.J.1
Monahan, C.2
Pollack, M.3
Shields, W.D.4
-
23
-
-
0018396775
-
Prevention of Russian influenza by amantadine
-
Monto AS, Gunn RA, Bandyk MG, King CL: Prevention of Russian influenza by amantadine. JAMA 1979:241:1003-1007.
-
(1979)
JAMA
, vol.241
, pp. 1003-1007
-
-
Monto, A.S.1
Gunn, R.A.2
Bandyk, M.G.3
King, C.L.4
-
24
-
-
0025040474
-
Safety and prophylactic efficacy of low-dosc rimantadine in adults during an influenza A epidemic
-
Brady MT, Scars SD, Pacini DL, et al: Safety and prophylactic efficacy of low-dosc rimantadine in adults during an influenza A epidemic. Antimicrob Agents Chemother 1990: 34:1633-1636.
-
(1990)
Antimicrob Agents Chemother
, vol.34
, pp. 1633-1636
-
-
Brady, M.T.1
Scars, S.D.2
Pacini, D.L.3
-
25
-
-
0014429314
-
Studies on induced influenza in man
-
Dawkins AT Jr, Gallagher LR, Togo T, Hornick RB, Harris BA: Studies on induced influenza in man. JAMA 1968:34:1095-1099.
-
(1968)
JAMA
, vol.34
, pp. 1095-1099
-
-
Dawkins, A.T.1
Gallagher, L.R.2
Togo, T.3
Hornick, R.B.4
Harris, B.A.5
-
26
-
-
0025816458
-
Adverse reactions to amantadine prophylaxis of influenza in a retirement home
-
Stange KC, Little DW, Blatnik B: Adverse reactions to amantadine prophylaxis of influenza in a retirement home. J Am Gcriatr Soc 1991: 39:700-705.
-
(1991)
J am Gcriatr Soc
, vol.39
, pp. 700-705
-
-
Stange, K.C.1
Little, D.W.2
Blatnik, B.3
-
27
-
-
0025233673
-
Occurrence of adverse effects and high amantadine concentrations with influenza prophylaxis in the nursing home
-
Degclau J, Somani S, Cooper SL, Irvine PW: Occurrence of adverse effects and high amantadine concentrations with influenza prophylaxis in the nursing home. J Am Gcriatr Soc 1990:38:428-432.
-
(1990)
J am Gcriatr Soc
, vol.38
, pp. 428-432
-
-
Degclau, J.1
Somani, S.2
Cooper, S.L.3
Irvine, P.W.4
-
28
-
-
0023893594
-
The roles of vaccination and amantadine prophylaxis in controlling an outbreak of influenza A in a nursing home
-
Arden NH, Patriarca PA, Fasano B, et al: The roles of vaccination and amantadine prophylaxis in controlling an outbreak of influenza A in a nursing home. Arch Intern Med 1988;148:865-868.
-
(1988)
Arch Intern Med
, vol.148
, pp. 865-868
-
-
Arden, N.H.1
Patriarca, P.A.2
Fasano, B.3
-
29
-
-
0021842481
-
Prophylactic amantadine and plasma concentra-tion-eflect relationships in healthy adults
-
Aoki FY, Stiver HG, Sitar DS, Bou-dreault A, Ogilvie RI: Prophylactic amantadine and plasma concentra-tion-eflect relationships in healthy adults. Clin Pharmacol Ther 1985: 37:128-136.
-
(1985)
Clin Pharmacol Ther
, vol.37
, pp. 128-136
-
-
Aoki, F.Y.1
Stiver, H.G.2
Sitar, D.S.3
Bou-Dreault, A.4
Ogilvie, R.I.5
-
30
-
-
0021282343
-
Safety of prolonged administration of rimantadine hydrochloride in the prophylaxis of influenza A virus infections in nursing homes
-
Patriarca PA, Kater NA, Kendal AP, et al: Safety of prolonged administration of rimantadine hydrochloride in the prophylaxis of influenza A virus infections in nursing homes. Antimicrob Agents Chemother 1984:26:101-103.
-
(1984)
Antimicrob Agents Chemother
, vol.26
, pp. 101-103
-
-
Patriarca, P.A.1
Kater, N.A.2
Kendal, A.P.3
-
31
-
-
0022608508
-
Effectiveness of rimantadine prophylaxis of children within families
-
Clover RD, Crawford SA, Abell TD, Ramsey CN Jr, Glezen WP, Couch RB: Effectiveness of rimantadine prophylaxis of children within families. Am J Dis Child 1986; 140:706-709.
-
(1986)
Am J Dis Child
, vol.140
, pp. 706-709
-
-
Clover, R.D.1
Crawford, S.A.2
Abell, T.D.3
Ramsey, C.N.4
Glezen, W.P.5
Couch, R.B.6
-
32
-
-
0023933836
-
Rimantadine prophylaxis in children: A follow-up study
-
Crawford SA, Clover RD, Abell TD, Ramsey CN Jr, Glezen WP, Couch RB: Rimantadine prophylaxis in children: A follow-up study. Pediatr Infect Dis J 1988:7:379-383.
-
(1988)
Pediatr Infect Dis J
, vol.7
, pp. 379-383
-
-
Crawford, S.A.1
Clover, R.D.2
Abell, T.D.3
Ramsey, C.N.4
Glezen, W.P.5
Couch, R.B.6
-
33
-
-
0014082999
-
A field trial of amantadine prophylaxis in naturally-occurring acute respiratory illness
-
Finklea JF, Hennessy AV, Davenport FM: A field trial of amantadine prophylaxis in naturally-occurring acute respiratory illness. Am J Epidemiol 1967:85:403-412.
-
(1967)
Am J Epidemiol
, vol.85
, pp. 403-412
-
-
Finklea, J.F.1
Hennessy, A.V.2
Davenport, F.M.3
-
35
-
-
0014679633
-
Protective effect of 1-adamantanamine hydrochloride on influenza A2 infections in the family environment
-
Galbraith AE, Oxford JS, Schild GC, Watson GI: Protective effect of 1-adamantanamine hydrochloride on influenza A2 infections in the family environment. Lancet 1969:ii: 1026-1028.
-
(1969)
Lancet
, vol.2
, pp. 1026-1028
-
-
Galbraith, A.E.1
Oxford, J.S.2
Schild, G.C.3
Watson, G.I.4
-
36
-
-
0014658169
-
Study of 1-adamantanamine hydrochloride used prophylactically during the Hong Kong influenza epidemic in the family environment
-
Galbraith AW, Oxford JS, Schild GC, Watson GI: Study of 1-adamantanamine hydrochloride used prophylactically during the Hong Kong influenza epidemic in the family environment. Bull WHO 1969;41:677-682.
-
(1969)
Bull WHO
, vol.41
, pp. 677-682
-
-
Galbraith, A.W.1
Oxford, J.S.2
Schild, G.C.3
Watson, G.I.4
-
37
-
-
0024819536
-
Emergence and apparent transmission of rimantadine-resistant influenza A virus in families
-
Hayden FG, Belshe RB, Clover RD, Hay AJ, Oakes MG, Soo W: Emergence and apparent transmission of rimantadine-resistant influenza A virus in families. N Engl J Med 1989:321:1696-1702.
-
(1989)
N Engl J Med
, vol.321
, pp. 1696-1702
-
-
Hayden, F.G.1
Belshe, R.B.2
Clover, R.D.3
Hay, A.J.4
Oakes, M.G.5
Soo, W.6
-
38
-
-
0025678557
-
Acute upper respiratory tract viral illness and influenza immunisation in homes for the elderly
-
Nicholson KG, Baker DJ, Farquhar A, Hurd D. Kent J, Smith SH: Acute upper respiratory tract viral illness and influenza immunisation in homes for the elderly. Epidemiol Infect 1990;105:609-618.
-
(1990)
Epidemiol Infect
, vol.105
, pp. 609-618
-
-
Nicholson, K.G.1
Baker, D.J.2
Farquhar, A.3
Hurd, D.4
Kent, J.5
Smith, S.H.6
-
39
-
-
0021356597
-
Influenza A prophylaxis with amantadine in a boarding school
-
Payler DK, Purdham PA: Influenza A prophylaxis with amantadine in a boarding school. Lancet 1984;i:502-504.
-
(1984)
Lancet
, vol.1
, pp. 502-504
-
-
Payler, D.K.1
Purdham, P.A.2
-
40
-
-
84938041142
-
Amantadine prophylaxis during an institutional outbreak of type A (H INI) influenza
-
Atkinson WL, Arden NH, Patriarca PA, et al: Amantadine prophylaxis during an institutional outbreak of type A (H INI) influenza. Arch Intern Med 1986:146:1751-1756.
-
(1986)
Arch Intern Med
, vol.146
, pp. 1751-1756
-
-
Atkinson, W.L.1
Arden, N.H.2
Patriarca, P.A.3
-
41
-
-
0026002563
-
Emergence and possible transmission of amantadine resistant viruses during nursing home outbreaks of influenza A (H3N2)
-
Mast EE, Harmon MW, Graven-stcin S, et al: Emergence and possible transmission of amantadine resistant viruses during nursing home outbreaks of influenza A (H3N2). Am J Epidemiol 1991; 134:988-997.
-
(1991)
Am J Epidemiol
, vol.134
, pp. 988-997
-
-
Mast, E.E.1
Harmon, M.W.2
Graven-Stcin, S.3
-
42
-
-
0026529684
-
Amantadine-resistant influenza A in a nursing facility
-
Degelau J, Somani SK, Cooper SL, Guay DRP, Crossley KB: Amantadine-resistant influenza A in a nursing facility. Arch Intern Med 1992; 152:390-392.
-
(1992)
Arch Intern Med
, vol.152
, pp. 390-392
-
-
Degelau, J.1
Somani, S.K.2
Cooper, S.L.3
Guay, D.4
Crossley, K.B.5
-
43
-
-
0028934157
-
Amantadine-resistant virus prior to drug use
-
Houck P, Hemphill M, LaCroix S, Hirsh D, Cox N: Amantadine-resistant virus prior to drug use. Arch Intern Med 1995;155:533-537.
-
(1995)
Arch Intern Med
, vol.155
, pp. 533-537
-
-
Houck, P.1
Hemphill, M.2
Lacroix, S.3
Hirsh, D.4
Cox, N.5
-
44
-
-
0028781159
-
Prevention and control of influenza
-
II. Antiviral agents. Recommendations of the Advisory Committee on Immunization Practices (ACIP), RR-15
-
ACIP: Prevention and control of influenza. II. Antiviral agents. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 1994;43:RR-15.
-
(1994)
MMWR
, vol.43
-
-
-
45
-
-
0014515393
-
Treatment of influenza: The therapeutic efficacy of rimantadine HCI in a naturally occurring influenza A2 outbreak
-
Rabinovich S, Baldini JT, Bannister R: Treatment of influenza: The therapeutic efficacy of rimantadine HCI in a naturally occurring influenza A2 outbreak. Am J Med Sci 1969: 257:328-335.
-
(1969)
Am J Med Sci
, vol.257
, pp. 328-335
-
-
Rabinovich, S.1
Baldini, J.T.2
Bannister, R.3
-
46
-
-
0014671798
-
Therapeutic efficacy of amantadine HCI and rimantadine HCI in naturally occurring influenza A2 respiratory illness in man
-
Wingfield WL, Pollack D, Gruncrt RR: Therapeutic efficacy of amantadine HCI and rimantadine HCI in naturally occurring influenza A2 respiratory illness in man. N Engl J Med 1969:281:579-584.
-
(1969)
N Engl J Med
, vol.281
, pp. 579-584
-
-
Wingfield, W.L.1
Pollack, D.2
Gruncrt, R.R.3
-
47
-
-
0019516791
-
-
Van Voris LP, Betts RF, Hayden FG, Christmas WA, Douglas RG Jr: Successful treatment of naturally occurring influenza A/USSR/77 HINT JAMA 1981:245:1 128-1131.
-
(1981)
Successful Treatment of Naturally Occurring Influenza A/USSR/77 HINT JAMA
, vol.245
, Issue.1
, pp. 128-1131
-
-
Van Voris, L.P.1
Betts, R.F.2
Hayden, F.G.3
Christmas, W.A.4
Douglas, R.G.5
-
48
-
-
0022612664
-
Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults
-
Hayden FG, Monto A: Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults. Antimicrob Agents Chemothcr 1986;29:339-341.
-
(1986)
Antimicrob Agents Chemothcr
, vol.29
, pp. 339-341
-
-
Hayden, F.G.1
Monto, A.2
-
49
-
-
0023260541
-
Children with influenza A infection: Treatment with rimantadine
-
Hall CB, Dolin R, Gala CL, et al: Children with influenza A infection: Treatment with rimantadine. Pediatrics 1987:80:275-282.
-
(1987)
Pediatrics
, vol.80
, pp. 275-282
-
-
Hall, C.B.1
Dolin, R.2
Gala, C.L.3
-
50
-
-
0017164530
-
Amantadine effect on peripheral airways abnormalities in influenza: A study in 15 studentswith natural influenza A infection
-
Little JW, Hall WJ, Douglas RG, Hyde RW, Speers DM: Amantadine effect on peripheral airways abnormalities in influenza: A study in 15 studentswith natural influenza A infection. Ann Intern Med 1976:85: 177-182.
-
(1976)
Ann Intern Med
, vol.85
, pp. 177-182
-
-
Little, J.W.1
Hall, W.J.2
Douglas, R.G.3
Hyde, R.W.4
Speers, D.M.5
-
51
-
-
0018187984
-
Airways hyperreactivity and peripheral airway dysfunction in influenza A infection
-
Little JW, Hall WJ, Douglas RG, Mudholkar GS, Speers DM, Patel K: Airways hyperreactivity and peripheral airway dysfunction in influenza A infection. Am Rev Respir Dis 1978;118:295-303.
-
(1978)
Am Rev Respir Dis
, vol.118
, pp. 295-303
-
-
Little, J.W.1
Hall, W.J.2
Douglas, R.G.3
Mudholkar, G.S.4
Speers, D.M.5
Patel, K.6
-
52
-
-
0019840940
-
Occurrence of amantadine and rimantadine resistant influenza A virus strains during the 1980 epidemic
-
Heider H, Adamczyk B, Prcsber C, Schroeder C, Fcldblum R, Indulen MK: Occurrence of amantadine and rimantadine resistant influenza A virus strains during the 1980 epidemic. Acta Virol (Praha) 1981:25: 395-400.
-
(1981)
Acta Virol (Praha)
, vol.25
, pp. 395-400
-
-
Heider, H.1
Adamczyk, B.2
Prcsber, C.3
Schroeder, C.4
Fcldblum, R.5
Indulen, M.K.6
-
53
-
-
0024328816
-
The importance of virus drug resistance in the treatment of influenza with rimantadine
-
Kubar OI, Brjantscrva LE, Nikitina LE, Zlydnikov DM: The importance of virus drug resistance in the treatment of influenza with rimantadine. Antiviral Res 1989;11:313-316.
-
(1989)
Antiviral Res
, vol.11
, pp. 313-316
-
-
Kubar, O.I.1
Brjantscrva, L.E.2
Nikitina, L.E.3
Zlydnikov, D.M.4
-
54
-
-
0025815157
-
Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine
-
Hayden FG, Sperbcr SJ, Belshe RB, Clover RD, Hay AJ, Pykc S: Recovery of drug-resistant influenza A virus during therapeutic use of rimantadine. Antimicrob Agents Che-mother 1991:35:1741-1747.
-
(1991)
Antimicrob Agents Che-Mother
, vol.35
, pp. 1741-1747
-
-
Hayden, F.G.1
Sperbcr, S.J.2
Belshe, R.B.3
Clover, R.D.4
Hay, A.J.5
Pykc, S.6
-
55
-
-
0026603612
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Emergence and transmission of influenza A viruses resistant to amantadine and rimantadine
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Hayden FG, Hay AJ: Emergence and transmission of influenza A viruses resistant to amantadine and rimantadine. Curr Top Microbiol Immunol 1992;176:119-130.
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(1992)
Curr Top Microbiol Immunol
, vol.176
, pp. 119-130
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Hayden, F.G.1
Hay, A.J.2
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