Acute, short-term, and subchronic oral toxicity of 1,1,1-trichloroethane in rats

Toxicological Sciences

Volumn 60, Issue 2, 2001, Pages 363-372

  Bruckner, James V ^a   Kyle, Glenna M ^b   Luthra, Raja ^c   Acosta, Daniel ^d   Mehta, Sanjay M ^a   Sethuraman, Sankar ^e   Muralidhara, Srinivasa ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d UNIVERSITY OF CINCINNATI   (United States)

^e AUGUSTA STATE UNIVERSITY   (United States)

Author keywords

1,1,1 trichloroethane; CYP2B1 2; CYP2E1; Cytochrome P450 induction; Liver toxicity; Methylchloroform; Noncancer risk assessment

Indexed keywords

1,1,1 TRICHLOROETHANE; ALANINE AMINOTRANSFERASE; CYTOCHROME P450 2E1; IDITOL DEHYDROGENASE; ORNITHINE CARBAMOYLTRANSFERASE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CENTRAL NERVOUS SYSTEM DEPRESSION; CHRONIC TOXICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INDUCTION; FATALITY; FEEDING; HISTOPATHOLOGY; LIVER INJURY; LIVER TOXICITY; MALE; NONHUMAN; ORGAN WEIGHT; RAT; RAT STRAIN;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; L-IDITOL 2-DEHYDROGENASE; LIVER; LONGEVITY; MALE; MICROSOMES, LIVER; ORGAN SIZE; ORNITHINE CARBAMOYLTRANSFERASE; RATS; RATS, SPRAGUE-DAWLEY; SOLVENTS; TOXICITY TESTS; TRICHLOROETHANES; WEIGHT GAIN;

ANIMALIA;

EID: 0035072901     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/60.2.363     Document Type: Article

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