Evaluation of rat hepatic 2E1 activity in function of age, sex and inducers: Choice of an experimental model capable of testing the hepatotoxicity of low molecular weight compounds

Toxicology Letters

Volumn 106, Issue 2-3, 1999, Pages 171-180

  Morel, G ^a   Cossec, B ^a   Lambert, A M ^a   Binet, S ^a  

^a INSTITUT NATIONAL DE RECHERCHE ET DE SÉCURITÉ   (France)

Author keywords

Activity; Cytochrome P450 2E1; Inducers; Liver; Rat

Indexed keywords

4 NITROPHENOL; ACETONE; ALCOHOL; BETA NAPHTHOFLAVONE; CHLORZOXAZONE; CYTOCHROME P450 ISOENZYME; DIMETHYLNITROSAMINE DEMETHYLASE; ENZYME INDUCING AGENT; INDUSTRIAL CHEMICAL; OXYGENASE; PHENOBARBITAL; PYRIDINE;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; EXPERIMENTAL MODEL; FEMALE; GENDER; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER MICROSOME METABOLISM; LIVER TOXICITY; MALE; MOLECULAR WEIGHT; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; XENOBIOTIC METABOLISM;

AGE FACTORS; ANIMALS; CHLORZOXAZONE; CYTOCHROME P-450 CYP2E1; ENZYME INDUCTION; FEMALE; LIVER; MALE; MOLECULAR WEIGHT; NITROPHENOLS; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS;

ANIMALIA;

EID: 0033065962     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(99)00058-2     Document Type: Article

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