Cerebral gyral dysplasias: Molecular genetics and cell biology

Current Opinion in Neurology

Volumn 14, Issue 2, 2001, Pages 157-162

  Clark, Gary D ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Cain Foundation Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLECORTIN;

AGYRIA; BRAIN DEVELOPMENT; DYSPLASIA; GENE DELETION; HETEROTOPIA; HUMAN; MOLECULAR GENETICS; PHENOTYPE; POINT MUTATION; PROTEIN PROTEIN INTERACTION; REVIEW;

1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; ANIMALS; CELL ADHESION MOLECULES, NEURONAL; CELL MOVEMENT; CEREBRAL CORTEX; EXTRACELLULAR MATRIX PROTEINS; HUMANS; MICE; MICE, NEUROLOGIC MUTANTS; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; NERVE TISSUE PROTEINS; NERVOUS SYSTEM MALFORMATIONS; NEUROPEPTIDES; SERINE ENDOPEPTIDASES;

EID: 0035072821     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019052-200104000-00004     Document Type: Review

References (50)

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2. A protein related to extracellular matrix proteins deleted in the mouse reeler
3. The reeler gene encodes a protein with an EGRF-like motif expressed by pioneer neurons
4. The reeler gene-associated antigen on Cajal-Retziu neurons is a crucial molecule for laminar organization of cortical neurons
5. Aberrant splicing of a mouse disabled homolog, mdab1, in the scrambler mouse
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8. Reelin is a ligand for lipoprotein receptors
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11. Proteins of the CNR family are multiple receptors for Reelin
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14. Isolation of a Miller-Dieker lissencephaly gene containing G protein β-subunit-like repeats
15. Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase
16. Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer
17. PAF analogues capable of inhibiting PAF acetylhydrolase activity suppress migration of isolated rat cerebellar granule cells
18. Platelet-activating factor receptor stimulation disrupts neuronal migration in vitro
19. NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration
20. Isolation of a new set of Aspergillus nidulans mutants defective in nuclear migration
21. NudF, a nuclear migration gene in Aspergillus nidulans, is similar to human LIS-1 gene required for neuronal migration
22. The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC
23. The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein
24. LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome
25. Direct association of LIS1, the lissencephaly gene product, with a mammalian homologue of a fungal nuclear distribution protein, rNUDE
26. Nudel is a novel Cdk5 substrate that associates with Lis1 and cytoplasmic dynein
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28. NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins
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30. The drosophila lissencephalyl (DLis1) gene is required for nuclear migration
31. Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transport
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33. A rough guide to a smooth brain
34. Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality
35. Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein
36. A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome
37. Characterization of mutations in the gene doublecortin in patients with double cortex syndrome
38. Classical lissencephaly and double cortex (subcortical band heterotopia): LIS1 and doublecortin
39. Somatic and germline mosaic mutations in the doublecortin gene are associated with variable phenotypes
40. Genetic and neuroradiological heterogeneity of double cortex syndrome
41. Lissencephaly and subcortical band heterotopia: Molecular basis and diagnosis
42. KIAA0369, doublecortin-like kinase, is expressed during brain development
43. DCAMKL1 encodes a protein kinase with homology to Doublecortin that regulates microtubule polymerization
44. DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX)
45. Doublecortin, a stabilizer of microtubules
46. Doublecortin is a microtubuleassociated protein and is expressed widely by migrating neurons
47. Doublecortin mutations cluster in evolutionarily conserved functional domains
48. Patient mutation in Doublecortin define a repeated tubulin-binding domain
49. Colocalization of doublecortin with the microtubules: An ex vivo colocalization study of mutant doublecortin
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