Early detection of pancreatic cancer in patients with chronic pancreatitis: Diagnostic utility of a K-ras point mutation in the pancreatic juice

American Journal of Gastroenterology

Volumn 96, Issue 3, 2001, Pages 700-704

  Queneau, Pierre Edouard ^a   Adessi, Gérard Louis ^b   Thibault, Pascal ^d   Cléau, Denis ^e   Heyd, Bruno ^c   Mantion, Georges ^c   Carayon, Pierre ^a  

^a Services de Gastroentérologie   (Switzerland)

^b Services d Oncologie et d Endocrinologie Moléculaires   (Switzerland)

^c Dept of Physiology   (Switzerland)

^d CHG Lons le Saulnier   (France)

^e CHG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; K RAS PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ALCOHOLIC PANCREATITIS; ARTICLE; AUTOIMMUNE DISEASE; CANCER DIAGNOSIS; CANCER GROWTH; CANCER INVASION; CANCER RISK; CANCER STAGING; CHRONIC PANCREATITIS; CLINICAL ARTICLE; CLINICAL PRACTICE; CONTROLLED STUDY; EARLY DIAGNOSIS; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; FEMALE; GENE MUTATION; HUMAN; MALE; ONCOGENE K RAS; PANCREAS CARCINOMA; PANCREAS DIVISUM; PANCREAS JUICE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RISK FACTOR; SEX DIFFERENCE;

ADENOCARCINOMA; ADULT; AGED; CHRONIC DISEASE; FEMALE; GENES, RAS; HUMANS; MALE; MIDDLE AGED; PANCREAS; PANCREATIC JUICE; PANCREATIC NEOPLASMS; PANCREATITIS; POINT MUTATION; PROSPECTIVE STUDIES; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0035072352     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9270(00)02401-1     Document Type: Article

References (38)

1. Pancreatic carcinoma
2. Pancreatic carcinoma in perspective: A continuing challenge
3. Epidemiology and risk factors in pancreatic cancer
4. The risk of pancreatic cancer following pancreatitis: An association due to confounding?
5. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras gene
6. Clinical applications of ras gene mutation for diagnosis of pancreatic adenocarcinoma
7. K-ras oncogene activation in preinvasive pancreatic cancer
8. ERCP meets c-K-ras: Towards an improved diagnosis of pancreatic cancer
9. Long-term follow-up of patients with chronic pancreatitis, and K-ras gene mutation detected in pancreatic juice
10. Genetic alterations in chronic pancreatitis: Evidence of early occurrence of p53 but not K-ras mutations
11. K-ras mutations at codon 12 are rare events in chronic pancreatitis
12. K-ras mutations in stools, and tissue samples from patients with malignant, and nonmalignant pancreatic diseases
13. Identification of K-ras mutations in pancreatic juice in the early diagnosis of pancreatic cancer
14. A case of small pancreatic cancer diagnosed by serial follow-up studies promptly by a positive K-ras point mutation in pure pancreatic juice
15. Classification of pancreatitis
16. Revised classification of chronic pancreatitis. Report of the Second International Symposium on the Classification of Pancreatitis, Marseille, France, March 28-30, 1984
17. Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique
18. Rapid and sensitive nonradioactive detection of mutant K-ras genes via "enriched" PCR amplification
19. Quantitative analysis of ras gene mutation in pancreatic juice for diagnosis of pancreatic adenocarcinoma
20. Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease
21. Frequent c-K-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation
22. A prospective study of K-ras mutations in the plasma of pancreatic cancer patients
23. Pancreatitis and the risk of pancreatic cancer
24. Endoscopic ultrasonographic diagnosis of pancreatic cancer complicating chronic pancreatitis
25. The clinical utility of endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of pancreatic carcinoma
26. 18Fluorodeoxyglucose-positron emission tomography in the management of patients with suspected pancreatic cancer
27. Detection of c-Ki-ras gene codon 12 mutations from pancreatic duct brushings in the diagnosis of pancreatic tumours
28. Diagnostic utility of K-ras mutations in fine-needle aspirates of pancreatic masses
29. Molecular advances in pancreatic cancer
30. Advances from genetic clues in pancreatic cancer
31. Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic and carcinomatous lesions of the pancreas: Evidence for multistep carcinogenesis
32. The K-ras mutation pattern in pancreatic ductal adenocarcinoma is usually identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium
33. Loss of expression of DPC4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression
34. Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer
35. Ki-ras, and p53 gene mutations in pancreatic ductal carcinoma: A relationship with tumor phenotype and survival
36. P16, and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma
37. Detection of K-ras mutations in the stools of patients with pancreatic adenocarcinoma, and pancreatic ductal hyperplasia
38. Detection of K-ras gene mutations in plasma DNA of patients with adenocarcinoma: Correlation with clinicopathological features