Promoting effects of xylazine on development of thyroid tumors in rats initiated with N-bis(2-hydroxypropyl)nitrosamine and the mechanism of action

Carcinogenesis

Volumn 22, Issue 4, 2001, Pages 613-618

  Yasuhara, Kazuo ^a   Koujitani, Takatoshi ^a   Takegawa, Kiyoshi ^b   Nasu, Masahiro ^c   Onodera, Hiroshi ^a   Takagi, Hisayoshi ^a   Hirose, Masao ^a   Mitsumori, Kunitoshi ^a,d  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b Pharmaceutical Research Division   (Japan)

^c Panapharm Laboratories Co Ltd   (Japan)

^d TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIS(2 HYDROXYPROPYL)NITROSAMINE; IODIDE; LIOTHYRONINE; SEDATIVE AGENT; THYROTROPIN; THYROXINE; XYLAZINE;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INCIDENCE; CARCINOGENESIS; CELL HYPERPLASIA; CONTROLLED STUDY; DIET; DRUG MECHANISM; FEEDBACK SYSTEM; FOOD INDUSTRY; HISTOPATHOLOGY; HYPOPHYSIS THYROID SYSTEM; MALE; MULTIPLE CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN BOUND IODINE; RAT; THYROID ADENOMA; THYROID CANCER; THYROID CARCINOMA; THYROID FOLLICLE CELL; THYROID HORMONE BLOOD LEVEL; THYROID WEIGHT; THYROTROPIN BLOOD LEVEL; TIME; TUMOR PROMOTION;

EID: 0035072199     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.4.613     Document Type: Article

References (30)

1. Xylazine- a review of its pharmacology and use in veterinary medicine
2. Use of alpha-2-adrenergic receptor antagonists
3. Simultaneous determination of xylazine and its major metabolite, 2,6-dimethylaniline, in bovine and swine kidney by liquid chromatography
4. Toxicological evaluation of certain veterinary drug residues in food
5. Evaluation of certain veterinary drug residues in food
6. Toxicology and carcinogenesis studies of 2,6-xylidine (2,6-dimethylaniline) in Charles River CD rats (feed studies)
7. L5178Y mouse lymphoma cell mutagenesis assay of coded chemicals incorporating analyses of the colony size distributions
8. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals
9. Screening of tobacco smoke constituents for mutagenicity using the Ames test
10. Bacterial mutagenicity and mammalian cell DNA damage by several substituted anilines
11. The regulatory status of xylazine for use in food-producing animals in the United States
12. Tumor promoting activity of 2,6-dimethylaniline in a two-stage nasal carcinogenecity model in rats initiated with N-bis(2-hydroxypropyl)nitosamine
13. Absence of tumor promoting activity of xylazine in two-stage nasal carcinogenesis model in N-bis(2-hydroxypropyl)nitrosamine-treated rats
14. Toxicity and blood concentrations of xylazine or its metabolite, 2,6-dimethylaniline, in rats after the single or repeated oral administration
15. Thyroid and parathyroid toxicology
16. Thyroid gland neoplasia: Non-genotoxic mechanisms
17. Review: Thyroid follicular cell carcinogenesis
18. Protein measurement with the folin phenol reagent
19. Carcinogenic effects of diisopropanolnitrosamine in Sprague-Dawley rats
20. Carcinogenicity of N-nitrosobis(2-hydroxypropyl)amine and N-nitrosobis(2-oxopropyl)amine in MRC rats
21. Relationships between serum thyroid stimulating hormone levels and development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine
22. Frequent mutations of Ki-ras codon 12 in N-bis(2-hydroxypropyl)-nitrosamine-initiated thyroid, kidney and lung tumors in Wistar rats
23. 4,4'-Diaminodiphenylmethane: Promoting effect on development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine
24. Effect of propylthiouracil on the thyroid tumorigenesis induced by N-bis(2-hydroxypropyl)nitrosamine in rats
25. Time course observation of thyroid proliferative lesions and serum TSH levels in rats treated with thiourea after DHPN initiation
26. Promoting effects of kojic acid due to serum TSH elevation resulting from reduced serum thyroid hormone levels on development of thyroid proliferative lesions in rats initiated with N-bis(2-hydroxypropyl)nitrosamine in rats
27. Characterization of metabolites of xylazine produced in vivo and in vitro by LC/MS/ MS and by GC/MS
28. Effect of simultaneous treatment with large amounts of vitamine A and thiourea on thyroid iodine uptake and organification
29. Promoting effect of 2,4-diaminoanisole sulfate on rat thyroid carcinogenesis
30. The effect of phenobarbital on the metabolism and excretion of thyroxine in rats