Inhibitory effect of olopatadine hydrochloride (KW-4679), a novel antiallergic drug, on peptide leukotriene release from human eosinophils

Allergology International

Volumn 50, Issue 1, 2001, Pages 113-116

  Miyake, K ^a   Ohmori, K ^a   Ishii, A ^a   Karasawa, A ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Antiallergic drug; Human eosinophils; Leukotriene; Olopatadine

Indexed keywords

ANTIALLERGIC AGENT; CALCIMYCIN; CALCIUM IONOPHORE; KETOTIFEN; LEUKOTRIENE; OLOPATADINE; THROMBOXANE B2;

ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; EOSINOPHIL; HUMAN; HUMAN CELL; IC 50; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN SECRETION;

EID: 0035072066     PISSN: 13238930     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1592.2001.00207.x     Document Type: Article

References (17)

1. Bosophils and eosinophils in allergic rhinitis
2. Free eosinophil granules in urticaria: A correlation with the duration of wheals
3. The eosinophilic leukocyte: Structure and function
4. Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation
5. Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivatives
6. 1 receptor
7. KW-4679, an anti-allergic drug, inhibits the production of inflammatory lipids in human polymorphonuclear leukocytes and guinea pig eosinophils
8. Oxatomide inhibits the release of chemical mediators from human lung tissue and granulocytes
9. Inhibitory effect of ONO-1078, a novel leukotriene receptor antagonist, on human peripheral blood eosinophils
10. Biochemical and functional differences between eosinophils from animal species and man
11. 2,3-Dihydro-5-benzofuranols as antioxidant-based inhibitors of leukotriene biosynthesis
12. Effects of ketotifen on chemiluminescence of human neutrophils
13. The effect of KW-4679, an antiallergic drug, on experimental allergic rhinitis in guinea pigs: Effects on nasal blockage
14. The clinical evaluation of KW-4679 (olopatadine hydrochloride) in the treatment of perennial allergic rhinitis: A double-blind comparative study using oxatomide as the control
15. Involvement of cysteinyl leukotrienes in biphasic increase of nasol airway resistance of antigen-induced rhinitis in guinea pigs
16. Pharmacologic prophylaxis of allergic rhinitis: Relative efficacy of hydroxyzine and chlorpheniramine
17. Clinical investigation of ketotifen in perennial allergic rhinitis: A double-blind comparative study of ketotifen and clemastine fumarate