Unique binding pocket for KW-4679 in the histamine H1 receptor

European Journal of Pharmacology

Volumn 345, Issue 1, 1998, Pages 111-117

  Nonaka, Hiromi ^a   Otaki, Shizuo ^a   Ohshima, Etsuo ^a   Kono, Motomichi ^a   Kase, Hiroshi ^a   Ohta, Kazumi ^b   Fukui, Hiroyuki ^c   Ichimura, Michio ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

^c OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Binding assay; Histamine H1 receptor; KW 4679 ((Z) 11 3 (dimethylamino)propylidene 6,11 dihydrodibenz b,e oxepin 2 acetic acid; Site directed mutagenesis

Indexed keywords

HISTAMINE H1 RECEPTOR; OLOPATADINE;

ANIMAL CELL; ARTICLE; BINDING SITE; DRUG RECEPTOR BINDING; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS;

ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; DIBENZOXEPINS; HISTAMINE AGONISTS; HISTAMINE H1 ANTAGONISTS; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; RADIOLIGAND ASSAY; RECEPTORS, HISTAMINE H1;

EID: 0032510552     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01620-8     Document Type: Article

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