Pharmacokinetic study of esomeprazole in the elderly

Clinical Pharmacokinetics

Volumn 40, Issue 2, 2001, Pages 145-150

  Hasselgren, G ^a   Hassan Alin, M ^a   Andersson, T ^b   Claar Nilsson, C ^a   Rohss K ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG METABOLITE; ESOMEPRAZOLE;

ABDOMINAL PAIN; AGED; AGING; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FLATULENCE; GASTROESOPHAGEAL REFLUX; HEADACHE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL;

EID: 0035069788     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-200140020-00006     Document Type: Article

References (19)

1. Proton pump inhibitors: Pharmacology and rationale for use in gastrointestinal disorders
2. Age and cytochrome P450-linked drug metabolism in humans: An analysis of 226 subjects with equal histopathologic conditions
3. Pharmacokinetics, metabolism and interactions of acid pump inhibitors. Focus on omeprazole, lansoprazole and pantoprazole
4. Pantoprazole in the elderly: No dose-adjustment
5. Single and multiple dose pharmacokinetics of lansoprazole in elderly subjects
6. Pharmacokinetic study of omeprazole in elderly healthy volunteers
7. Esomeprazole provides improved acid control versus omeprazole in patients with symptoms of gastro-esophageal reflux disease
8. Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes
9. Determination of omeprazole and metabolites in plasma and urine by liquid chromatography
10. Age-related differences in the pharmacokinetics and pharmacodynamics of lansoprazole
11. Rabeprazole: Pharmacokinetics and safety in the elderly
12. Clinical pharmacokinetics of lansoprazole
13. Lansoprazole pharmacokinetics differ in patients with esophagitis compared to healthy volunteers
14. Oral bioavailability of omeprazole before and after chronic therapy in patients with duodenal ulcer
15. Pharmacokinetics of esomeprazole after oral and intravenous administration of single and repeated doses to healthy subjects
16. Impairment of lidocaine clearance in elderly male subjects
17. Lignocaine kinetics in cardiac patients and aged subjects
18. Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism
19. Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism