Design and evaluation of a new mucoadhesive bi-layered tablet containing nimesulide for buccal administration

S.T.P. Pharma Sciences

Volumn 11, Issue 2, 2001, Pages 151-156

  Ceschel, G C ^a   Maffei, P ^a   Lombardi Borgia, S ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Bi layered tablet; Buccal absorption; Buccal mucoadhesive tablet; In vitro release; Nimesulide; Permeation test

Indexed keywords

CARBOMER; CARBOXYMETHYLCELLULOSE; HYDROXYPROPYLCELLULOSE; LACTOSE; MAGNESIUM STEARATE; NIMESULIDE; POVIDONE; TALC;

ADHESION; ANIMAL TISSUE; ARTICLE; CHEEK MUCOSA; DRUG ABSORPTION; DRUG DESIGN; DRUG PENETRATION; DRUG SCREENING; HUMAN; HUMAN EXPERIMENT; NONHUMAN; NORMAL HUMAN; TABLET FORMULATION; TABLET PROPERTY;

EID: 0035069282     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Nimesulide, a new non-steroideal anti-inflammatory agent
2. Nimesulide: Some pharmaceutical and pharmacological aspects, an update
3. Inhibition of consecutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and COX-2 inhibitors
4. Anti-inflammatory activity of 4-nitro-2- phenoxymethansulfonanilide (R 805)
5. An assessment of nimesulide by comparison with naproxen in the treatment of pain following oral surgery (in Portuguese)
6. A controlled clinical study of the efficacy and tolerability of nimesulide versus naproxen in maxillofacial surgery
7. Analgesic efficacy and pharmacokinetics of topical nimesulide gel in healthy human volunteers: Double-blind comparison with piroxicam, diclofenac and placebo
8. Anti-inflammatory activity of topical nimesulide gel in various experimental models
9. Comparative analgesic efficacy of nimesulide and diclofenac gels after topical application on the skin
10. Organic nitrates, relationship between biotrasformation and rational angina pectoris therapy
11. Effect of isosorbide dinitrate tape (TY-0081) on congestive heart failure: Results of multiclinical study
12. A new transmucosal therapeutic system for the systemic delivery of isosorbide dinitrate: In vitro and in vivo evluation in Beagle dogs
13. Formulation of biphasic release tablets containing slightly soluble drugs
14. Formulation development and in vivo evalution of a novel biohadesive lozenge containing a sinergistic combination of antiffungal agents
15. Evaluation on the suitability of differential scanning calorimetry in the preformulation stability sceening
16. In vitro permeation through porcine buccal mucosa of Salvia Desoleana Atzei & Picci essential oil from topical formulations
17. Percutaneous absorption. On the relevance on in vitro data
18. In vitro skin permeation techniques
19. In vitro methods for measuring permeability of the oral mucosa
20. A simple equation for description of solute release. II. Fickian and anomalous release from swellable devices
21. Bioadhesive hydrogel
22. Experimental methods for determination of bioadhesive bond strength of polymers with mucus
23. Bioadhesive analysis of controlled-release systems. I. Fracture and interpenetration analysis in poly(acrylic acid)-containing systems
24. In vitro correlation of the bioadhesive properties of a buccal bioadhesive miconazole slow-release tablet