Comparison of cardiovascular effects of a new calcium channel blocker AH-1058 with those of verapamil assessed in blood-perfused canine heart preparations

Journal of Cardiovascular Pharmacology

Volumn 35, Issue 5, 2000, Pages 741-748

  Takahara, Akira ^a   Sugiyama, Atsushi ^a,b   Dohmoto, Hideki ^a   Yoshimoto, Ryota ^a   Hashimoto, Keitaro ^b  

^a AJINOMOTO CO INC   (Japan)

^b UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

AH 1058; Calcium channel blocker; Chronotropic; Coronary vasodilator; Dromotropic; Inotropic

Indexed keywords

4 (5H DIBENZO[A,D]CYCLOHEPT 5 YLIDENE) 1 [3 (3 METHOXY 2 NITROPHENYL) 2 PROPENYL]PIPERIDINE; CALCIUM CHANNEL BLOCKING AGENT; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR CONDUCTION; CARDIOVASCULAR DISEASE; CHRONOTROPISM; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DILATATION; DOG; HEART AUTOMATICITY; HEART PAPILLARY MUSCLE; INOTROPISM; ISOLATED HEART; NONHUMAN; PRIORITY JOURNAL; SINUS NODE;

ANIMALS; ATRIOVENTRICULAR NODE; BICYCLO COMPOUNDS; CALCIUM CHANNEL BLOCKERS; DOGS; ELECTROCARDIOGRAPHY; FEMALE; HEART; HEMODYNAMIC PROCESSES; MALE; PAPILLARY MUSCLES; PIPERIDINES; SINOATRIAL NODE; VERAPAMIL;

EID: 0034056473     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200005000-00010     Document Type: Article

References (4)

1. Taira N. Differences in cardiovascular profile among calcium antagonists. Am J Cardiol 1987;59:24-9B.
2. Kawai C, Konishi T, Matsuyama E, Okazaki H. Comparative effects of three calcium antagonists, diltiazem, verapamil and nifedipine, on the sino-atrial and atrioventricular nodes: experimental and clinical studies. Circulation 1981;63:1035-42.
3. Takahara A, Uneyama H, Sasaki N, et al. Effects of AH-1058, a new antiarrhythmic drug, on experimental arrhythmias and cardiac membrane currents. J Cardiovasc Pharmacol 1999;33:625-32.
4. Tanaka H, Ichikawa T, Matsui S, et al. Calcium channel antagonistic effects of AH-1058, a novel antiarrhythmic drug, on guinea-pig myocardium. Res Commun Mol Pathol Pharmacol 1999;104:13-21.