Oxidative damage and direct adducts in calf thymus DNA induced by the pentachlorophenol metabolities, tetrachlorohydroquinone and tetrachloro-1, 4-benzoquinone

Carcinogenesis

Volumn 22, Issue 4, 2001, Pages 627-634

  Lin, Po Hsiung ^a,b   Nakamura, Jun ^a   Yamaguchi, Shuji ^a   Upton, Patricia B ^a   La, David K ^a   Swenberg, James A ^a  

^a IL   (United States)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CATALASE; CHLORANIL; CLASTOGEN; COPPER; DNA; DNA BASE; HYDROGEN PEROXIDE; HYDROQUINONE DERIVATIVE; NUCLEOTIDE; PENTACHLOROPHENOL; PHOSPHORUS 32; PURINE; PYRIMIDINE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SINGLE STRANDED DNA; TETRACHLOROHYDROQUINONE;

ANIMAL TISSUE; APURINIC SITE; APYRIMIDINIC SITE; ARTICLE; ASSAY; CARCINOGENICITY; CATTLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION FUNCTION; DNA ADDUCT; DNA CLEAVAGE; DNA DAMAGE; DNA MODIFICATION; DNA STRAND BREAKAGE; ENZYME INHIBITION; GENOME; METABOLITE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; THERMAL ANALYSIS; THYMUS;

EID: 0035067242     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.4.627     Document Type: Article

References (35)

1. Toxicology and carcinogenesis studies of two grades of pentachlorophenol in B6C3F1 mice
2. Toxicology and carcinogenesis studies of pentachlorophenol in rats
3. Oxidative DNA lesions in V79 cells mediated by pentachlorophenol metabolites
4. Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals
5. Induction of micronuclei in V79 Chinese hamster cells by tetrachlorohydroquinone, a metabolite of pentachlorophenol
6. Role of active oxygen species in DNA damage by pentachlorophenol metabolites
7. The pentachlorophenol metabolite tetrachloro-p-hydroquinone induces the formation of 8-hydroxy-2-deoxyguanosine in liver DNA of male B6C3F1 mice
8. Pentachlorophenol-induced oxidative DNA damage in mouse liver and protective effect of antioxidants
9. Oxidative DNA damage and cell proliferation in the livers of B6C3F1 mice exposed to pentachlorophenol in their diet
10. Pentachlorophenol
11. Chromosome changes in lymphocytes after occupational exposure to pentachlorophenol (PCP)
12. The microsomal metabolism of hexachlorobenzene. Origin of the covalent binding to protein
13. Induction of glutathione depletion, p53 protein accumulation and cellular transformation by tetrachlorohydroquinone, a toxic metabolite of pentachlorophenol
14. Reactions of oxyl radicals with DNA
15. DNA strand breaking by the hydroxyl radical is governed by the accessible surface areas of the hydrogen atoms of the DNA backbone
16. 5′-Nicked apurinic/apyrimidinic sites are resistant to β-elimination by β-polymerase and are persistent in human cultured cells after oxidative stress
17. The role of hydroxyl radicals in tetrachlorohydroquinone induced DNA strand break formation in PM2 DNA and human fibroblasts
18. The effect of pentachlorophenol and its metabolite tetrachlorohydroquinone on cell growth and the induction of DNA damage in Chinese hamster ovary cells
19. Analysis of DNA adducts in rats chronically exposed to pentachlorophenol
20. Oxidation of eugenol to form DNA adducts and 8-hydroxy-2′-deoxyguanosine: Role of quinone methide derivative in DNA adduct formation
21. Molecular origin of cancer: Catechol estrogen-3,4-quinones as endogenous tumor initiators
22. Synthesis and characterization of polycyclic aromatic hydrocarbon o-quinone depurinating N7-guanine adducts
23. Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues
24. Highly sensitive apurinic/apyrimidinic site assay can detect spontaneous and chemically induced depurination under physiological conditions
25. 32P-postlabeling test for structurally diverse DNA adducts
26. 32P-postlabeling analysis of aromatic carcinogen: DNA adducts
27. Normal oxidative damage to mitochondrial and nuclear DNA is extensive
28. Quantitation of radiation-, chemical-, or enzyme-induced single strand breaks in nonradioactive DNA by alkaline gel electrophoresis: Application to pyrimidine dimers
29. The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro
30. Mechanism of oxidative DNA damage induced by a heterocyclic amine, 2-amino-3,8-dimethylimidazo(4,5f)quinoxaline
31. Oxidation of unsaturated compounds
32. Genetic alterations in the 61st codon of the H-ras oncogene isolated from archival sections of hepatic hyperplasias, adenomas and carcinomas in control groups of B6C3F1 mouse bioassay studies conducted from 1979 to 1986
33. Rat mesothelial and tracheal epithelial cells show equal DNA sensitivity to hydrogen peroxide-induced oxidant injury
34. Altered gene expression in spontaneous hepatocellular carcinomas from male B6C3F1 mice
35. DNA breakage in asbestos-treated normal and transformed (TSV40) rat pleural mesothelial cells