Efficiency of imidazolium and quinuclidinium derivatives combined with HI-6 or diazepam in soman and tabun poisoning

Acta Pharmaceutica

Volumn 51, Issue 1, 2001, Pages 1-9

  Radic B ^a   Lucic A ^a   Peraica, M ^a   Domijan, A M ^a   Bradamante, V ^a  

^a INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH   (Croatia)

Author keywords

Acethylcholinesterase; Antidotes; Imidazolium; Oximes; Quinuclidinium; Soman; Tabun

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; ANTIDOTE; ATROPINE; DIAZEPAM; IMIDAZOLE DERIVATIVE; OXIME; QUINUCLIDINE DERIVATIVE; SOMAN; TABUN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVULSION; CYANOSIS; DOSE TIME EFFECT RELATION; DRUG EFFICACY; DYSPNEA; FASCICULATION; INTOXICATION; MALE; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RESPIRATORY TRACT DISEASE; SCORING SYSTEM; SYNAPSE; TREMOR;

EID: 0035066495     PISSN: 13300075     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. 3-Hydroxyquinuclidinium derivatives: Synthesis of compounds and inhibition of acetylcholinesterase
2. Quinuclidinium-imidazolium compounds: Synthesis, mode of interaction with acetylcholinesterase and effect upon soman intoxicated mice
3. Synthesis, acute toxicity and protective action of some new oximes in experimental soman poisoning. Imidazole derivatives. VI
4. Use of moving averages and interpolation to estimate median-effective dose
5. 50) and instructions in their use
6. Structure-activity relationships of new antidotes in therapy of soman poisoning
7. Antidotal efficacy of the bisquaternary oximes: AB-8, AB-13, toxogonin, HI-6 and Hlo-7 against tabun and soman poisoning
8. 3-Carbamyl-N-allylquinuclidinium bromide. Effects on cholinergic activity and protection against soman
9. Pharmacological effects of oxime: How relevant are they?
10. Effects in the Brain of HI-6 Treatment
11. Pharmacokinetics and effects of HI-6 in blood and brain of soman-intoxicated rats: A microdialysis study