14-Week toxicity and cell proliferation of methyleugenol administered by gavage to F344 rats and B6C3F1 mice

Food and Chemical Toxicology

Volumn 39, Issue 4, 2001, Pages 303-316

  Abdo, K M ^a   Cunningham, M L ^a   Snell, M L ^a   Herbert, R A ^a   Travlos, G S ^a   Eldridge, S R ^b   Bucher, J R ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b CHARLES RIVER LABORATORIES   (United States)

Author keywords

Cell proliferation; Essential oils; Methyleugenol; p Alkoxyallylbenzenes

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; BILE ACID; FLAVORING AGENT; FRAGRANCE; GASTRIN; IDITOL DEHYDROGENASE; METHYLCELLULOSE; METHYLEUGENOL; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID BLOOD LEVEL; CELL PROLIFERATION; CHOLESTASIS; CONTROLLED STUDY; DOSE RESPONSE; ENDOCRINE DISEASE; ENZYME BLOOD LEVEL; FEMALE; FOOD POISONING; GASTRIN BLOOD LEVEL; HISTOPATHOLOGY; HYPOALBUMINEMIA; HYPOPROTEINEMIA; LIVER CELL DAMAGE; LIVER DYSFUNCTION; LIVER TOXICITY; MALE; MICROCYTOSIS; MOUSE; MUCOSA INFLAMMATION; NONHUMAN; PROTEIN METABOLISM; RAT; SEX DIFFERENCE; SPECIES DIFFERENCE; STOMACH GLAND; STOMACH PH; THROMBOCYTOSIS;

ALANINE TRANSAMINASE; ANIMALS; BODY WEIGHT; CELL DIVISION; CYTOTOXICITY TESTS, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; EUGENOL; FEMALE; GASTRIC MUCOSA; GASTRINS; HYDROGEN-ION CONCENTRATION; L-IDITOL 2-DEHYDROGENASE; LIVER; MALE; MICE; MUTAGENS; ORGAN SIZE; ORGAN SPECIFICITY; RATS; RATS, INBRED F344; THROMBOCYTOSIS;

EID: 0035066274     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(00)00143-5     Document Type: Article

References (44)

1. Effect of aluminum and deferoxamine on biliary iron elimination in the rat
2. Individual serum bile acids as early indicators of carbon tetrachloride- and chloroform-induced liver injury
3. Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples
4. Acute toxicity studies with insect attractants
5. The effect of acute protein deprivation upon erythropoiesis in rats
6. The metabolism of naturally occurring hepatocarcinogen safrole to 1′-hydroxysafrole and the electrophilic reactivity of 1′-acetoxysafrole
7. Cell proliferation as a determining factor for the carcinogenicity of chemicals
8. Relationship of hepatocarcinogenicity and hepatocellular proliferation induced by mutagenic noncarcinogens vs. carcinogens II. 1-vs 2-nitropropane
9. Correlation of hepatocellular proliferation with hepatocarcinogenicity induced by mutagenic noncarcinogen:carcinogen pair-2,6-and 2,4-diaminotoluene
10. Anesthetic, hypothermic, myorelaxant and anticonvulsant effects of synthetic eugenol derivatives and natural analogues
11. Multiple comparisons using rank sums
12. A multiple comparison procedure for comparing several treatments with a control
13. Immunochemical detection of covalently modified protein adducts in livers of rats treated with methyleugenol
14. Secretory function of the alimentary tract
15. Subchronic toxicity of cupric sulfate administered in drinking water and feed to rats and mice
16. Clinical enzymology
17. Safrole: Its metabolism, carcinogenicity, and interactions with cytochrome P-450
18. Clinical and laboratory evaluation of anemias and polycythemias
19. Qualitative and quantitative disorders of platelets
20. Serum biochemical changes in rats deprived of food or water for 24 h
21. The pharmacological studies on methyleugenol
22. Regulation of gastrointestinal mucosal growth
23. Microcytic anemia secondary to intraperitoneal aluminum in normal and uremic rats
24. Serum proteins and the dysproteinemias
25. Chronic toxicity of 2,4,6-tri-tert-butylphenol in rats
26. Methotrexate induced changes parotid and submandibular gland function
27. Specific proteins. C. Transport proteins
28. NTP report on the toxicity studies of cupric sulfate (CAS No. 7758-99-8) in F344/N Rats and B6C3F1 Mice (Drinking Water and Feed Studies)
29. Defective iron uptake by the duodenum of Belgrade rats fed diets of different iron contents
30. Pharmacological and toxicological studies on an iron succinyl-protein complex (ITF282) for oral treatment of iron deficiency anemia
31. Testing for increased carcinogenicity using a survival-adjusted quantal response test
32. Polyamine induced suppression of erythropoiesis in uremia
33. The origin of the serum alkaline phosphatase in normal rats
34. Nitrite-induced iron deficiency in the neonatal rat
35. A non-parametric equivalent of Williams' test for contrasting increasing dose levels of a treatment
36. Metabolism of alkylbenzene derivatives in the rat. II. Eugenol and isoeugenol methyl ethers
37. Immunohistochemical detection of bromodeoxyuridine in formalin-fixed tissues
38. A study of the mechanism of butachlor-associated gastric neoplasms in Sprague-Dawley rats
39. Frequency and relationships of clinical chemistry and liver and kidney histopathology findings in 13-week toxicity studies in rats
40. A test for differences between treatment means when several dose levels are compared with a zero dose control
41. The comparison of several dose levels with a zero dose control