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The metabolic activation and carcinogenicity of alkenylbenzenes that occur naturally in many spices
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Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring synthetic alkenylbenzene derivatives related to safrole and estragole
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The side-chain epoxidation and hydroxylation of the hepatocarcinogens safrole and estragole and some related compounds by rat and mouse liver microsomes
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Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1′-sulfooxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1′-hydroxysafrole in mouse liver
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Structures of the DNA adducts formed in mouse liver after administration of the proximate hepatocarcinogen 1′-hydroxyestragole
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N2 atom of guanine and N6 atom of adenine residues as sites for covalent binding of metabolically activated 1′-hydroxysafrole to mouse liver DNA in vivo
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Phillips, D. H., Miller, J. A., Miller, E. C., and Adams, B. (1981) N2 atom of guanine and N6 atom of adenine residues as sites for covalent binding of metabolically activated 1′-hydroxysafrole to mouse liver DNA in vivo. Cancer Res. 41, 2664-2671.
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The metabolic activation of the carcinogen 1′-hydroxysafrole in vivo and in vitro and the electrophilic reactivities of possible ultimate carcinogens
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Carcinogenic and mutagenic activities of safrole, 1′-hydroxysafrole and some known or possible metabolites
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