Transcriptional regulation of the androgen signaling pathway by the wilms' tumor suppressor gene WT1

Anticancer Research

Volumn 21, Issue 1 A, 2001, Pages 1-10

  Zaia, A ^a   Fraizer, G C ^a   Piantanelli, L ^a   Saunders, G F ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Androgen receptor; Androgen signaling pathway; Prostate cancer cell lines; Wilms' tumor suppressor gene

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; GENE PRODUCT; LIPOFECTAMINE; LUCIFERASE; MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE CONSTRUCT; GENE OVEREXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NEPHROBLASTOMA; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; SERTOLI CELL; SIGNAL TRANSDUCTION; TATA BOX; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ANDROGENS; CARCINOMA; CELL LINE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, REPORTER; GENES, WILMS TUMOR; HUMANS; KIDNEY; MALE; METRIBOLONE; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; RESPONSE ELEMENTS; RNA, MESSENGER; SERTOLI CELLS; SIGNAL TRANSDUCTION; TESTOSTERONE CONGENERS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; WT1 PROTEINS;

EID: 0035064929     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Polypeptide modulators of prostatic growth and development
2. Growth factor receptors and prostate cell growth
3. Role of peptide growth factors in the prostate: A review
4. Cellular biology of prostatic growth factors
5. Hormonal factors in sex differentiation of the mammalian foetus
6. Androgenic control of prostatic growth: Regulation of steroid levels
7. Androgen regulation of programmed death of normal and malignant prostatic cells
8. The prostate in eunuchs
9. Endocrine therapy in the management of advanced prostate cancer: The case for early initiation of treatment
10. Role of mesenchymal-epithelial interactions in normal and abnormal development of the mammary gland and prostate
11. Localization of androgen receptors and estrogen receptors in the prostate
12. Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factor and possibly prolactin, but not androgen, on normal rat prostate epithelial cells in serum-free, primary culture
13. Regulation of prostatic growth and function by peptide growth factors
14. A two-step mechanism for the interaction of estradiol with rat uterus
15. Androgen action
16. Androgen receptor: An overview
17. Molecular mechanisms of androgen action
18. DNA regulatory elements for steroid hormones
19. Many transcription factors interact synergistically with steroid receptors
20. Androgen-specific gene activation via a consensus glucocorticoid response element is determined by interaction with nonreceptor factors
21. The stringency and magnitude fo androgen-specific gene activation are combinatorial functions of receptor and nonreceptor binding site sequences
22. Steroidreceptor induction of gene transcription: A two-step model
23. Isolation and characterization of a zinc-finger polypeptide gene at the human chromosome 11 Wilms tumor locus
24. Differential function of Wilms' tumor gene WT1 splice isoforms in transcriptional regulation
25. Products of alternatively spliced transcripts of the Wilms tumor suppressor gene, wt1, have altered DNA binding specificity, and regulate transcription indifferent ways
26. Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing
27. The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene
28. Repression of the insulin-like growth factor II gene by the Wilms' tumor suppressor WT 1
29. Repression of the transforming growth factor-ß1 gene by the Wilms' tumor suppressor WT1 gene product
30. Inhibition of colony-stimulating factor-I promoter activity by the product of the Wilms' tumor locus
31. Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site
32. Repression of the retinoic acid receptor-a gene by the Wilms' tumro suppressor gene product, wt1
33. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis
34. Repression of Pax-2 by WT1 during normal kidney development
35. Regulation of the proto-oncogenes bcl-2 and c-myc by Wilms' tumor suppressor gene WT1
36. Transcriptional repression mediated by the Wilms' tumor gene product
37. Androgen regulation of the insulin-like growth factor-I and estrogen receptor in rat uterus and liver
38. Testosterone induces expression of transforming growth factor-beta 1 in the murine thymus
39. Prostatic epidermal growth factor receptors and their regulation by androgens
40. Identification of 3', 5'-cyclic adenosine monophosphate response element and other cis-acting elements in the human androgen receptor gene promoter
41. The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Mullerian-inhibiting substance, and the androgen receptor
42. The expression of the Wilms' tumor gene, WT1, in the developing mammalian embryo
43. Establishment of two human prostate cancer cell lines derived from a single bone metastasis
44. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
45. Expression pattem of WT1 and GATA-1 in AML with chromosome 16q22 abnormalities
46. GATA-1 transactivates the WT1 hematopoietic specific enhancer
47. Expression of the tumor suppressor gene WT1 in both human and mouse bone marrow
48. Immortalized and tumorigenic adult human prostatic epithelium cell lines: Characteristics and applications. Part I. Cell markers and immortalized nontumorigenic cell lines
49. Pax 8 regulates human WT1 transcription through a novel binding site
50. Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome
51. The prostate: An increasing medical problem
52. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor and epidermal growth factor
53. Autologous down- regulation of androgen receptor messenger ribonucleic acid
54. Regulation of androgen receptor protein and mRNA concentrations by androgens in rat ventral prostate and seminal vesicles and in human hepatoma cells
55. Androgen increases androgen receptor protein while decreasing receptor mRNA in LNCaP cells
56. Regulation of androgen receptor mRNA and protein level by steroid hormones in human mammary cancer cells
57. Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen
58. Hormonal regulation of androgen receptor mRNA in the brain and anteriorpituitary gland of the male rat
59. Transcriptional regulation of androgen receptor gene expression in Sertoli cells and other cell types
60. Regulation of the 5'-flanking region of the mouse androgen receptor gene by cAMP and androgen
61. The mouse androgen receptor is suppressed by the 5'-untranslated region ofthe gene
62. The Wilms' tumor suppressor gene WT1 is negatively autoregulated
63. Alternative splicing and genomic structure of the Wilms tumor gene WT1
64. Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence
65. Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wtl gene transcript
66. DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1
67. Wilms' tumor 1-KTS isoforms induce pS3-independent apoptosis that can be partially rescued by expression of the epidermal growth factor receptors or the insulin receptors