Synthesis and gastrointestinal prokinetic activity of novel benzamide derivatives with amphoteric side chains

Chemical and Pharmaceutical Bulletin

Volumn 49, Issue 4, 2001, Pages 424-436

  Sakaguchi, J ^a   Iwasaki, N ^a   Iwanaga, Y ^a   Saito, T ^a   Takahara, E ^a   Kato, H ^a   Hanaoka, M ^a  

^a Abbott Japan Co Ltd   (Japan)

Author keywords

4 (4 amino 5 chloro 2 methoxybenzoyl)amino) 1 piperidineacetic acid; 5 HT4 agonist; Colon prokinetic activity; Gastroprokinetic activity

Indexed keywords

4 [(4 AMINO 5 CHLORO 2 METHOXYBENZOYL)AMINO] 1 PIPERIDINEACETIC ACID; AMPHOLYTE; BENZAMIDE DERIVATIVE; BUTYL ESTER; CARBOXYLIC ACID DERIVATIVE; CYCLOAMINOCARBOXYLIC ACID; DOPAMINE 2 RECEPTOR BLOCKING AGENT; ESTER DERIVATIVE; PRODRUG; PROKINETIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; DOG; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG MECHANISM; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; SIDE EFFECT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZAMIDES; BRAIN; CHEMISTRY, PHYSICAL; COLON; DOGS; EMETICS; FERRETS; GASTROINTESTINAL MOTILITY; HUMANS; LIVER; MICE; MICE, INBRED ICR; MOLECULAR CONFORMATION; PRODRUGS; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN AGONISTS; STOMACH; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035063375     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.49.424     Document Type: Article

References (17)