Increased pineal Fdopa uptake is related to severity of Parkinson's disease - A PET study

Journal of Pineal Research

Volumn 30, Issue 4, 2001, Pages 213-219

  Ghaemi, Mehran ^a   Rudolf, Jobst ^a   Hilker, Rüdiger ^a   Herholz, Karl ^a   Heiss, Wolf Dieter ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Fdopa; Parkinson's disease; Pineal gland; Positron emission tomography; Sleep disorders

Indexed keywords

FLUORINE 18; LEVODOPA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DIAGNOSTIC IMAGING; DISEASE DURATION; DISEASE SEVERITY; DOPAMINERGIC SYSTEM; FEMALE; GANGLION; HUMAN; MALE; MONOAMINERGIC SYSTEM; NUCLEAR MAGNETIC RESONANCE IMAGING; PARKINSON DISEASE; PATHOPHYSIOLOGY; PINEAL BODY; POSITRON EMISSION TOMOGRAPHY; RATING SCALE; SCORING SYSTEM;

ADULT; AROMATIC-L-AMINO-ACID DECARBOXYLASES; BIOLOGICAL TRANSPORT, ACTIVE; CASE-CONTROL STUDIES; DIHYDROXYPHENYLALANINE; FEMALE; FLUORINE RADIOISOTOPES; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MELATONIN; MIDDLE AGED; PARKINSON DISEASE; PINEAL GLAND; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0035060835     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-079X.2001.300404.x     Document Type: Article

References (40)

1. Hyperactivity of remaining dopaminergic neurons after partial destruction of the nigro-striatal dopaminergic system in the rat
2. Compensatory bilateral changes in dopamine turnover after striatal kainate lesion
3. Dopamine transporter mRNA content in human substantia nigra decreases precipitously with age
4. Dopaminergic sprouting in the rat striatum after partial lesion of the substantia nigra
5. The relationship between locomotor disability, autonomic dysfunction, and the integrity of the striatal dopaminergic system in patients with multiple system atrophy, pure autonomic failure, and Parkinson's disease, studied with PET
6. Melatonin levels in Parkinson's disease: Drug therapy versus electrical stimulation of the internal globus palildus
7. Induction and superinduction of serotonin N-acetyltransferase by adrenergic drugs and denervation in rat pineal organ
8. PET studies of functional compensation in a primate model of Parkinson's disease
9. Melatonindopamine interaction in the striatal projection area of sensorimotor cortex in the rat
10. Unified Parkinson's Disease Rating Scale
11. Circadian secretion pattern of melatonin in de novo Parkinsonian patients: Evidence for phase-shifting properties of L-dopa
12. Slow recovery of human brain MAO B after L-deprenyl (Selegiline) withdrawal
13. Dopamine visualized in the basal ganglia of living man
14. Midbrain 18F-DOPA uptake differs in Parkinson's disease and in Striatonigral Degeneration
15. Status of dopamine in bovine pineal glands and the stimulation of N-acetyltransferase activity by D2-dopaminergic receptor agonist in the rat pineal gland in culture
16. Parkinsonism: Onset, progression and mortality
17. 6-[18F]fluoro-L-dopa metabolism in living human brain: A comparison of six analytical methods
18. Effect of L-dopa on the hypothalamic, pineal and striatal monoamines and the sexual behaviour of the rat
19. Striatal 3,4-dihydroxyphenylalanine decarboxylase in aging: Disparity between postmortem and positron emission tomography studies?
20. The meningeal compartments of the median eminence and the cortex
21. Inhibition of L-[18F]fluorodopa uptake into human brain by amino acids demonstrated by positron emission tomography
22. Ependym und Circumventrikuläre Organe
23. Occurence and distribution of aromatic L-amino acid (L-dopa) decarboxylase in the human brain
24. Nigrostriatal function in humans studied with positron emission tomography
25. Compensatory mechanisms in the nigrostriatal dopaminergic system in Parkinson's disease: Studies in an animal model
26. Vascular permeability to proteins and peptides in the mouse pineal gland
27. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations
28. An interactive technique for three-dimensional image registration: Validation for PET, SPECT, MRI and CT brain studies
29. Frontal, midbrain and striatal dopaminergic function in early and advanced Parkinson's disease. A 3D [18F]dopa-PET study
30. Elevated dopa decarboxylase activity in living brain of patients with psychosis
31. 18F]fluorodopa accumulation after combined inhibition of peripheral catechol-O-methyltransferase and monoamine oxidase type B: Differing response in relation to presynaptic dopaminergic dysfunction
32. Calcium, calcification and melatonin biosynthesis in the human pineal gland: A postmortem study into age-related factors
33. 18F]fluoro-L-dopa in Parkinson's disease measured with positron emission tomography
34. Aromatic L-amino-acid decarboxylase (DOPA decarboxylase) gene expression in dopaminergic and serotoninergic cells of the rat brainstem
35. Chronic L-deprenyl-induced up-regulation of the dopamine uptake carrier
36. Performance evaluation of the positron scanner ECAT EXACT
37. The ECAT EXACT HR: Performance of a new high resolution positron scanner
38. Pharmacokinetics of levodopa
39. Changes of midbrain 18-F-dopa uptake in different stages of Parkinson's disease