Systemic bioavailability of nasally applied chlorphenamine maleate (0.4% nasal spray) relative to tablets administered perorally

International Journal of Clinical Pharmacology and Therapeutics

Volumn 39, Issue 4, 2001, Pages 173-178

  van Toor, B S J ^a   Buchwald, A ^a   Stengele, E ^a   Trenk, D ^a   Gercek, C ^a   de Mey, C M ^a  

^a BAYER AG   (Germany)

Author keywords

Bioavailability; Chlorphenamine maleate; Nasal spray

Indexed keywords

CHLORPHENIRAMINE MALEATE; NOSE SPRAY;

ADULT; ADVERSE DRUG REACTION; AEROSOL; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE TIME EFFECT RELATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; FATIGUE; HUMAN; HUMAN EXPERIMENT; MALE; MEAN RESIDENCE TIME; NORMAL HUMAN; TABLET;

EID: 0035060080     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/cpp39173     Document Type: Article

References (11)

1. Chlorphenamine II. Effect of the first-pass metabolism on the oral bioavailability in dogs
2. Distribution of antihistamines into the CSF following intranasal delivery
3. International consensus report on the diagnosis and management of rhinitis
4. Azelastine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential
5. Levocobastine. An update of its pharmacology, clinical efficacy and tolerability in the topical treatment of allergic rhinitis and conjunctivitis
6. Clinical pharmacokinetics of chlorphenamine
7. 1 receptor antagonists: Clinical pharmacology and therapeutics
8. A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorphenamine versus placebo: Suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects
9. Pharmacological prophylaxis of allergic rhinitis: Relative efficacy of hydroxyzine and chlorphenamine