Beneficial effect of supplementation with copper sulfate on STZ-diabetic mice (IDDM)

Diabetes Research and Clinical Practice

Volumn 52, Issue 2, 2001, Pages 77-84

  Sitasawad, Sandhya ^a   Deshpande, Manisha ^a   Katdare, Mamata ^a   Tirth, Suraj ^a   Parab, Pradeep ^a  

^a NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

interferon; Copper sulfate; Inducible nitric oxide synthase; Insulin dependent diabetes mellitus; Interleukin 4; Lipid peroxidation; Pancreatic cells; Reactive oxygen intermediates; Streptozotocin

Indexed keywords

COPPER SULFATE; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 4; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; TRACE ELEMENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DESTRUCTION; CONTROLLED STUDY; DRUG EFFECT; FEMALE; INSULIN DEPENDENT DIABETES MELLITUS; LIPID PEROXIDATION; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; COPPER SULFATE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FASTING; FEMALE; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERLEUKIN-4; ISLETS OF LANGERHANS; LIPID PEROXIDES; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; SPLEEN;

EID: 0035059234     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8227(00)00249-7     Document Type: Article

References (26)

1. Insulin dependent diabetes mellitus as an autoimmune disease
2. Pathologic anatomy of the pancreas in juvenile diabetes mellitus
3. Pancreatic β cell specific expression of Thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin induced diabetes
4. Cytokines and free radicals as effector molecules in the destruction of pancreatic β cells
5. Roles of cytokines in IDDM pathogenesis and islet β cell destruction
6. Nitric oxide mediate autoimmune destruction of β cells? Possible therapeutic interventions in IDDM
7. Changes in superoxide dismutase mRNA expression by streptozotocin induced diabetes
8. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
9. Early macrophages infiltration in mice treated with low-dose streptozotocin decreases islet superoxide dismutase levels: prevention by silica pretreatment
10. The role of dietary zinc in modifying the onset and severity of spontaneous diabetes in the BB Wistar rat
11. Effector mechanisms in low dose streptozotocin induce diabetes
12. Large scale isolation of islets by tissue culture of adult mouse pancreas
13. Mouse islet cell lysis mediated by interleukin-l-induced Fas
14. Cloning and expression of murine immune interferon cDNA
15. Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes
16. Radiation effects on membranes I. Vitamin E deficiency and lipid peroxidation
17. Transcriptional regulation of interleukin-2 gene expression is impaired by copper deficiency in Jurkat human T lymphocytes
18. Metal-induced modulation of nitric oxide production in vitro by murine macrophages: lead, nickel, and cobalt utilize different mechanisms
19. Nitric oxide primes pancreatic β cells for Fas-mediated destruction in insulin dependent diabetes mellitus
20. Nitric oxide mediates cytokine-induced secretion by human islets of Langerhans
21. Nitric oxide in autoirumune disease: cytotoxic or regulatory mediator?
22. Plasma, granulocyte and mononuclear cell copper and zinc in patients with diabetes mellitus
23. Hypoglycemic effect of copper (II) acetate imidazole complexes
24. Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity