Venom as a source of useful biologically active molecules

Emergency Medicine

Volumn 13, Issue 1, 2001, Pages 28-36

  Bailey, Paul ^a,b   Wilce, Jacqueline ^a,b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b SIR CHARLES GAIRDNER HOSPITAL   (Australia)

Author keywords

Drug design; Ion channel; Structural studies; Toxin structure; Venom

Indexed keywords

CAPTOPRIL; CONOTOXIN; METALLOPROTEINASE INHIBITOR; SNAKE VENOM; SODIUM CHANNEL; SPIDER VENOM; VENOM;

DRUG DESIGN; EMERGENCY MEDICINE; ENVENOMATION; INSECT CONTROL; JELLYFISH; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REVIEW; SEA ANEMONE; TOXIN STRUCTURE; X RAY CRYSTALLOGRAPHY;

ARTHROPOD VENOMS; AUSTRALIA; DRUG DESIGN; HUMANS; ION CHANNEL GATING; MARINE TOXINS; SNAKE VENOMS; STRUCTURE-ACTIVITY RELATIONSHIP; VENOMS;

EID: 0035057544     PISSN: 10356851     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1442-2026.2001.00174.x     Document Type: Review

References (30)

1. Toxinology research and clinical controversies: An Australian perspective
2. The lethality in mice of dangerous Australian and other snake venom
3. Condylactis toxin: Interaction with nerve membrane ionic conductances
4. Sea anemone toxin: A tool to study molecular mechanisms of nerve conduction and excitation-secretion coupling
5. Biologically active compounds from coelenterates
6. Potent cardiotonic action of polypeptides isolated from sea anemone
7. The effects of anthopleurine-A on cardiac dynamics in conscious dogs
8. Polypeptide modulators of sodium channel function as a basis for the development of novel cardiac stimulants
9. Structure and function of voltage-sensitive ion channels
10. Structure and structure-function relationships of sea anemone proteins that interact with the sodium channel
11. Determination of the 3-D solution structure of the antihypertensive and antiviral protein BDS-1 from the sea anemone Anemnia sulcata: A study using nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing
12. Binding of the sea anemone polypeptide BDS II to the voltage gated sodium channel
13. Sea anemone toxin and scorpion toxin share a common receptor site associated with the action potential sodium ionophore
14. Structural and dynamic characterization of omega-Conotoxin MVIIA. The binding loop exhibits slow conformational exchange
15. Conotoxins and their potential pharmaceutical applications
16. Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats
17. Ziconotide, a new N-type calcium channel blocker, administered intrathecally for acute postoperative pain
18. Effects of an N-type calcium channel antagonist (SNX 111; ziconotide) on calcium-45 accumulation following fluid-percussion injury
19. Ziconotide for the treatment of severe spasticity after spinal cord injury
20. The structure of a novel insecticidal neurotoxin, omega-atracotoxin-HV1, from the venom of an Australian funnel web spider
21. The cDNA sequence of an excitatory insect selective neurotoxin from the scorpion Buthus martensi Karsch
22. Molecular cloning of a cDNA encoding insecticidal neurotoxic peptides from the spider Phoneutria nigriventer
23. Effects of a centipede venom fraction on insect nervous system, a native Xenopus oocyte receptor and on an expressed Drosophilia muscarinic receptor
24. Efficacy of recombinant baculoviruses expressing insect-selective toxins
25. Characterisation of antibacterial activity of peptides isolated from the venom of the spider Cupiennius salei
26. Antibacterial properties of KwaZulu Natal snake venoms
27. A dipeptidyl carboxypeptidase that converts angiotensin-I and inactivates bradykinin
28. The discovery of captopril: From animals to small molecules
29. Development and design of specific inhibitors of angiotensin-converting enzyme