Evaluation of potential tracer ability of 99mTc-labeled acetylated LDL for scintigraphy of LDL-scavenger receptor sites of macrophageal origin

Nuclear Medicine and Biology

Volumn 28, Issue 3, 2001, Pages 235-241

  Gurudutta, G U ^a   Babbar, A K ^a   Shailaja, S ^a   Soumya, P ^a   Sharma, R K ^a  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

99mTc Ac LDL; 99mTc Na LDL; Acetylated low density lipoprotein (Ac LDL); Macrophages scintigraphy; Native low density lipoprotein (Na LDL); Scavenger receptors

Indexed keywords

ACETYL LOW DENSITY LIPOPROTEIN; NATIVE LOW DENSITY LIPOPROTEIN; RADIOPHARMACEUTICAL AGENT; SCAVENGER RECEPTOR; SODIUM DITHIONITE; UNCLASSIFIED DRUG;

ABSCESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROTIC PLAQUE; BIOAVAILABILITY; CONTROLLED STUDY; IMAGING; INFLAMMATION; ISOTOPE LABELING; KIDNEY TUBULE ABSORPTION; MACROPHAGE; MOUSE; MUSCLE; NONHUMAN; ORGAN DISTRIBUTION; PLASMA CLEARANCE; PLASMA PROTEIN BINDING; PROTEIN LOCALIZATION; RABBIT; RECEPTOR BINDING; SCINTIGRAPHY;

ACETYLATION; ANIMALS; DRUG STABILITY; LIPOPROTEINS, LDL; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; RABBITS; RADIOPHARMACEUTICALS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LDL; RECEPTORS, LIPOPROTEIN; RECEPTORS, SCAVENGER; SCAVENGER RECEPTORS, CLASS B; SODIUM PERTECHNETATE TC 99M; TISSUE DISTRIBUTION;

EID: 0035056014     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(00)00185-2     Document Type: Article

References (31)

1. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells
2. Protein kinase-C activity is required for lipid oxidation of low-density lipoprotein by activated human monocytes
3. Endothelial and smooth muscle cells alter low-density lipoprotein in vivo by free radical oxidation
4. A receptor-mediated pathway for cholesterol homeostasis
5. Beneficial effect of cholesterol lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolemic patients
6. Suppression of 3-hydroxy-3-methyl glutaryl coenzyme-A reductase activity and inhibition of growth of human fibroblasts by 7-keto-cholesterol
7. Modification of low-density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low-density lipoprotein phospholipid
8. Endothelium and coronary atherosclerosis
9. The low-density lipoproteins pathway and its relation to atherosclerosis
10. The low-density lipoprotein receptor hypothesis
11. Binding site on macrophages that mediate uptake and degradation of acetylated low-density lipoprotein producing massive cholesterol deposition
12. Effects of oxidized low-density lipoproteins on vascular contraction and relaxation: Clinical and pharmacological implications in atherosclerosis
13. Oxidatively modified low-density lipoproteins: A potential role in recruitment and retention of monocyte macrophages during atherosclerosis
14. Transcriptional regulation of endothelial cell adhesion molecules: NF-Bk and cytokine-inducible enhancers
15. Circumferential stress and matrix metalloproteinase I in human coronary atherosclerosis. Implications for plaque rupture
16. Cytokines regulate vascular functions related stability of the atherosclerotic plaque
17. 99mTc-Ac-LDL to image sites localised by cells bearing scavenger receptor
18. Degradation of cataionised low-density lipoproteins and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts
19. Technetium-99m low-density lipoproteins: Preparations and biodistribution
20. Technetium-99m labeled monoclonal antibodies: Evaluation of reducing agents
21. 99mTc-low-density lipoproteins: Intracellularly trapped radiotracers for non-invasive imaging of low-density lipoprotein metabolism in vivo
22. Partial characterization of low density lipoprotein preparations isolated from fresh and frozen plasma after radiolabeling by seven different methods
23. Imaging of hepatic low-density lipoprotein receptors by radionuclide scintiscanning in vivo
24. 131I-tyramine cellobiose-LDL
25. Lipoproteins and lipid transport
26. Rapid uptake by liver sinusoidal cells of serum albumin modified with retention of its compact conformation
27. Receptor mediated catabolism of low density lipoproteins in man: Quantification using glycosylated low density lipoproteins
28. Role of lysosomal acid lipases in the metabolism of plasma low density lipoproteins: Observations in cultured fibroblasts from a patient with cholesterol ester storage diseases
29. Synergistic transcriptional activities of IL-8 gene by Nk-BK, p65 (Rel A) and NF-IL-6
30. 99mTechnetium-labeled low-density lipoproteins receptor recognition and intracellular sequestration of radiolabel
31. A macrophage receptor for oxidised low-density lipoprotein distinct from the receptor for acetylated low-density lipoprotein: Partial purification and role in recognition of oxidatively damaged cells