Pharmacokinetics and pharmacodynamics of ranitidine in critically ill children

Critical Care Medicine

Volumn 29, Issue 4, 2001, Pages 759-764

  Lugo, Ralph A ^a,b   Harrison, A Marc ^c   Cash, Jared ^a,b   Sweeley, John ^a,b   Vernon, Donald D ^d  

^a UNIVERSITY OF UTAH   (United States)

^b PRIMARY CHILDREN'S MEDICAL CENTER   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Critical care; Gastrointestinal hemorrhag; Histamine H2 antagonist; Intensive care units pediatric; Metabolis; Pharmacokinetic; Ranitidin

Indexed keywords

PLACEBO; RANITIDINE;

ADOLESCENT; ARTICLE; BLOOD SAMPLING; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CRITICAL ILLNESS; DIGESTIVE SYSTEM HEMORRHAGE; DOSE RESPONSE; DRUG EFFECT; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTENSIVE CARE UNIT; INTESTINE MUCOSA PERMEABILITY; MALE; PH MONITORING; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; STOMACH PH;

EID: 0035050762     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200104000-00014     Document Type: Article

References (38)

1. Prevention of stress ulcer bleeding: A review
2. Upper gastrointestinal tract bleeding in critically ill pediatric patients
3. Frequency and prophylaxis of upper gastrointestinal hemorrhage in critically ill children: A prospective study comparing the efficacy of almagate, ranitidine, and sucralfate
4. Clinically significant upper gastrointestinal bleeding acquired in a pediatric intensive care unit: A prospective study
5. Prevalence of, and risk factors for, upper gastrointestinal tract bleeding in critically ill pediatric patients
6. Frequency of upper gastrointestinal bleeding in a pediatric intensive care unit
7. Pediatric risk of mortality (PRISM) score
8. Acute stress ulceration
9. Stress ulcer prophylaxis in the critically ill: A metaanalysis
10. Ranitidine prophylaxis in acute gastric mucosal damage in critically ill pediatric patients
11. A randomized, controlled study of prophylactic ranitidine in preventing stress-induced gastric mucosal lesions in neonatal intensive care unit patients
12. Attitude of pediatric intensivists toward prophylaxis of upper gastrointestinal bleeding
13. Gastric pH control in critically ill children receiving intravenous ranitidine
14. Effects of two dosing regimens of intravenous ranitidine on gastric pH in critically ill children
15. Use of ranitidine in children undergoing cardiopulmonary bypass
16. Antacid versus cimetidine in preventing acute gastrointestinal bleeding. A randomized trial in 75 critically ill patients
17. A comparison of two ranitidine intravenous infusion regimens in critically ill patients
18. Randomised, prospective trial of cimetidine and ranitidine for control of gastric pH in the critically ill
19. Stress ulceration in the critically ill patient
20. Control and variability of gastric pH in critically ill children
21. Acute gastroduodenal disease after thermal injury. An endoscopic evaluation of incidence and natural history
22. Cimetidine for prevention and treatment of gastroduodenal mucosal lesions in patients in an intensive care unit
23. Pharmacokinetics of ranitidine in critically ill patients
24. Ranitidine pharmacokinetics in newborn infants
25. Pharmacokinetics of ranitidine in critically ill infants
26. Automated liquid chromatographic determination of ranitidine in microliter samples of rat plasma
27. PRISM III: An updated pediatric risk of mortality score
28. The prevention of upper gastrointestinal tract bleeding in patients in an intensive care unit
29. National survey of stress ulcer prophylaxis
30. Clinical pharmacokinetics of ranitidine
31. The use of intravenous ranitidine in stressed children
32. Pharmacokinetics and pharmacodynamics of ranitidine in neonates treated with extracorporeal membrane oxygenation
33. Update: Clinically significant cytochrome P-450 drug interactions
34. Influence of phenobarbital treatment on cimetidine kinetics
35. Control of gastric pH with cimetidine: Bolus versus primed infusions
36. Effect of neurotrauma on hepatic drug clearance