Endothelin antagonists in the treatment of renal failure

Current Opinion in Investigational Drugs

Volumn 2, Issue 4, 2001, Pages 513-520

  Pollock, D M ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Acute renal failure; Chronic renal failure; Endothelin receptor antagonists; Renal hemodynamics

Indexed keywords

2 [[2 [[2 [[(HEXAHYDRO 1H AZEPIN 1 YL)CARBONYL]AMINO] 4 METHYLPENTANOYL]AMINO] 3 (1 METHYL 1H INDOL 3 YL)PROPIONYL]AMINO] 3 (2 PYRIDYL)PROPIONIC ACID; 3 (2 CARBOXYMETHOXY 4 METHOXYPHENYL) 1 (3,4 METHYLENEDIOXYPHENYL) 5 PROPOXY 2 INDANCARBOXYLIC ACID; BOSENTAN; CREATININE; CYCLOSPORIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; ENDOTOXIN; IMMUNOSUPPRESSIVE AGENT; N ACETYL 3,3 DIPHENYL DEXTRO ALANYLLEUCYLASPARTYLISOLEUCYLISOLEUCYLTRYPTOPHAN; TAK 044; TRANSFORMING GROWTH FACTOR BETA1;

ACUTE KIDNEY FAILURE; AUTOCRINE EFFECT; CHRONIC KIDNEY FAILURE; CLINICAL TRIAL; DISEASE MODEL; DIURESIS; DRUG EFFECT; DRUG STRUCTURE; GLOMERULONEPHRITIS; GLOMERULUS FILTRATION RATE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KIDNEY BLOOD FLOW; KIDNEY DISEASE; KIDNEY FAILURE; KIDNEY MEDULLA; KIDNEY TUBULE ABSORPTION; NONHUMAN; PARACRINE SIGNALING; PATHOGENESIS; PATHOPHYSIOLOGY; RECEPTOR BLOCKING; RECEPTOR INTRINSIC ACTIVITY; REVIEW; SODIUM EXCRETION; VASOCONSTRICTION; VASODILATATION;

ANIMALS; ENDOTHELIN-1; HUMANS; KIDNEY; KIDNEY FAILURE; VASOCONSTRICTION;

EID: 0035050144     PISSN: 09678298     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (117)

1. Regulation of endothelin production and secretion in cultured collecting duct cells by endogenous transforming growth factor-β
2. Synthesis and secretion of endothelin in a cortical collecting duct cell line
3. Regulation of endothelin-1 production in cultured rat mesangial cells
4. Production of endothelin-1 by rat mesangial cells: Regulation by tumor necrosis factor
5. Regulated expression of endothelin 1 in glomerular capillary endothelial cells
6. Endothelin-1 mRNA in glomerular and epithelial cells of kidney
7. Presence and distribution of endothelin-1 gene expression in human kidney
8. Localization of endothelin-like immunoreactivity in rat kidneys
9. Endothelin peptides and receptors in human kidney
10. Immunoreactive endothelin in human kidney
11. Characterization of endothelin 1 receptor and signal transduction mechanisms in rat medullary interstitial cells
12. Immunoreactive endothelin in rat kidney inner medulla: Marked decrease in spontaneously hypertensive rats
13. Organ distribution of the three rat endothelin messenger RNAs and the effects of ischemia on renal gene expression
14. Endothelin-1 mRNA expression in the rat kidney
15. Autoradiographic localisation of endothelin binding sites in kidney
16. Localization of endothelin receptors in the rat kidney
17. Endothelin receptors in cultured renal epithelial cells
18. B in human kidney
19. 125I]IRL-1620, a potent agonist specific for endothelin-B receptors
20. A receptor-mediated responses to endothelin-1 and big endothelin-1 in the rat kidney
21. A receptors in the perfused rabbit kidney
22. A receptor antagonism with ABT-627 attenuates all renal effects of endothelin in humans
23. Differential regulation of renal regional blood flow by endothelin-1
24. Use of the endothelin antagonists BQ-123 and PD 142893 to reveal three endothelin receptors mediating smooth muscle contraction and the release of EDRF
25. Evidence for endothelin involvement in the response to high salt
26. A receptor activation
27. B receptor-mediated constriction in the renal microcirculation of rats
28. Differential sensitivity to endothelin in canine arteries and veins
29. Different endothelin receptor subtypes are involved in phospholipid signalling in the proximal tubule of rat kidney
30. Characterization of endothelin receptors in the inner medullary collecting duct of the rat
31. Endothelin synthesis by rabbit renal tubule cells
32. Endothelin-1 is an autocrine factor in rat inner medullary collecting ducts
33. Endothelin's biphasic effect on fluid absorption in the proximal straight tubule and its inhibitory cascade
34. 2+-dependent pathway in OKP cells
35. B receptor activation of NHE3
36. B receptor activation leads to activation and phosphorylation of NHE3
37. B receptor-mediated NO release
38. +-ATPase in intact renal tubular epithelial cells
39. Induction of water diuresis by endothelin in rats
40. B receptor
41. Haemodynamic and renal tubular effects of low doses of endothelin in anaesthetized rats
42. Upregulation of endothelin B receptors in kidneys of DOCA-salt hypertensive rats
43. Salt-sensitive hypertension in ANP knockout mice: Potential role of abnormal plasma renin activity
44. Rat renal, aortic and pulmonary endothelin-1 receptors: Effects of changes in sodium and water intake
45. Increased renal medullary endothelin-1 synthesis in prehypertensive DOCA- and salt-treated rats
46. Salt-sensitive hypertension in endothelin-B receptor-deficient rats
47. Effect of different endothelin receptor antagonists and of the novel non-peptide antagonist Ro 46-2005 on endothelin levels in rat plasma
48. B receptors in rats
49. Pathophysiological role of endothelin in acute renal failure
50. Rat kidney endothelin receptors in ischemia-induced acute renal failure
51. Endothelin up-regulation and localization following renal ischemia and reperfusion
52. Endothelial dysfunction in acute renal failure: Role of circulating and tissue endothelin-1
53. Protective effect of a selective endothelin receptor antagonist, BQ-123, in ischemic acute renal failure in rats
54. Nonpeptide endothelin receptor antagonists. V: Prevention and reversal of acute renal failure in the rat by SB 209670
55. Biological role for the endothelin-A receptor in aortic cross-clamping
56. B endothelin antagonist, L-754,142, after aortic cross-clamping in the dog
57. Improvement of postischemic acute renal failure with the novel orally active endothelin-A receptor antagonist LU 135252 in the rat
58. Protective effects of endothelin receptor antagonists in dogs with aortic cross-clamping
59. Protective effect of SM-19712, a novel and potent endothelin converting enzyme inhibitor, on ischemic acute renal failure in rats
60. Effects of ioversol versus iothalamate on endothelin release and radiocontrast nephropathy
61. Radiocontrast agents induce endothelin release in vivo and in vitro
62. Radiocontrast increases plasma and urinary endothelin
63. Incidence, risk factors and clinical course of acute renal insufficiency after cardiac catheterization in patients 70 years of age or older
64. Radiocontrast-induced nephropathy in humans: Role of renal vasoconstriction
65. Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction
66. A receptor blockade in a rat model of radiocontrast-induced nephropathy
67. Effect of endothelin in radiocontrast-induced nephropathy in rats are mediated through endothelin-A receptors
68. Blockade of radiocontrast-induced nephrotoxicity by the endothelin receptor antagonist, SB 209670
69. Exacerbation of radiocontrast nephrotoxicity by endothelin receptor antagonism
70. Endothelin receptor antagonism is protective in in vivo acute cyclosporine toxicity
71. Endothelin A receptor mediates functional but not structural damage in chronic cyclosporine nephrotoxicity
72. Cellular mechanisms of cyclosporine A-associated side-effects: Role of endothelin
73. Combined antagonism of endothelin A/B receptors links endothelin to vasoconstriction whereas angiotensin II effects fibrosis. Studies in chronic cyclosporine nephrotoxicity in rats
74. Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay
75. Tissue expression of endothelin-1 mRNA in endotoxaemia
76. Endotoxin-mediated changes in plasma endothelin concentrations, renal endothelin receptor and renal function
77. Pathophysiologic role of endothelin-1 in renal function in rats with endotoxin shock
78. Possible involvement of endothelin peptides and L-arginine-nitric oxide pathway on the effect of endotoxin in the rabbit isolated perfused kidney
79. Improvement of renal dysfunction in dogs with endotoxemia by a nonselective endothelin receptor antagonist
80. Progression of proteinuric diabetic and nondiabetic diseases: A possible role for renal endothelin
81. Endothelin in the progressive renal disease of glomerulopathies
82. Role of endothelin in renal function and dysfunction
83. Endothelin blockers and renal protection: A new strategy to prevent end-organ damage in cardiovascular disease?
84. Increased renal endothelin production in rats with reduced renal mass
85. Renal endothelin gene expression is increased in remnant kidney and correlates with disease profession
86. Increased endothelin excretion in rats with renal failure induced by partial nephrectomy
87. A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression
88. A receptor blockade prevents the progression of renal failure and hypertension in uraemic rats
89. Protective effects of endothelin antagonists in chronic renal failure
90. Increased immunoreactive endothelin-1 levels in blood vessels and glomeruli of rats with reduced renal mass
91. Role of endothelin in hypertension of experimental chronic renal failure
92. Alterations in renal endothelin production in rats with reduced renal mass
93. A receptor blockade prevents hypertension associated with exogenous endothelin-1 but not renal mass reduction in the rat
94. Acute changes of endothelin 1 in children on hemodialysis
95. Increased endothelin-1 mRNA expression in peripheral blood monocytes of dialysis patients
96. Increased endothelin-1 content in the platelets of hemodialysed patients
97. Modulation of endothelin family gene expression in renal hypertrophy
98. Plasma endothelin levels in hypertension and chronic renal failure
99. Urinary excretion of endothelin-1 in normal subjects and patients with renal disease
100. Endothelin-1 and endothelin B type receptor are induced in mesangial proliferative nephritis in the rat
101. Immunohistochemical distribution of endothelin in biopsies of pediatric nephrotic syndrome
102. Modulation of glomerular endothelin and endothelin receptor gene expression in aminonucleoside-induced nephrosis
103. Urinary endothelin in glomerulonephritis patients with normal renal function
104. Endothelin modulates angiotensin II-induced mitogenesis of human mesangial cells
105. Endothelin modulates the mitogenic effect of PDGF on glomerular mesangial cells
106. Endothelin-1 mediates erythropoietin-stimulated glomerular endothelial cell-dependent proliferation of mesangial cells
107. Effect of a specific endothelin A receptor antagonist on murine lupus nephritis
108. Role of endothelin as a mitogen in experimental glomerulonephritis in rats
109. TGF-β in kidney fibrosis: A target for gene therapy
110. Effect of renin-angiotensin inhibition on glomerular injuries in DOCA-salt hypertensive rats
111. Messenger RNA expression and synthesis of endothelin-1 along rat nephron segments
112. Transforming growth factor-β: Role in mediating serum-induced endothelin production by vascular endothelial cells
113. Trophic effect of angiotensin II in neonatal rat cardiomyocytes: Role of endothelin-1 and non-myocyte cells
114. Endothelin and restenosis
115. Mechanism of progression of renal disease: Growth factors and related mechanisms
116. An endothelin-transforming growth factor beta pathway in the nephrotoxicity of immunosuppressive drugs
117. B receptor antagonist ameliorates proteinuria and glomerular lesions in rats with proliferative nephritis