Primary focal segmental glomerulosclerosis: A treatable lesion with variable outcomes

Nephrology

Volumn 6, Issue 2, 2001, Pages 47-56

  Korbet, Stephen M ^a,b   Schwartz, Melvin M ^b  

^a Section of Nephrology   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Focal glomerulosclecosis; Glomerulosclerosis; Nephrotic syndrome; Primary glomerulopathy; Proteinuria

Indexed keywords

CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTOTOXIC AGENT; DIAMORPHINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IMMUNOSUPPRESSIVE AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISONE; STEROID;

CLINICAL FEATURE; DISEASE CLASSIFICATION; DISEASE COURSE; DRUG INDUCED DISEASE; FOCAL GLOMERULOSCLEROSIS; HISTOPATHOLOGY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY DYSPLASIA; MORBID OBESITY; NEPHROTIC SYNDROME; PATHOGENESIS; PLASMAPHERESIS; PRIORITY JOURNAL; PROLIFERATIVE GLOMERULONEPHRITIS; PROTEINURIA; REFLUX NEPHROPATHY; RELAPSE; REMISSION; REVIEW; SICKLE CELL ANEMIA;

EID: 0035049949     PISSN: 13205358     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1797.2001.00037.x     Document Type: Review

References (69)

1. A hitherto undescribed vulnerability of the juxta-medullary glomeruli in lipoid nephrosis
2. The primary nephrotic syndrome of childhood: Classification and clinicopathologic study of 406 cases
3. The primary nephrotic syndrome in children Identification of patients with minimal change nephrotic syndrome from initial response to prednisone
4. Focal glomerulosclerosis: Natural history and treatment
5. The racial prevalence of glomerular lesions in nephrotic adults
6. Increasing incidence of focal-segmental glomerulosclerosis among adult nephropathies: A 20-year renal biopsy study
7. The enigma of focal segmental glomerulosclerosis
8. Racial differences in the prevalence and presentation of glomerular disease in adults
9. Changing etiologies of unexplained adult nephrotic syndrome: A comparison of renal biopsy findings from 1976-1979 and 1995-1997
10. Idiopathic collapsing focal segmental glomemlosclerosis: A clinicopathologic study
11. The many masks of focal segmental glomerulosclerosis
12. Recurrent focal sclerosis after renal transplantation
13. The nephrotic syndrome: Minimal change disease, focal segmental glomerulosclerosis and miscellaneous causes
14. Primary focal segmental glomerulosclerosis: Pathology, histologic variants, and pathogenesis
15. Primary focal segmental glomerular sclerosis in adults: Prognostic value of histologic variants
16. The glomerular tip lesion: A previously undescribed type of segmental glomerular abnormality
17. Focal segmental glomerular sclerosis: The cellular lesion
18. Collapsing glomerulopathy: A clinically and pathologically distinct variant of focal segmental glomerulosclerosis
19. Nephrotic syndrome, progressive irreversible renal failure and glomerular 'collapse': A new clinicopathologic entity?
20. Collapsing glomerulopathy: Expanding interest in a shrinking tuft
21. The dysregulated podocyte phenotype: A novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy
22. Focal segmental glomerulosclerosis: Prognostic implications of the cellular lesion
23. Primary focal segmental glomerulosclerosis
24. Primary focal segmental glomerulosclerosis
25. Primary focal segmental glomerulosclerosis: Clinical course and response to therapy
26. Focal segmental glomerular sclerosis in adults: Presentation, course and response to treatment
27. The long-term prognosis of patients with focal segmental glomerulosclerosis
28. Significance of proteinuria on the outcome of renal function in patients with focal segmental glomerulosclerosis
29. Focal segmental glomerulosclerosis with rapid decline in renal function ('malignant FSGS')
30. The prognosis of focal segmental glomerular sclerosis of adulthood
31. Long-term prognosis of focal sclerosing glomerulonephritis: An analysis of 250 cases with particular regard to tubulointerstitial changes
32. Evidence suggesting under-treatment in adults with idiopathic focal segmental glomerulosclerosis
33. Focal segmental glomerulosclerosis with and without nephrotic syndrome in children
34. Further studies on the glomerular tip lesion: Early and late stages and life table analysis
35. Can prolonged treatment improve the prognosis in adults with focal segmental glomerulosclerosis?
36. Long-term outcome in children and adults with classic focal segmental glomerulosclerosis
37. The impact of prolonged immunosuppression on the outcome of idiopathic focal-segmental glomerulosclerosis with nephrotic syndrome in adults. A collaborative retrospective study
38. Adult lipoid nephrosis: Clinicopathological correlations
39. Evaluation and correlation of clinical and histological features of focal segmental glomerulosclerosis
40. Idiopathic adult focal segmental glomerulosclerosis: A clinicopathological study and response to steroid
41. Long-term renal tolerance of cyclosporin A treatment in adult idiopathic nephrotic syndrome
42. Steroid therapy and prognosis of focal segmental glomerulosclerosis in the elderly
43. Treatment of corticoresistant idiopathic nephrotic syndrome in the adult: Minimal change disease and focal segmental glomerulosclerosis
44. Cyclophosphamide does not benefit patients with focal segmental glomerulosclerosis: A report of the International Study of Kidney Disease in Children
45. Treatment of nephrotic syndrome with cyclosporin A What remains in?
46. A randomized trial of cyclosporine in steroid resistant idiopathic nephrotic syndrome
47. A randomized trial of cyclosporine in patients with steroid-resistant focal segmental glomerulosclerosis
48. A randomized double-blind placebo-controlled trial of cyclosporine in steroid-resistant idiopathic focal segmental glomerulosclerosis in children
49. Long-term benificial effects of angiotensin-converting enzyme inhibition in patients with nephrotic proteinuria
50. Reduction of proteinuria with captopril therapy in patients with focal segmental glomerulosclerosis and IgA nephropathy
51. Effects of ACE inhibition in normotensive patients with chronic glomerular disease and normal renal function
52. Chronic proteinuric nephropathies: Outcomes and response to treatment in a prospective cohort of 352 patients with different patterns of renal injury
53. Randomized placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, nondiabetic nephropathy
54. Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency
55. Effect of plasma protein adsorption on protein excretion in kidney-transplant recipients with recurrent nephrotic syndrome
56. Plasmapheresis reduces proteinuria and serum capacity to injure glomeruli in patients with recurrent focal glomerulosclerosis
57. Plasmapheresis in the treatment of steroid-resistant focal segmental glomerulosclerosis in native kidneys
58. Plasma immunadsorption treatment in patients with primary focal and segmental glomerulosclerosis
59. Adding plasmapheresis to corticosteroids and alkylating agents: Does it benefit patients with focal segmental glomerulosclerosis?
60. Pathogenesis and significance of nonprimary focal and segmental glomerulosclerosis
61. WT1 and PAX2 podocyte expression in Denys-Drash syndrome and isolated diffuse mesangial sclerosis
62. Renal transplant pathology
63. Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis
64. Pathogenesis of polycation-induced alteration (fusion) of glomrular epithelium
65. Polycation-induced dislocation of slit diaphragms and formation of cell junctions in rat kidney glomeruli. The effects of low temperature, divalent cations, colchicine and cytochalasin B
66. Epitope-specific antibodies to the 43-kD glomerular membrane protein podoplanin cause proteinuria and rapid flattening of podocytes
67. Alteration of glomerular permeability to macromolecules induced by cross-linking of beta-1 integrin receptors
68. Recurrent focal segmental glomerulosclerosis. A patholgical study of the early lesion
69. Recurrent nephrotic syndrome in renal allografts