MKP-1 as a target for pharmacological manipulations in PC12 cell survival

Neurochemistry International

Volumn 39, Issue 1, 2001, Pages 25-32

  Rumora, Lada ^a,b   Shaver, Alan ^a   Žanić Grubišić, Tihana ^b   Maysinger, Dusica ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

FK506; Mitogen activated protein kinase; Mitogen activated protein kinase phosphatase 1; PC12 cells; Peroxovanadium compounds

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; MONOPEROXO(NITRILOTRIACETIC)OXOVANADATE; MONOPEROXO(PYRIDINE 2 CARBOXILATO)OXOVANADATE; MONOPEROXO(PYRIDINE 2,6 DICARBOXYLATO)OXOVANADATE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; TACROLIMUS; UNCLASSIFIED DRUG; VANADIUM DERIVATIVE;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0035044414     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(01)00004-3     Document Type: Article

References (37)

1. Calcineurin and mitohondrial function in glutamate-induced neuronal cell death
2. In vivo insulin mimetic effects of pV compounds: Role for tissue targeting in determining potency
3. Induction of mitogen-activated protein kinase phosphatase 1 by the stress-activated protein kinase signaling pathway but not by extracellular signal-regulated kinase in fibroblasts
4. Regulation of mitogen-activated protein kinase phosphatase-1 in vascular smooth muscle cells
5. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
6. Activation of MAPK by potassium bisperoxo(1,10-phenanthroline)oxovanadate (V)
7. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmarker mutation
8. PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation
9. Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotectiva against UV-induced apoptosis
10. Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506
11. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
12. Activation of the mitogen-activated protein kinase pathway induces transcription of the PAC-1 phosphatase gene
13. FK506 prevents stroke-induced generation of ceramide and apoptosis signaling
14. Protective effect of cyclosporin A and FK506 from nitric oxide-dependent apoptosis in activated macrophages
15. Rapamycin potentiates dexamethasone-induced apoptosis and inhibits JNK activity in lymphoblastoid cells
16. Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase
17. Pervanadate-triggered MAP kinase activation and cell proliferation are not sensitive to PD 98059
18. Inhibition of CREB- and cAMP response element-mediated gene transcription by the immunosuppressive drugs cyclosporin A and FK506 in T cells, Naunyn Schmiedeberg's
19. Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress
20. Specificity of receptor tyrosin kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
21. From Vanadis to Atropos: Vanadium compounds as pharmacological tools in cell death signaling
22. The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases
23. Lymphocyte activation: The coming of the protein tyrosine phosphatases
24. Peroxovanadium compounds
25. Effects of the immunosuppressive drugs CsA and FK506 on intracellular signaling and gene regulation
26. Vanadium salts as insulin substitutes: Mechanisms of action, a scientific and therapeutic tool in diabetes mellitus research
27. The chemistry of peroxovanadium compounds relevant to insulin mimesis
28. Insulin-like stimulation of glucose oxidation in rat adipocytes by vanadyl (IV) ions
29. The calcium/calmodulin-dependent protein phosphatase calcineurin is the major Elk-1 phosphatase
30. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
31. Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1
32. Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin)
33. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor
34. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor
35. MAP kinase phosphatase 1 is expressed and enhanced by FK506 in surviving mamillary, but not degenerating nigral neurons following axotomy
36. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
37. FK506 antagonizes apoptosis and c-jun protein expression in neuronal cultures