Metabolism of sulfinpyrazone sulfide and sulfinpyrazone by human liver microsomes and cDNA-expressed cytochrome P450s

Drug Metabolism and Disposition

Volumn 29, Issue 5, 2001, Pages 701-711

  He, Minxia ^a,b   Rettie, Allan E ^a   Neal, John ^a   Trager, William F ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; COUMARIN; CYTOCHROME P450; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; DIETHYLDITHIOCARBAMIC ACID; DRUG METABOLITE; FURAFYLLINE; QUININE SULFATE; SULFAPHENAZOLE; SULFINPYRAZONE; SULFINPYRAZONE SULFIDE; SULFINPYRAZONE SULFONE; TROLEANDOMYCIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG OXIDATION; DRUG STRUCTURE; ENANTIOMER; HEAT TREATMENT; HUMAN; HUMAN CELL; LIVER MICROSOME; PH; PRIORITY JOURNAL;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; HUMANS; MICROSOMES, LIVER; OXIDATION-REDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFINPYRAZONE;

CINCHONA PUBESCENS;

EID: 0035039708     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Potentiation of warfarin action by sulfinpyrazone
2. Species differences in the disposition and metabolism of sulfinpyrazone
3. New metabolites of sulfinpyrazone in man
4. Biotransformation and pharmacokinetics of sulfinpyrazone (Anturan) in man
5. Role of human cytochrome P450 IIE1 in the oxidation of many low molecular weight cancer suspects
6. Oxidation of quinidine by human liver cytochrome P-450
7. Allelic variants of human cytochrome P450 2C9: Baculovirus-mediated expression, purification, structural characterization, substrate stereoseloctivity, and prochiral selectivity of the wild-type and mutant forms
8. Inhibition of phenytoin metabolism by sulfinpyrazone
9. Inhibition of (S)-warfarin metabolism by sulfinpyrazone and its metabolites
10. Intrinsic isotope effects suggest that the reaction coordinate symmetry for the cytochrome P-450 catalyzed hydroxylation of octane is isozyme independent
11. Size limits of thiocarbamides accepted as substrates by human flavin-containing monooxygenase 1
12. Cyclooxygenase inhibition, platelet function, and metabolite formation during chronic sulfinpyrazone dosing
13. Sulfinpyrazone metabolism during long-term therapy
14. Simultaneous determination of sulfinpyrazone and four of its metabolites by high-performance liquid chromatography
15. Clinical pharmacokinetics and potentially important drug interactions of sulfinpyrazone
16. Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline
17. Pharmacokinetics and reversible biotransformation of sulfinpyrazone and its metabolites in rabbits. I. Single-dose study. II. Multiple-dose study
18. Interaction of sulfinpyrazone with warfarin
19. The effect of sulfinpyrazone on oxidative drug metabolism in man: Inhibition of tolbutamide elimination
20. Tolbutamide hydroxylation by human liver microsomes: Kinetic characterization and relationship to other cytochrome P-450 dependent xenobiotic oxidations
21. Uber derivate und analoge des phenylbutazons IV. Analog mit schwefelhaltigen seitenketten
22. Sulphoxides and sulphones
23. The role of the gut flora in the reduction of sulfinpyrazone in the rat
24. Characteristics of warfarin hydroxylation catalyzed by human liver microsomes
25. Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: A role for P-4502C9 in the etiology of (S)-warfarin-drug interactions
26. Plasma levels of sulfinpyrazone and two of its metabolites after a single dose and during the steady state
27. Stereoselective sulfoxidation by human flavin-containing monooxygenase. Evidence for catalytic diversity between hepatic, renal, and fetal forms
28. Furafylline is a potent and selective inhibitor of cytochrome P450 1A2 in man
29. Role of the gut flora in the reduction of sulfinpyrazone in humans
30. The warfarin-sulfinpyrazone interaction: Stereochemical considerations
31. Identification of an inducible form of cytochrome P-450 in human liver
32. Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s
33. Microsomal ravin-containing monooxygenase: Oxygenation of nucleophilic nitrogen and sulfur compounds