Induction of T helper cell type 1 response and elimination of HBeAg during treatment with IL-12 in a patient with therapy-refractory chronic hepatitis B

Hepato-Gastroenterology

Volumn 48, Issue 38, 2001, Pages 553-555

  Barth, H ^a   Klein, R ^a   Berg, P A ^a   Wiedenmann, B ^a   Hopf, U ^a   Berg, T ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Chronic hepatitis B; IL 12 therapy; Peripheral blood mononuclear cells; TH1 TH2 cytokines

Indexed keywords

FAMCICLOVIR; HEPATITIS B(E) ANTIGEN; INTERLEUKIN 12;

ADULT; ARTICLE; CASE REPORT; CHRONIC HEPATITIS; DOSE RESPONSE; DRUG EFFECT; DRUG ELIMINATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HELPER CELL; HEPATITIS B; HUMAN; IMMUNOREGULATION; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; SEROCONVERSION; T LYMPHOCYTE ACTIVATION;

ADJUVANTS, IMMUNOLOGIC; ADULT; ALANINE TRANSAMINASE; DNA, VIRAL; HEPATITIS B E ANTIGENS; HEPATITIS B, CHRONIC; HUMANS; INTERFERON-ALPHA; INTERLEUKIN-12; MALE; T-LYMPHOCYTES; TREATMENT FAILURE;

EID: 0035038584     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. To kill or to cure: Options in host defense against viral infection
2. Interleukin-12 inhibits hepatitis B virus replication in transgenic mice
3. A phase I/II study of recombinant human interleukin-12 in patients with chronic hepatitis B
4. A pretransplant infection with precore mutants of hepatitis B virus does not influence the outcome of orthotopic liver transplantation in patients on high dose anti-hepatitis B virus surface antigen immunoprophylaxis
5. Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes
6. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes
7. The expanding universe of T-cell subsets: TH1, TH2 and more
8. Cytotoxic T cells and viral hepatitis
9. Verstärkung einer TH1-Antwort durch IL-12 korreliert mit einer Verminderung der Viruslast: Preliminare Ergebnisse bei 15 Patienten mit therapierefraktärer chronischer B- und C-Hepatitis
10. Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals