The dead core model applied to beads with immobilized cells in a fed-batch cephalosporin C production bioprocess

Chemical Engineering Science

Volumn 56, Issue 2, 2001, Pages 419-425

  Cruz, A J G ^a   Almeida, R M R G ^a   Araujo, M L G C ^b   Giordano, R C ^a   Hokka, C O ^a  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

lactam; Cephalosporin C; Cephalosporium; Dead core model; Fed batch

Indexed keywords

BIOPROCESS; CELL GROWTH; CEPHALOSPORIN C; DISSOLVED OXYGEN; FED BATCH CULTURE; IMMOBILIZED CELL; MASS TRANSFER; MODEL; OXYGEN TRANSFER; SCANNING ELECTRON MICROSCOPY; SIMULATION;

BIOREACTORS; CELL CULTURE; FERMENTATION; FUNGI; MASS TRANSFER; OXYGEN; SCANNING ELECTRON MICROSCOPY; SUGARS;

BIOPROCESSES;

CELL IMMOBILIZATION;

BIOREACTOR;

EID: 0035028379     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2509(00)00244-X     Document Type: Article

References (11)

1. Comparative studies on cephalosporin C production process with free and immobilized cells of Cephalosporium acremonium ATCC 48272
2. Studies on the respiration rate of free and immobilized cells of Cephalosporium acremonium in cephalosporin C production
3. Further studies on carbon catabolite regulation of β-lactam antibiotic synthesis in Cephalosporium acremonium
4. Modeling and optimization of the cephalosporin C production bioprocess in a fed-batch bioreactor with invert sugar as substrate
5. Effect of methionine, norleucine, and lysine derivatives on cephalosporin C formation in chemically defined media
6. A new method using hexamethyldisilazane for preparation of soft insect tissues for scanning electron microscopy
7. A comparative evaluation of cephalosporin C production using various immobilization modes