Modelling and optimization of the cephalosporin C production bioprocess in a fed-batch bioreactor with invert sugar as substrate

Chemical Engineering Science

Volumn 54, Issue 15-16, 1999, Pages 3137-3142

  Cruz, A J G ^a   Silva, A S ^a   Araujo, M L G C ^b   Giordano, R C ^a   Hokka, C O ^a  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

lactam; Bioprocess optimization; Cephalosporin C; Cephalosporium acremonium; Fed batch; Invert sugar

Indexed keywords

BIOREACTOR; CARBON; CEPHALOSPORIN C; FED BATCH REACTOR; GLUCOSE; PROCESS MODEL; PROCESS OPTIMIZATION; SUGAR;

BIOREACTORS; GLUCOSE; MATHEMATICAL MODELS; MICROORGANISMS; OPTIMIZATION; SUGAR (SUCROSE);

BIOPROCESS OPTIMIZATION; CEPHALOSPORIN C; CEPHALOSPORIUM ACREMONIUM; FED BATCH; INVERT SUGAR;

ANTIBIOTICS;

ANTIBIOTIC AGENT; BIOREACTOR; MATHEMATICAL MODELING; OPTIMIZATION; PRODUCTION SYSTEM;

EID: 0033167273     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2509(98)00364-9     Document Type: Article

References (16)

1. Araujo, M.L.G.C., Oliveira, R.P., Giordano, R.C., & Hokka, C.O. (1996). Comparative studies on cephalosporin C production process with free and immobilized cells of Cephalosporium acremonium ATCC 48272. Chem. Engng Sci., 51(11), 2835-2840.
2. Bailey, J.E., & Ollis, D.F. (1986). Biochemical Engineering Fundamentals (2nd Ed). New York: McGraw-Hill.
3. Basak, S., Velayudhan, A., & Ladish, M.R. (1995). Simulation of diauxic production of cephalosporin C by Cephalosporium acremonium: Lag model for fed-batch fermentation. Biotechnol. Progr., 11, 626-631.
4. Claridge, C.A., & Johnson, D.L. (1962). A specific bio-assay for cephalosporin C in fermentation broths. Antimicrobial Agents Chemotherapy, 682-686.
5. Cruz, A.J.G., Araujo, M.L.G.C., Giordano, R.C., & Hokka, C.O. (1998). Phenomenological and neural-network modeling of cephalosporin C production bioprocess. Appl. Biochem. Biotechnol., 70-72, 579-592.
6. Chu, W.-B., & Constantinides, A. (1987). Modeling, optimization, and computer control of the cephalosporin C fermentation process. Biotechnol. Biong, 32, 277-288.
7. Demain, A.L., Newkirk, J.F., Hendlin, D. (1963). Effect of methionine, norleucine, and lysine derivatives on cephalosporin C formation in chemically defined media. J. Bacteriol., 8, 107-114.
8. Hosler, P. & Johnson, M.J. (1953). Penicillin from chemically defined media. Ind. Engng Chem., 45, 768-874.
9. Machado, J.R., Araujo, M.L.G.C., & Hokka, C.O. (1997). Estudo cinético da hidrólise da sacarose no processo de produção de cefalosporina C. Anais XIX Congresso Brasileiro de Microbiologia, Rio de Janeiro, RJ, Brasil (p. 200).
10. Marquardt, D.W. (1963). An algorithm for least-squares estimation of non-linear parameters. J. Soc. Ind. Appl. Math., 11, 431-441.
11. Matsumura, M., Imanaka, T., Yoshida, T., & Taguchi, H. (1981). Modeling of cephalosporin C production and its application to fed-batch culture, J. Fermentation Technol., 59(2), 115-123.
12. Petzold, L. (1989). Subroutine DDASSL, Computing and Mathematics Research Division, Lawrence Livermore National Laboratory, Livermore, CA.
13. Ribeiro, E.J. (1989). Estudo Cinético da Hidrólise de Sacarose por Invertase Livre e Imobilizada. FEA-UNICAMP, Ph.D. thesis, Campinas, SP, Brasil.
14. Shen, Y.-Q., Wolfe, S., & Demain, A.L. (1986). Levels of isopenicillin N synthetase and deacetoxycephalosporin C synthetase in Cephalosporium acremonium producing high and low levels of cephalosporin C. Bio-technol. 4, 61-64.
15. Soltero, F.V., & Johnson, M. (1953). The effect of the carbohydrate nutrition on penicillin production by Penicillium chrysogenum Q-176. Appl. Microbiol., 1, 52-56.
16. Vicik, S.M., Fedor, A.J. & Swartz, R.W. (1990). Defining an optimum carbon source/methionine feed strategy for growth and cephalosporin C formation by Cephalosporium acremonium. Biotechnol. Prog., 6(5), 333-340.