Gamma-vinyl GABA reduces paired pulse inhibition in the rat dentate gyrus in vivo and in vitro

Epilepsy Research

Volumn 44, Issue 2-3, 2001, Pages 109-117

  Sayin, Ümit ^a   Rutecki, Paul A ^a,b   Mellanby, Jane ^c   Sutula, Thomas P ^a,d  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b Neurosurg Neurosci Train P ^*  (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Dentate gyrus; GABA; GVG; Hippocampus; Inhibition; Vigabatrin

Indexed keywords

3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; PRESYNAPTIC RECEPTOR; SACLOFEN; VIGABATRIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENTATE GYRUS; EXCITATORY POSTSYNAPTIC POTENTIAL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STIMULUS RESPONSE;

ACTION POTENTIALS; ANIMALS; ANTICONVULSANTS; DENTATE GYRUS; GABA ANTAGONISTS; MALE; ORGANOPHOSPHORUS COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; VIGABATRIN;

EID: 0035023401     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(01)00200-5     Document Type: Article

References (39)

1. Ben-Menachem E. Vigabatrin. Epilepsia. 36:(suppl 2):1995;S95-S104.
2. Browne T.R., Mattson R.H., Napoliello M.J., Penry J.K., Smith O., Treiman O. Vigabatrin for refractory complex partial seizures: multi center single blind study with long term follow-up. Neurology. 37:1987;184-189.
3. Brucato F.H., Mott D.D., Lewis D.V., Swartzwelder H.S. GABAB receptors modulate synaptically-evoked responses in the rat dentate gyrus, in vivo. Brain Res. 677:1995;326-332.
4. B receptor activation in the dentate gyrus of rat. J. Neurosci. 11:1991;1198-1209.
5. Davies C.H., Davies S.N., Collingridge G.L. Paired pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus. J. Physiol. (Lond.). 424:1990;513-531.
6. Davies C.H., Collingridge G.L. The physiological regulation of synaptic inhibition by GABAB autoreceptors in rat hippocampus. J. Physiol. 472:1993;245-265.
7. de Bittencourt P.R., Mazer S., Marcourakis T., Bigarelle M.M., Ferreira Z.S., Mumford J. Vigabatrin: clinical evidence supporting rational pelotherapy in management of uncontrolled seizures. Epilepsia. 35:1994;373-380.
8. de Krom M.C., Verduin N., Visser E., Kleijer M., Scholtes F., De Groen J.H. Status epilepticus during vigabatrin treatment: a report of three cases. Seizure. 2:1995;159-162.
9. Halonen T., Miettinen R., Toppinen A., Tuunanen J., Kotti T., Riekkinen P.J. Vigabatrin protects against kainic acid-induced neuronal damage in the rat hippocampus. Neurosci. Lett. 95:1995;13-16.
10. Halonen T., Pitkannen A., Riekkinen P.J. Administration of vigabatrin affects the levels of inhibitory and excitatory amino acids in rat cerebrospinal fluid. J. Neurochem. 55:1990;1870-1873.
11. Hosford D.A., Wang Y. Utility of the lethargic (lh/lh) mouse model of absence seizures in predicting the effects of lamotrigine, vigabatrin, tiagabine, gabapentine, and tobiramate against human absence seizures. Epilepsia. 38:1997;408-414.
12. Iodorala M.J., Gale K. Substantia nigra: site of anticonvulsant activity mediated by GABA. Science. 218:1982;1237-1240.
13. Jackson F.M., Trevor D., Esplin B., Capek R. Acute effects of gamma-vinyl-GABA on hippocampal GABAergic inhibition in vitro. Brain Res. 651:1994;85-91.
14. Jawad S., Clarke E., Richens A. Vigabatrin-induced psychosis - management problems. Seizure. 3:1994;309-310.
15. Jolkkonen J., Mazukiewiecz M., Lahtinen H., Riekkinen P. Acute effects of gamma-vinyl GABA on the GABAergic system in rats as studied by microdialysis. Eur. J. Pharmacol. 229:1992;269-272.
16. Kalichman M.W., Burnham W.M., Livingstone K.E. Pharmacological investigation of GABA and fully developed generalized seizures in the amygdala kindled rat. Neuropharmacology. 21:1982;127-131.
17. Lortie A., Chiron C., Mumfurd J., Dulac O. The potential for increasing seizure frequency, relapse and appearance of new seizure types with vigabatrin. Neurology. 43:(S5):1993;S24-S27.
18. Loscher W. Effect of inhibitors of GABA transaminase on the synthesis, binding, uptake, and metabolism of GABA. J. Neurochem. 315:1980;119-128.
19. Loscher W., Honack D., Taylor C.P. Gabapentin increases amino-oxyacetic acid induced GABA accumulation in several regions of the brain. Neurosci. Lett. 128:1991;150-154.
20. Loscher W. New visions in the pharmacology of anticonvulsion. Eur. J. Pharmacol. 342:1998;1-13.
21. Luna D., Dulac O., Pajot N., Beaumont D. Vigabatrin in the treatment of childhood epilepsies: a single-blind placebo-controlled study. Epilepsia. 30:1989;430-437.
22. McKee P.J., Blacklaw J., Friel E., Thompson G.G., Gillham R.A., Brodie M.J. Adjuvant vigabatrin in refractory epilepsy: a ceiling to effective dosage in individual patients? Epilepsia. 34:1993;937-943.
23. Miller J.W., McKeon A.C., Ferrendelli J.A. Functional anatomy of pentylenetetrazol and electroshock seizures in the rat brainstem. Ann. Neurol. 22:1987;615-621.
24. Mott D.D., Bragdon A.C., Lewis D.V., Wilson W.A. Baclofen has a proepileptic effect in the rat dentate gyrus. J. Pharmacol. Exp. Ther. 249:1987;721-725.
25. Mott D.D., Xie C., Wilson A.W., Swartzwelder H.S., Lewis D.V. GABAB autoreceptors mediate activity-dependent disinhibition and enhance signal transmission in the dentate gyrus. J. Neurophysiol. 69:1993;674-691.
26. Mott D.D., Lewis D.V. The pharmacology and function of central GABAB receptors. Int. Rev. Neurobiol. 36:1994;97-223.
27. Oliver M.N., Miller J.J. Alteration of inhibitory processes in the dentate gyrus following kindling-induced epilepsy. Exp. Brain Res. 57:1985;443-447.
28. Olsen, R.W., Avoli, M., 1997. GABA and Epileptogenesis. Epilepsia 38, 399-407.
29. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1982;Academic Press, NY.
30. Perucca E. The clinical pharmacology of the new antiepileptic drugs. Pharmacol. Res. 28:1993;89-106.
31. Perucca E., Gram L., Avanzini G., Dulac O. Antiepileptic drugs as a cause of worsening seizures. Epilepsia. 39:1998;5-17.
32. Petroff O.A.J., Rothman D.L. Measuring human brain GABA in vivo. Molec. Neurobiol. 16:1998;97-121.
33. Petroff O.A.C., Rothman D.L., Behar K.L., Collins B.A., Mattson R.H. Human brain GABA levels rise rapidly after initiation of vigabatrin therapy. Neurology. 47:1996;1567-1571.
34. Reynolds E.G., Ring H., Heller A. A controlled trial of gamma vinyl GABA in drug resistant epilepsy. Br. J. Clin. Pharmacol. 33:1988;937-946.
35. Rich-Bennet E., Dahl D., Lecompte B.B. Modulation of paired pulse activation in the hippocampal dentate gyrus by cholecystokinin, baclofen and bicuculline. Neuropeptides. 24:1993;263-270.
36. Sayin Ü., Timmerman W., Westerink B.H.C. The significance of extracellular GABA in the substantia nigra of the rat during seizures and anticonvulsant treatments. Brain Res. 669:1995;67-72.
37. Sayin Ü., Cengiz S., Altug T. Vigabatrin as an anticonvulsant against pentylenetetrazol seizures. Pharmacol. Res. 28:1993;325-331.
38. Stevens J., Philips I., Beuropaire R. Gamma vinyl GABA in endopiriform area suppresses kindled amygdala seizures. Epilepsia. 29:1988;404-411.
39. Xiong Z., Stringer J.L. Effects of felbamate, gabapentin, and lamotrigine on seizure parameters and excitability in the rat hippocampus. Epilepsy Res. 27:1997;187-194.