A sensitive transgenic plant system to detect toxic inorganic compounds in the environment

Nature Biotechnology

Volumn 19, Issue 6, 2001, Pages 568-572

  Kovalchuk, Olga ^a   Titov, Victor ^b   Hohn, Barbara ^a   Kovalchuk, Igor ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b IVANO FRANKIVSK NATIONAL MEDICAL UNIVERSITY   (Ukraine)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIOMARKERS; GENES; GENETIC ENGINEERING; MUTAGENESIS; SOIL POLLUTION; TOXICITY;

TRANSGENIC PLANT;

BIOTECHNOLOGY;

ARSENIC; BETA GLUCURONIDASE; CADMIUM; COPPER; HEAVY METAL; LEAD; NICKEL; ZINC;

ARABIDOPSIS; ARTICLE; CHROMOSOME REARRANGEMENT; CONTAMINATION; ENVIRONMENTAL MONITORING; GENOTOXICITY; MARKER GENE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SOIL; TRANSGENIC PLANT;

ANIMALS; ARABIDOPSIS; ARSENIC; CADMIUM; CELLS, CULTURED; COPPER; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENT; GLUCURONIDASE; LEAD; METALS, HEAVY; MODELS, GENETIC; MUTAGENS; NICKEL; PLANTS, GENETICALLY MODIFIED; POINT MUTATION; RECOMBINATION, GENETIC; SOIL; ZINC;

ARABIDOPSIS; ARABIDOPSIS THALIANA; EMBRYOPHYTA;

EID: 0035021565     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/89327     Document Type: Article

References (35)

1. Metal-regulated transcription in eukaryotes
2. Copper metabolism in Menke's disease
3. Detection of genotoxic effects of heavy metal contaminated soils with plant bioassays
4. Current aspects in metal genotoxicity
5. Spontaneous mutation in the Escherichia coli lacl gene
6. Classifying mutagens as to their specificity in causing the six possible transitions and transversions: A simple analysis using the Salmonella mutagenicity assay
7. Performance of 133 compounds in the lambda prophage induction endpoint of the Microscreen assay and a comparison with S. typhimurium mutagenicity and rodent carcinogenicity assays
8. Comparative investigations of the genotoxic effects of metals in the single cell gell (SCG) assay and the sister chromatid exchange (SCE) test
9. Sister chromatid exchanges after exposure to metal-containing emissions
10. Mutagenic effects of some water-soluble metal compounds in a somatic eye-color test system in Drosophila melanogaster
11. A transgenic mouse model for the detection of cellular stress induced by toxic inorganic compounds
12. Nickel subsulfide is genotoxic in vitro but shows no mutagenic potential in respiratory tract tissues of BigBlue rats and Muta Mouse mice in vivo after inhalation
13. Metal mutagenesis
14. Genotoxic effects of heavy metals: Comparative investigation with plant bioassays
15. Higher plant assays for the detection of chromosomal aberrations and gene mutations-a brief historical background on their use for screening and monitoring environmental chemicals
16. The Allium test - An alternative in environmental studies: The relative toxicity of metal ions
17. Induction of homologous DNA recombination in whole plants
18. Transgenic plants are sensitive bioindicators of nuclear pollution caused by the Chernobyl accident
19. Genome-wide variation of the somatic mutation frequency in transgenic plants
20. Intrachromosomal homologous recombination in whole plants
21. Intrachromosomal recombination in plants
22. Arabidopsis thaliana mutants altered in homologous recombination
23. DNA damage and oxygen radical toxicity
24. Effects of nickel on DNA methyltransferase activity levels and genomic DNA methylation
25. Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: A model for a mechanism of carcinogenesis
26. Evaluation of the Allium cepa anaphase-telophase test in relation to genotoxicity screening of industrial wastewater
27. Bacterial and enzymatic bioassays for toxicity testing in the environment
28. Evaluation of a microplate assay specific for heavy metal toxicity
29. A comparison of microbial bioassays for the detection of metal toxicity
30. Arsenic [III] and heavy metal ions induce intrachromosomal homologous recombination in the hprt gene of V 79 Chinese hamster cells
31. Heavy metal toxicity testing in environmental samples
32. The use of the Escherichia coli betaglucuronidase as a gene fusion marker for studies of gene expression in higher plants