Progesterone and testosterone in combination act in the hypothalamus of castrated rams to regulate the secretion of LH

Journal of Endocrinology

Volumn 169, Issue 2, 2001, Pages 291-298

  Turner, A I ^a   Tilbrook, A J ^a   Clarke, I J ^b   Scott, C J ^a  

^a MONASH UNIVERSITY   (Australia)

^b HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG VEHICLE; GESTAGEN; GONADORELIN; LUTEINIZING HORMONE; MESSENGER RNA; PROGESTERONE; PROGESTERONE RECEPTOR; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BLOOD SAMPLING; BRAIN; CASTRATION; CONTROLLED STUDY; DRUG ACTIVITY; GONAD; HORMONAL REGULATION; HORMONE INHIBITION; HYPOTHALAMUS; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; HYPOTHESIS; IN SITU HYBRIDIZATION; LUTEINIZING HORMONE RELEASE; MALE; NEGATIVE FEEDBACK; NERVE CELL; NONHUMAN; PREOPTIC AREA; PRIORITY JOURNAL; SHEEP; STRIA TERMINALIS;

ANALYSIS OF VARIANCE; ANIMALS; AUTORADIOGRAPHY; DEPRESSION, CHEMICAL; FEEDBACK; HYPOTHALAMUS; IN SITU HYBRIDIZATION; LUTEINIZING HORMONE; MALE; ORCHIECTOMY; PROGESTERONE; RECEPTORS, PROGESTERONE; RNA, MESSENGER; SECRETORY RATE; SHEEP; TESTOSTERONE;

EID: 0035020591     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1690291     Document Type: Article

References (36)

1. Bebb RA, Anawalt BD, Christensen RB, Paulsen CA, Bremner WJ & Matsumoto AM 1996 Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: a promising male contraceptive approach. Journal of Clinical Endocrinology and Metabolism 81 757-762.
2. Blaustein JD, Ryer HI & Feder HH 1980 A sex difference in the progestin receptor system of guinea pig brain. Neuroendocrinology 31 403-409.
3. Bolt DJ 1971 Changes in the concentration of luteinizing hormone in plasma of rains following administration of oestradiol, progesterone or testosterone. Journal of Reproduction and Fertility 24 435-438.
4. Bremner WJ, Cumming IA, Winfield CG, de Kretser DM & Galloway DB 1984 A study of the reproductive performance of mature Romney and Merino rams throughout the year. In Reproduction in Sheep, vol 1 pp 16-17. Eds DR Lindsay & DT Pearce. Canberra: Australian Academy of Science and Australian Wool Corporation.
5. Brown TJ, Clark AS & MacLusky NJ 1987 Regional sex differences in progestin receptor induction in the rat hypothalamus: effects of various doses of estradiol benzoate. Journal of Neuroscience 7 2529-2536.
6. Brown TJ, Yu J, Gagnon M, Sharma M & MacLusky NJ 1996 Sex differences in estrogen receptor and progestin receptor induction in the guinea pig hypothalamus and preoptic area. Brain Research 725 37-48.
7. Carr BR 1997 Re-evaluation of oral contraceptive classifications. International Journal of Fertility and Menopausal Studies 42 133-144.
8. Clarke IJ & Cummins JT 1982 The temporal relationship between gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) secretion in ovariectomized ewes. Endocrinology 111 1737-1739.
9. Collins DC 1994 Sex hormone receptor binding, progestin selectivity, and the new oral contraceptives. American Journal of Obstetrics and Gynecology 170 1508-1513.
10. Dufourny L & Warembourg M 1996 Colocalization of progesterone receptor and somatostatic immunoreactivities in the hypothalamus of the male and female guinea pig. Neuroendocrinology 64 215-224.
11. Dufourny L, Warembourg M & Jolivet A 1997 Sex differences in estradiol-induced progestin receptor immunoreactivity in the guinea pig preoptic area and hypothalamus. Neuroscience Letters 223 109-112.
12. Echternkamp SE & Lunstra DD 1984 Relationship between LH and testicular development in progesterone-implanted prepubertal ram lambs. Journal of Animal Science 59 441-453.
13. Edgerton LA & Baile CA 1977 Serum LH suppression by estradiol but not by testosterone or progesterone in wethers. Journal of Animal Science 44 78-83.
14. Etgen AM 1981 Estrogen induction of progestin receptors in the hypothalamus of male and female rats which differ in their ability to exhibit cyclic gonadotropin secretion and female sexual behavior. Biology of Reproduction 25 307-313.
15. Geschwind H & Dewey R 1968 Dynamics of luteinizing hormone (LH) secretion in the cycling ewe: a radioimmunoassay study. Proceedings of the Society for Experimental Biology and Medicine 129 451-455.
16. Handelsman DJ, Conway AJ, Howe CJ, Turner L & Mackey MA 1996 Establishing the minimum effective dose and additive effects of depot progestin in suppression of human spermatogenesis by a testosterone depot. Journal of Clinical Endocrinology and Metabolism 81 4113-4121.
17. Hileman SM & Jackson GL 1999 Regulation of gonadotrophin-releasing hormone secretion by testosterone in male sheep. Journal of Reproduction and Fertility. Supplement 54 231-242.
18. Ing NH, Spencer TE & Bazer FW 1996 Estrogen enhances endometrial estrogen receptor gene expression by a posttranscriptional mechanism in the ovariectomized ewe. Biology of Reproduction 54 591-599.
19. Jackson GL, Kuehl D & Rhim TJ 1991 Testosterone inhibits gonadotropin-releasing hormone pulse frequency in the male sheep. Biology of Reproduction 45 188-194.
20. Karsch FJ, Cummings JT, Thomas GB & Clarke IJ 1987 Steroid feedback inhibition of pulsatile secretion of gonadotropin-releasing hormone in the ewe. Biology of Reproduction 36 1207-1218.
21. Lauber AH, Romano GJ & Pfaff DW 1991 Gene expression for estrogen and progesterone receptor mRNAs in rat brain and possible relations to sexually dimorphic functions. Journal of Steroid Biochemistry and Molecular Biology 40 53-62.
22. Lee VW, Cumming IA, de Kretser DM, Findlay JK, Hudson B & Keogh EJ 1976 Regulation of gonadotrophin secretion in rams from birth to sexual maturity. I. Plasma LH, FSH and testosterone levels. Journal of Reproduction and Fertility 46 1-6.
23. Lubbers LS & Jackson GL 1993 Neuroendocrine mechanisms that control seasonal changes of luteinizing hormone secretion in sheep are sexually differentiated. Biology of Reproduction 49 1369-1376.
24. Meriggiola MC & Bremner WJ 1997 Progestin-androgen combination regimens for male contraception. Journal of Andrology 18 240-244.
25. Meriggiola MC, Bremner WJ, Costantino A, Di Cintio G & Flamigni C 1998 Low dose of cyproterone acetate and testosterone enanthate for contraception in men. Human Reproduction 13 1225-1229.
26. Olster DH & Blaustein JD 1990 Immunocytochemical colocalization of progestin receptors and beta-endorphin or enkephalin in the hypothalamus of female guinea pigs. Journal of Neurobiology 21 768-780.
27. Ryer HI & Feder HH 1984 Development of steroid-receptor systems in guinea pig brain. III. Nuclear progestin receptors. Developmental Brain Research 13 23-27.
28. Sakurai H, Adams BM & Adams TE 1997 Concentration of GnRH receptor and GnRH receptor mRNA in pituitary tissue of orchidectomized sheep: effect of oestradiol, progesterone, and progesterone withdrawal. Journal of Endocrinology 152 91-98.
29. Schneider JS, Sleiter NC & Levine JE 1999 Endocrine abnormalities in male mice carrying a null mutation for the progesterone receptor gene. Proceedings of the Endocrine Society 81 P2-17.
30. Scott CJ, Pereira AM, Rawson JA, Simmons DM, Rossmanith WG, Ing NH & Clarke IJ 2000 The distribution of progesterone receptor (PR) immunoreactivity (-ir) and mRNA in the preoptic area and hypothalamus of the ewe; up-regulation of PR mRNA in the mediobasal hypothalamus by estrogen. Journal of Neuroendocrinology 12 565-575.
31. Simmons DM, Arriza JL & Swanson LW 1989 A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radio-labeled single-stranded RNA probes. Journal of Histotechnology 12 169-181.
32. Tilbrook AJ & Clarke IJ 1995 Negative feedback regulation of the secretion and actions of GnRH in male ruminants. Journal of Reproduction and Fertility. Supplement 49 297-306.
33. Tilbrook AJ, de Kretser DM, Cummins JT & Clarke IJ 1991 The negative feedback effects of testicular steroids are predominantly at the hypothalamus in the ram. Endocrinology 129 3080-3092.
34. Tilbrook AJ, de Kretser DM & Clarke IJ 1999 Seasonal changes in the negative feedback regulation of the secretion of the gonadotrophins by testosterone and inhibin in rams. Journal of Endocrinology 160 155-167.
35. Van Lier R, Regueiro M, Perez-Clariget R, Andersson H, Kindahl H & Forsberg M 1999 Effects of adrenocorticotrophin (ACTH) and progesterone on luteinising hormone (LH) secretion in recently castrated rams. Animal Reproduction Science 55 115-126.
36. Wu FCW, Balasubramanian R, Mulders TMT & Coelingh-Bennink HJT 1999 Oral progestogen combined with testosterone as a potential male contraceptive: additive effects between desogestrel and testosterone enanthate in suppression of spermatogenesis, pituitary-testicular axis, and lipid metabolism. Journal of Clinical Endocrinology and Metabolism 84 112-122.