Central muscarinic mechanisms regulating voiding in rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 297, Issue 3, 2001, Pages 933-939

  Ishiura, Yoshiyuki ^a,b   Yoshiyama, Mitsuharu ^a   Yokoyama, Osamu ^a,b   Namiki, Mikio ^b   De Groat, William C ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; OXOTREMORINE;

ANIMAL EXPERIMENT; ARTICLE; BLADDER CAPACITY; BLADDER CONTRACTION; BLADDER PRESSURE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; MICTURITION; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; URODYNAMICS;

ANIMALS; ATROPINE; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INJECTIONS, INTRAVENOUS; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SPINAL; MANOMETRY; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; OXOTREMORINE; RATS; RECEPTORS, MUSCARINIC; SPINAL CORD; URINARY BLADDER; URINATION;

EID: 0035019325     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Aagaard PJ and McKinney M (1993) Pharmacological characterization of the novel cholinomimetic L-689,660 at cloned and native brain muscarinic receptors. J Pharmacol Exp Ther 267:1478-1483.
2. Bartolini A, Ghelardini C, Fantetti L, Malcangio M, Malmherg AP and Giotti A (1992) Role of muscarinic receptor subtypes in central antinociception. Br J Pharmacol 105:77-82.
3. Brezenoff HE, Xiao YF and Vargas H (1988) A comparison of the central and peripheral antimuscarinic effects of atropine and methylatropine injected systemically and into the central ventricles. Life Sci 42:905-911.
4. Chapple CR (2000) Muscarinic receptor antagonists in the treatment of overactive bladder. Urology 55 (Suppl 5A):33-46.
5. Feldberg W and Fleischhauer K (1960) Penetration of bromophenol blue from the perfused cerebral ventricles into the brain tissue. J Physiol (Lond) 150:451-462.
6. Ishiura Y, Yokoyama O, Namiki M, Chancellor MB and de Groat WC (1999) Central muscarinic mechanisms regulating voiding in rats. Neurourol Urodyn 18:351-352.
7. Iwamoto ET and Marion L (1993) Characterization of the antinociception produced by intrathecally administered muscarinic agonists in the rat. J Pharmacol Exp Ther 266:329-338.
8. Li M, Yasuda RP, Wall SJ, Wellstein A and Wolfe BB (1991) Distribution of m2 muscarinic receptors in rat brain using antisera selective for m2 receptors. Mol Pharmacol 40:28-35.
9. Matsuzaki A (1990) A study of the pontine micturition urine storage center in decerebrate cats. Nippon Hinyokika Gakkai Zasshi 81:672-679.
10. McKinney M, Miller JH and Aagaard PJ (1993) Pharmacological characterization of the rat hippocampal muscarinic autoreceptor. J Pharmacol Exp Ther 264:74-78.
11. O'Donnell PD (1990) Central actions of bethanechol on the urinary bladder in dogs. J Urol 143:634-637.
12. Roppolo JR, Noto H, Mallory BS and de Groat WC (1987) Dopaminergic and cholinergic modulation of bladder reflexes at the level of the pontine micturition center in the cat. Abstr Soc Neurosci 13:733.
13. Sanchez C and Meier E (1993) Central and peripheral mediation of hypothermia, tremor and salivation induced by muscarinic agonists in mice. Pharmacol Toxicol 72:262-267.
14. Sillen U, Rubenson A and Hjalmas K (1982) Central cholinergic mechanisms in L-DOPA induced hyperactive urinary bladder of the rat. Urol Res 10:239-243.
15. Sugaya K, Matsuyama K, Takakusaki K and Mori T (1987) Electrical and chemical stimulations of the pontine micturition center. Neurosci Lett 80:197-201.
16. Thor KB, Muhlhauser MA, Sauerberg P, Shannon H and Springer JP (2000) Central muscarinic inhibition of lower urinary tract nociception. Brain Res 870:126-134.
17. Yaksh TL and Rudy TA (1976) Chronic catheterization of the spinal subarachnoid space. Physiol Behav 17:1031-1036.
18. Yaksh TL, Dirksen R and Harty GJ (1985) Antinociceptive effects of injected cholinominetic drugs in the rat and cat. Eur J Pharmacol 117:81-88.
19. Yaksh TL, Durant PA and Brent CR (1986) Micturition in rats: a chronic model for study of bladder function and effect of anesthetics. Am J Physiol 251:R1177-R1185.
20. Yoshiyama M, Nezu FM, Yokoyama O, Chancellor MB and de Groat WC (1999) Influence of glutamate receptor antagonists on micturition in rats with spinal cord injury. Exp Neurol 159:250-257.
21. Yoshiyama M, de Groat WC and Fraser MO (2000) Influences of external urethral sphincter relaxation induced by alpha-bungarotoxin, a neuromuscular junction blocking agent, on voiding dysfunction in the rat with spinal cord injury. Urology 55:956-960.
22. Zhou M and Gebhart GF (1991) Tonic cholinergic inhibition of spinal mechanical transmission. Pain 46:211-222.