Central muscarinic inhibition of lower urinary tract nociception

Brain Research

Volumn 870, Issue 1-2, 2000, Pages 126-134

  Thor, Karl B ^a,b   Muhlhauser, Mark A ^c   Sauerberg, Per ^d   Shannon, Harlan ^c   Springer, Johannes P ^e  

^a GenuPro Incorporated   (United States)

^b Department of Surgery   (United States)

^c ELI LILLY AND COMPANY   (United States)

^d NOVO NORDISK A S   (Denmark)

^e UNIVERSITY OF BERN   (Switzerland)

Author keywords

Acetylcholine; Bladder; Lower urinary tract; Muscarinic; Nociception; Vesicoanal

Indexed keywords

ATROPINE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR BLOCKING AGENT; NEOSTIGMINE; OXOTREMORINE; PHYSOSTIGMINE; SCOPOLAMINE METHYL BROMIDE;

ANIMAL EXPERIMENT; ARTICLE; BLADDER; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; ELECTROMYOGRAM; FEMALE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCHOLINE; ACTION POTENTIALS; ANIMALS; ATROPINE; CHOLINERGIC AGENTS; CHOLINESTERASE INHIBITORS; ELECTROMYOGRAPHY; FEMALE; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; MUSCLE, SMOOTH; NEOSTIGMINE; NOCICEPTORS; OXOTREMORINE; PAIN; PHYSOSTIGMINE; RATS; RATS, SPRAGUE-DAWLEY; REFLEX; THIADIAZOLES; URINARY BLADDER; VASODILATOR AGENTS;

EID: 0034617460     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02412-4     Document Type: Article

References (19)

1. Andersson K., Hedlund H. Basic and clinical aspects of cholinergic agents in bladder dysfunction. Prog. Brain Res. 84:1990;201-207.
2. Bartolini A., Ghelardini C., Fantetti L., Malcangio M., Malberg A.P., Giotti A. Role of muscarinic receptor subtypes in central antinociception. Br. J. Pharmacol. 105:1992;77-82.
3. Battacharya S.K., Sen A.P. Effects of muscarinic receptor agonists and antagonists on rat brain serotonergic activity. J. Neural Transm. 90:1992;241-247.
4. Craggs M.D., Rushton D.N., Stephenson J.A. A putative non-cholinergic mechanism in urinary bladders of new but not old world primates. J. Urol. 136:1986;1348-1350.
5. Gilman A.G., Rall T.W., Nies A.S., Tayley P. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 1990;Pergamon Press, Elmsford, NY.
6. Hartig P., Gillberg P., Gordh T., Post C. Cholinergic mechanisms in pain and analgesia. Trends Pharmacol. Sci. 1:(Suppl.):1989;75-79.
7. Iwamoto E.T., Marion L. Characterization of the antinociception produced by intrathecally administered muscarinic agonist in the rat. J. Pharmacol. Exp. Ther. 266:1993;329-338.
8. Muhlhauser M.A., Thor K.B. Chemical irritation or mechanical distension of the urethra elicits ano-excitatory and vesico-inhibitory reflexes in the urethane anesthetized rat. Soc. Neurosci. Abstr. 21:1995;734.12.
9. Roppolo J., Booth A., deGroat W. The effects of naloxone on the neural control of the urinary bladder of the cat. Brain Res. 264:1983;355-358.
10. Sauerberg P., Olesen P., Sheardown M., Suzdak P., Shannon H., Bymaster F., Calagaro D., Mitch C., Ward J., Swedberg M. Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity. SAR of alkylthio-TZTPs and related 1,2,5-thiadiaole analogs. Life Sci. 56:1995;807-814.
11. Shannon H., Sheardown M., Bymaster F., Calligaro D., DeLapp N., Gidda J., Mitch C., Sawyer B., Stengel P., Ward J., Wong D., Olesen P., Suzdak P., Sauerberg P., Swedberg M. Pharmacology of butylthiol[2.2.2] (LY297802/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity. J. Pharmacol. Exp. Ther. 281:1997;884-894.
12. Swedberg M., Sheardown M., Suaerberg M., Olesen P., Suzdak P., Hansen K., Bymaster F., Ward J., Mitch C., Calligaro D., DeLapp N., Shannon H. Butylthio[2.2.2] (NNC/11-1053/LY297802): An orally active muscarinic analgesic. J. Pharmacol. Exp. Ther. 281:1997;876-883.
13. Taylor J.E., Yaksh T.L., Richelson E. Agonist regulation of muscarinic acetylcholine receptors in rat spinal cord. J. Neurochem. 39:1982;521-524.
14. Terai T., Deguchi Y., Ohtsuka M., Kumada S. Effects of anti-cholinergic drug prifinium bromide on urinary bladder contractions in rat in vivo and in guinea pig in vitro. Drug Res. 41:1991;417-420.
15. Thor K., Muhlhauser M. Vesicoanal, urethroanal, and urethrovesical reflexes initiated by lower urinary tract irritation in the rat. Am. J. Physiol. 277:1999;R1002-R1012.
16. Thor K., Roppolo J., Kawatani M., Erdman S., deGroat W. Plasticity in spinal opioid control of lower urinary tract function in paraplegic cats. NeuroReport. 5:1994;1673-1678.
17. Yaksh T.L., Dirksen R., Harty G.J. Antinociceptive effects of intrathecally injected cholinomimetic drugs in the rat and cat. Eur. J. Pharmacol. 117:1985;81-88.
18. Zhou M., Gebhart G.F. Tonic cholinergic inhibition of spinal mechanical transmission. Pain. 46:1991;211-212.
19. Zhuo M., Gebhart G.F. Spinal cholinergic and monoaminergic receptors mediate descending inhibition from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. Brain Res. 535:1990;67-78.