Alternative splicing of amino-terminal tau mRNA in rat spinal cord during development and following axonal injury

Experimental Neurology

Volumn 169, Issue 1, 2001, Pages 105-113

  Halverson, Robyn A ^a   Chambers, Christopher B ^a,b   Muma, Nancy A ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b NORTHWESTERN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Abortive regeneration; Alzheimer's disease; Axotomy; Development; Nerve regeneration; Tau

Indexed keywords

TAU PROTEIN;

ALTERNATIVE RNA SPLICING; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXONAL INJURY; CONTROLLED STUDY; EXON; FEMALE; GENE OVEREXPRESSION; GENETIC CODE; MALE; NERVE FIBER TRANSECTION; NERVE GROWTH; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD;

EID: 0035014493     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2001.7637     Document Type: Article

References (49)

1. Relative exon affinities and suboptimal splice site signals lead to nonequivalence of two cassette exons
2. Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain
3. Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons
4. Overexpression of four-repeat tau mRNA isoforms in progressive supranuclear palsy but not in Alzheimer's disease
5. Tau mRNA isoforms following sciatic nerve axotomy with and without regeneration
6. Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17
7. Purification of tau a microtubule associated protein that induces assembly of microtubules from purified tubulin
8. Developmentally regulated alternative splicing of mRNAs encoding N-terminal tau variants in the rat hippocampus: Structural and functional implications
9. Axon sprouting in the rodent and Alzheimer's disease brain: A reactivation of developmental mechanisms
10. Regenerative failure: A potential mechanism for neuritic dystrophy in Alzheimer's disease
11. Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer's disease
12. Increased expression of the embryonic form of a developmentally regulated mRNA an Alzheimer's disease
13. Expression of separate isoforms of human tau protein: Correlation with the tau pattern in brain and effects on tubulin polymerization
14. Assembly of microtubuleassociated protein tau into Alzheimer-like filaments induced by sulfated glycosaminoglycans
15. Multiple isoforms of human microtubuleassociated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
16. Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: Differential expression of tau protein mRNAs in human brain
17. Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau
18. Involvement of mature tau isoforms in the stabilization of neurites in PC12 cells
19. FTDP-17 mutations N279K and S305N in tau pro duce increased splicing of exon 10
20. Structure of the bovine tau: Gene alternatively spliced transcripts generate a protein family
21. Microtubule organization and dynamics dependent on microtubule-associated proteins
22. Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: Induction of a specific beta tubulin isotype
23. Neurofilament gene expression: A major determinant of axonal caliber
24. Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17
25. Association of missense and 5′-splicesite mutations in tau with the inherited dementia FTDP-17
26. Microtubule bundling by tau proteins in vivo: Analysis of functional domains
27. Developmentally regulated expression of specific tau sequences
28. The histopathology of neuronal degeneration and plasticity in Alzheimer's disease
29. Differential expression of exons 10 and 11 in normal tau and tau associated with paired helical filaments
30. Non-motor microtubule-associated proteins
31. The microtubule binding domain of tau protein
32. Phosphorylation, calpain proteolysis and tubulin binding of recombinant human tau isoforms
33. Heterogeneity of tau proteins in Alzheimer's disease
34. Patterns of aberrant sprouting in Alzheimer's disease
35. Diversity of highmolecular-weight τ proteins in different regions of the nervous system
36. Isotypes of α-tubulin are differentially regulated during neuronal maturation
37. Rapid induction of the major embryonic α-tubulin mRNA, Tα1, during nerve regeneration in adult rats
38. Alterations in levels of mRNAs coding for neurofilament protein subunits during regeneration
39. Postnatal increases in neurofilament gene expression correlate with the radial growth axons
40. Indentification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2
41. Tau gene expression in rat sensory neurons during development and regeneration
42. Mitotic phosphorylation of tau protein in neuronal cell lines resembles phophorylation in Alzheimer's disease
43. Quantitative assessment of synaptic density in the entorhinal cortex in Alzheimer's disease
44. Differences in the abilities of human tau isoforms to promote microtubule assembly
45. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
46. The effect of axon injury on microtubule-associated protein MAP2 mRNA in the hypoglossal nucleus of the adult rat
47. Regulation of peripherin and neurofilament expression in regenerating rat motor neurons
48. A protein factor essential for microtubule assembly
49. Changes in the microtubule proteins in the developing and transected spinal cords of the bullfrog tadpone-induction of microtubule-associated protein 2C and enhanced levels of tau and tubulin in regenerating central axons