Mechanism of biochemical action of substituted benzopyran-2-ones. Part 8: Acetoxycoumarin: Protein transacetylase specificity for aromatic nuclear acetoxy groups in proximity to the oxygen heteroatom

Bioorganic and Medicinal Chemistry

Volumn 9, Issue 5, 2001, Pages 1085-1089

  Raj, Hanumantharao G ^a   Kohli, Ekta ^a   Goswami, Rajeev ^b   Goel, Sanjay ^a   Rastogi, Ramesh C ^b   Jain, Subhash C ^b   Wengel, Jesper ^c   Olsen, Carl E ^d   Parmar, Virinder S ^b  

^a UNIVERSITY OF DELHI   (India)

^b UNIVERSITY OF DELHI   (India)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

3 ACETOXYCOUMARIN; 4 ACETOXYCOUMARIN; 4 METHYLCOUMARIN DERIVATIVE; 5 ACETOXY 4 METHYLCOUMARIN; 5 ACETOXY 4,7 DIMETHYLCOUMARIN; 6 ACETOXY 4 METHYLCOUMARIN; 7 ACETOXY 4 METHYLCOUMARIN; 7,8 DIACETOXY 4 METHYLCOUMARIN; ACETOXYCOUMARIN PROTEIN TRANSACETYLASE; ACYLTRANSFERASE; AROMATIC COMPOUND; BENZOPYRAN 2 ONE DERIVATIVE; BENZOPYRAN DERIVATIVE; COUMARIN DERIVATIVE; FUNCTIONAL GROUP; GLUTATHIONE TRANSFERASE; OXYGEN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SPECIFICITY; LIVER MICROSOME; MALE; NONHUMAN; RAT;

AFLATOXIN B1; ANIMALS; BENZOPYRANS; COUMARINS; DNA; ENZYME ACTIVATION; GLUTATHIONE TRANSFERASE; MICROSOMES, LIVER; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXYGEN; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; UMBELLIFERONES;

EID: 0035014427     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00328-X     Document Type: Article

References (19)

1. Raj H.G., Gupta S., Biswas G., Singh S., Jha A., Bisht K.S., Sharma S.K., Jain S.C., Parmar V.S. Bioorg. Med. Chem. 4:1996;2225.
2. Raj H.G., Parmar V.S., Jain S.C., Goel S., Singh A., Gupta K., Rohil V., Tyagi Y.K., Jha H.N., Olsen C.E., Wengel J. Bioorg. Med. Chem. 6:1998;1895.
3. Malik, S. Studies on benzene-induced genotoxicity in bone marrow and lung cells M.D. (Medical Biochemistry) thesis submitted to the University of Delhi (1999).
4. Raj H.G., Parmar V.S., Jain S.C., Goel S., Singh A., Tyagi Y.K., Jha H.N., Olsen C.E., Wengel J. Bioorg. Med. Chem. 7:1999;369.
5. Pechmann H.V., Duisberg C. Chem. Ber. 16:1883;2119.
6. Parmar V.S., Bisht K.S., Jain R., Singh S., Sharma S.K., Gupta S., Malhotra S., Tyagi O.D., Vardhan A., Pati H.N. Indian J. Chem. 35B:1996;220.
7. Dixit V.M., Padukone V.U. J. Indian Chem. Soc. 27:1950;127.
8. Chakravarti D. J. Indian Chem. Soc. 8:1931;407.
9. Sen K., Bagchi P. J. Org. Chem. 24:1959;316.
10. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. J. Biol. Chem. 193:1951;265.
11. Raj H.G., Parmar V.S., Jain S.C., Kohli E., Ahmad N., Goel S., Tyagi Y.K., Sharma S.K., Wengel J., Olsen C.E. Bioorg. Med. Chem. 8:2000;1707.
12. Habig W.H., Pabst M.J., Jakoby W.B. J. Biol. Chem. 249:1974;7130.
13. Stewart J.J.P. J. Comput. Chem. 10:1989;209.
14. Stewart J.J.P. J. Comput. Chem. 10:1989;221.
15. Halpert J.R. Biochem. Pharmacol. 30:1981;875.
16. Lee T.-C., Uemura Y., Snyder F. J. Biol. Chem. 267:1992;19992.
17. Karasawa K., Qiu X., Lee T.-C. J. Biol. Chem. 274:1999;8655.
18. Bessman S.R., Lipmann T. Arch. Biochem. Biophys. 46:1953;252.
19. Wang T.V., Cerutti P.A. Cancer Res. 39:1979;5165.