Heteroplasmy of the human mtDNA control region remains constant during life

American Journal of Human Genetics

Volumn 68, Issue 5, 2001, Pages 1299-1301

  Lagerström Fermér, Maria ^a   Olsson, Charlotta ^a,b   Forsgren, Lars ^c   Syvänen, Ann Christine ^a  

^a Department of Medical Sciences ^*  (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ARTICLE; FEMALE; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; LONGITUDINAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE GENETICS; RETROSPECTIVE STUDY;

EID: 0035013624     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/320115     Document Type: Article

References (15)

1. Heteroplasmic point mutations in the human mtDNA control region
2. Length heteroplasmy in the first hypervariable segment of the human mtDNA control region
3. The frequency of heteroplasmy in the HVII region of mtDNA differs across tissue types and increases with age
4. Heteroplasmy in the control region of human mitochondrial DNA
5. Persistent heteroplasmy of a mutation in the human mtDNA control region: Hypermutation as an apparent consequence of simple-repeat expansion/contraction
6. Mitochondrial DNA sequence heteroplasmy in the Grand Duke of Russia Georgij Romanov establishes the authenticity of the remains of Tsar Nicholas II
7. Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA
8. Detection and quantitation of human papillomavirus by using the fluorescent 5′ exonuclease assay
9. Quantification of point mutations associated with Leber hereditary optic neuroretinopathy by solid-phase minisequencing
10. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
11. A high observed substitution rate in the human mitochondrial DNA control region
12. Quantification of tRNA3243(Leu) point mutation of mitochondrial DNA in MELAS patients and its effects on mitochondrial transcription
13. Identification of individuals by analysis of biallelic DNA markers, using PCR and solid-phase minisequencing
14. A sensitive denaturing gradient-gel electrophoresis assay reveals a high frequency of heteroplasmy in hypervariable region 1 of the human mtDNA control region
15. Mitochondrial diseases in man and mouse