Polymorphonuclear granulocytes induce myocardial dysfunction during ischemia and in later reperfusion of hearts exposed to low-flow ischemia

Journal of Leukocyte Biology

Volumn 69, Issue 5, 2001, Pages 727-731

  Seligmann, Christian ^a,b   Bock, Andreas ^a   Leitsch, Tobias ^a   Schimmer, Mike ^a   Simsek, Yusuf ^a   Schultheiss, Heinz Peter ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Contractile function; Guinea pig; Leukocytes; Oxygen free radicals

Indexed keywords

SCAVENGER; SUPEROXIDE DISMUTASE; THROMBIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; GUINEA PIG; HEART FUNCTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART PERFUSION; ISOLATED HEART; LYMPHOCYTE ACTIVATION; MALE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; REPERFUSION INJURY;

ANIMALS; CORONARY VESSELS; GUINEA PIGS; HEART; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NEUTROPHILS; SUPEROXIDE DISMUTASE;

EID: 0035011986     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Hansen, P. R. (1995) Role of neutrophils in myocardial ischemia and reperfusion. Circulation 91, 1872-1885.
2. Jordan, J. E., Zhao, Z. Q., Vinten-Johansen, J. (1999) The role of neutrophils in myocardial ischemia-reperfusion injury. Cardiovasc. Res. 43, 860-878.
3. Kilgore, K. S., Lucchesi, B. R. (2000) Neutrophils and altered myocardial function. Am. Heart J. 139, 32-34.
4. Park, J. L., Lucchesi, B. R. (1999) Mechanisms of myocardial reperfusion injury. Ann. Thorac. Surg. 68, 1905-1912.
5. Weiss, S. J. (1989) Tissue destruction by neutrophils. N. Engl. J. Med. 320, 365-376.
6. Bolli, R, Jeroudi, M. O., Patel, B. S. (1989) Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury. Circ. Res. 65, 607-622.
7. Boyle, E. M., Pohlmann, T. H., Cornejo, C. J., Verrier, E. D. (1996) Endothelial cell injury in cardiovascular surgery: ischemia-reperfusion. Ann. Thorac. Surg. 62, 1868-1875.
8. Korthuis, R. J., Anderson, D. C., Granger, D. N. (1994) Role of neutrophil-endothelial cell adhesion in inflammatory disorders. J. Crit. Care 9, 47-71.
9. Lefer, A. M., Ma, X. L., Weyrich, A., Lefer, D. J. (1993) Endothelial dysfunction and neutrophil adherence as critical events in the development of reperfusion injury. Agents Actions Suppl. 41, 127-135.
10. Simpson, P. J., Todd, R. F., Fantone, J. C., Mickelson, J. K., Griffin, J. D., Lucchesi, B. R. (1988) Reduction of experimental myocardial reperfusion injury by a monoclonal antibody (anti-Mol, anti-CD1lb) that inhibits leucocyte adhesion. J. Clin. Invest. 81, 624-629.
11. Heindl, B., Reichle, F. M., Zahler, S., Conzen, P. F., Becker, B. F. (1999) Sevoflurane and isoflurane protect the reperfused guinea pig heart by reducing postischemic adhesion of polymorphonuclear neutrophils. Anesthesiology 91, 521-530.
12. Dhalla, N. S., Adel, B. E., Tomoji, H., Naoki, M. (2000) Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc. Res. 47, 446-56.
13. Grech, E. D., Dodd, N. J., Jackson, M. J., Morrison, W. L., Faragher, E. B., Ramsdale, D. R. (1996) Evidence for free radical generation after primary percutaneous transluminal coronary angioplasty recanalization in acute myocardial infarction. Am. J. Cardiol. 77, 122-27.
14. Lefer, A. M., Lefer, D. J. (1998) Synergism between platelets and neutrophils in provoking cardiac dysfunction after ischemia and reperfusion. Circulation 98, 1322-1328.
15. Lefer, D. J., Scalia R., Campbell, B., Nossuli, T., Hayward, R., Salamon, M., Grayson, J., Lefer, A. M. (1997) Peroxynitrite inhibits leucocyte-endothelial cell-interactions and protects against ischemia-reperfusion injury in rats. J. Clin. Invest. 99, 684-691.
16. Jeroudi, M. O., Cheirif, J., Habib, G., Bolli, R. (1994) Prolonged wall motion abnormalities after chest pain at rest in patients with unstable angina: a possible manifestation of myocardial stunning. Am. Heart J. 127, 1241-1250.
17. Schwartz, L. M., Raschke, P., Becker, B. F., Gerlach, E. (1993) Adenosine contributes to neutrophil-mediated loss of myocardial function in post-ischemic guinea-pig hearts. J. Mol. Cell Cardiol. 25, 927-38.
18. Raschke, P., Becker, B. F., Leipert, B., Schwartz, L. M., Zahler, S., Gerlach, E. (1993) Postischemic dysfunction of the heart induced by small numbers of neutrophils via formation of hypochlorous acid. Bas. Res. Cardiol. 88, 311-39.
19. Moser, R., Groscurth, P., Fehr, J. (1990) Promotion of transendothelial neutrophil passage by human thrombin J. Cell. Sci. 96, 737-744.
20. Gulba, D. C., Westhoff-Bleck, M., Jost, S., Rafflenbeul, W., Daniel, W. G., Hecker, H., Lichtlen, P. R. (1991) Increased thrombin levels during thrombolytic therapy in acute myocardial infarction. Circulation 83, 937-944.
21. National Institutes of Health (1996) Guide for Care and Use of Laboratory Animals (NIH publication no. 85-23). National Institutes of Health, Washington, DC.
22. Bünger, R., Sommer, O., Walter, G., Stiegler, H., Gerlach, E. (1979) Functional and metabolic features of an isolated perfused guinea pig heart performing pressure-volume work. Pflüg. Arch. Eur. J. Physiol. 380, 259-266.
23. Zahler, S., Kupatt, C., Seligmann, C., Kowalski, C., Becker, B. F., Gerlach, E. (1997) Retention of leukocytes in reperfused, isolated hearts does not cause haemodynamically relevant permanent capillary plugging. Pfüg. Arch. Eur. J. Physiol. 433, 713-720.