Retention of leucocytes in reperfused, isolated hearts does not cause haemodynamically relevant permanent capillary plugging

Pflugers Archiv European Journal of Physiology

Volumn 433, Issue 6, 1997, Pages 713-720

  Zahler, S ^a   Kupatt, C ^a   Seligmann, C ^a   Kowalski, C ^a   Becker, B F ^a   Gerlach, E ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

CD18; Coronary resistance; Leucocyte adhesion; Microcirculation; Microspheres; Neutrophils; Reperfusion injury

Indexed keywords

CD18 ANTIGEN; MICROSPHERE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CORONARY ARTERY BLOOD FLOW; CORONARY VASCULAR RESISTANCE; GUINEA PIG; HEART MUSCLE ISCHEMIA; ISOLATED HEART; LEUKOCYTE ADHERENCE; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

ANIMALS; ANTIGENS, CD18; CAPILLARIES; CORONARY CIRCULATION; GUINEA PIGS; HUMANS; LEUKOCYTES; MALE; MICROSPHERES; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NEUTROPHILS; VASCULAR RESISTANCE;

EID: 0030891623     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240050336     Document Type: Article

References (32)

1. Bagge U, Blixt A, Strind KG (1983) The initiation of post-capillary margination of leukocytes: studies in vitro on the influence of erythrocyte concentration and flow velocity. Int J Microcirc Clin Exp 2: 215-227
2. Bassingthwaighte JB, Yipintsoi T, Harvey RB (1974) Microvasculature of the dog left ventricular myocardium. Microvasc Res 7: 229-249
3. Braide M, Amundson B, Chien S, Bagge U (1984) Quantitative studies on the influence of leukocytes on the vascular resistance in a skeletal muscle preparation. Microvasc Res 27: 331-352
4. Carlos TM, Harlan JM (1994) Leukocyte - endothelial adhesion molecules. Blood 84: 2068-2101
5. Engler RL, Schmid-Schönbein GW, Pavelec RS (1983) Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog. Am J Pathol 111: 98-111
6. Fenton BM, Wilson DW, Cokelet JR (1985) Analysis of the effects of measured white blood cell entrance times on hemodynamics in a computer model of a microvascular bed. Pflügers Arch 403: 396-401
7. Formigli L, Domenici-Lombardo L, Adembri C, Brunelleschi S, Ferrari E, Novelli GA (1992) Neutrophils as mediators of human skeletal muscle ischemia-reperfusion syndrome. Hum Pathol 23: 627-634
8. Granger DN, Benoit JN, Suzuki M, Grisham MB (1989) Leukocyte adherence to venular endothelium during ischemia-reperfusion. Am J Physiol 257: G683-G688
9. Hansell P, Borgström P, Arfors KE (1993) Pressure-related capillary leukostasis following ischemia-reperfusion and hemorrhagic shock. Am J Physiol 265: H381-H388
10. Harris AG, Skalak TC (1993) Leukocyte cytoskelelal structure determines capillary plugging and network resistance. Am J Physiol 265: H1670-H1675
11. House SD, Lipowsky HH (1987) Leukocyte-endothelium adhesion: microhemodynamics in mesentery of the cat. Microvasc Res 34: 363-379
12. Jerome SN, Dore M, Paulson JC, Smith CW, Korthuis RJ (1994) P-selectin and ICAM-1-dependent adherence reactions: role in the genesis of postischemic no-reflow. Am J Physiol 266: H1316-H1321
13. Jerome SN, Akimitsu T, Korthuis RJ (1994) Leukocyte adhesion, edema, and development of postischemic capillary no reflow. Am J Physiol 267: H1329-H1336
14. Juneau CF, Ito BR, Balzo U del, Engler RL (1993) Severe neutrophil depletion by leukocyte filters or cytotoxic drugs does not improve recovery of contractile function in stunned porcine myocardium. Cardiovasc Res 27: 720-727
15. Kraemer R, Mullane KM (1989) Neutrophils delay functional recovery of the post-hypoxic heart of the rabbit. J Pharmacol Exp Ther 251: 620-626
16. Kupatt C, Zahler S, Seligmann C, Massoudy P, Becker BF, Gerlach E (1996) Nitric oxide mitigates leukocyte adhesion and vascular leak after myocardial ischemia. J Mol Cell Cardiol 28: 643-654
17. Kupatt C, Habazettl H, Zahler S, Kowalski C, Becker BF, Messmer K, Gerlach E (1996) Venular adhesion of PMN in isolated guinea-pig hearts: influence of ischemia and reperfusion (abstract). Pflügers Arch 431 (Suppl.6) R43
18. Ley K (1992) Leukocyte adhesion - molecular basis and physiological consequences. Clin Hemorheol 12: 93-108
19. Mazzoni MC, Warnke KC, Arfors KE, Skalak TC (1994) Capillary hemodynamics in hemorrhagic shock and reperfusion: in vivo and model analysis. Am J Physiol 267: H1928-H1935
20. Mullane KM, Young M (1992) The contribution of neutrophil activation and changes in endothelial function to myocardial ischemia reperfusion injury. In: Yellon DM, Jennings RB (eds) Myocardial protection: the pathophysiology of reperfusion and reperfusion injury. Raven Press, New York, pp 59-83
21. Peeters LLH, Grutters G, Martin CB Jr (1980) Distribution of cardiac output in the unstressed pregnant guinea-pig. Am J Obstet Gynecol 138: 1177-1184
22. Potter RF, Groom AC (1983) Capillary diameter and geometry in cardiac and skeletal muscle studied by means of corrosion casts. Microvasc Res 25: 68-84
23. Raschke P, Becker BF (1995) Adenosine and PAF dependent mechanisms lead to myocardial reperfusion injury by neutrophils after brief ischaemia. Cardiovasc Res 29: 569-576
24. Raschke P, Becker BF, Leipert B, Schwartz LM, Zahler S, Gerlach E (1993) Postischemic dysfunction of the heart induced by small numbers of neutrophils via formation of hypochlorous acid. Bas Res Cardiol 88: 321-339
25. Schneeberger H, Illner WD, Abendroth D, Bulkley G, Rutili F, Williams M, Thiel M, Land W (1989) First clinical experiences with superoxide dismutase in kidney transplantation - resuits of a double-blind randomized study. Transplant Proc 21: 1245-1246
26. Shandelya S, Kuppusamy P, Weisfeld ML, Zweier JL (1993) Evaluation of the role of polymorphonuclear leukocytes on contractile function in myocardial reperfusion injury. Evidence for plasma-mediated leukocyte activation. Circulation 87: 536-546
27. Sutton DW, Schmid-Schönbein GW (1992) Elevation of organ resistance due to leukocyte perfusion. Am J Physiol 262: H1646-H1650
28. Toborg M. (1972) Zur Kenntnis der terminalen Strombahn im Myocard von Ratte und Katze. Z Zellforsch Mikrosk Anat 123: 369-394
29. Utley J, Carlson EL, Hoffman JIE, Martinez, HM, Buckberg GD (1974) Total and regional myocardial flow measurements with 25 μ, 15 μ, 9 μ, and filtered 1-10 μ diameter microspheres and antipyrine in dogs and sheep. Circ Res 34: 391-405
30. Warnke KC, Skalak TC (1990) The effects of leukocytes on blood flow in a model skeletal muscle capillary network. Microvasc Res 40: 118-136
31. Zahler S, Becker BF, Raschke P, Gerlach E (1994) Stimulation of endothelial adenosine A1 receptors enhances adhesion of neutrophils in the intact guinea pig coronary system. Cardiovasc Res 28: 1366-1372
32. Zahler S, Kowalski C, Brosig A, Kupatt C, Becker BF, Gerlach E (1997) The function of neutrophils isolated by a magnetic antibody cell separation technique is not altered in comparison to a density gradient centrifugation method. J Immunol Methods (in press)