Effects of α2-adrenergic agonists on lipopolysaccharide-induced aqueous flare elevation in pigmented rabbits

Japanese Journal of Ophthalmology

Volumn 45, Issue 3, 2001, Pages 221-226

  Watanabe, Kazuhiko ^a   Hayasaka, Seiji ^a   Hiraki, Shigeyoshi ^a   Matsumoto, Masayuki ^a   Kadoi, Chiharu ^a   Nagaki, Yasunori ^a  

^a TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Apraclonidine; Aqueous flare elevation; Clonidine; Guanfacine; Lipopolysaccharide

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; APRACLONIDINE; CLONIDINE; GUANFACINE; LIPOPOLYSACCHARIDE; YOHIMBINE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; UVEITIS;

ADMINISTRATION, TOPICAL; ADRENERGIC ALPHA-AGONISTS; ANIMALS; AQUEOUS HUMOR; AREA UNDER CURVE; CLONIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; GUANFACINE; LIPOPOLYSACCHARIDES; MALE; OPHTHALMIC SOLUTIONS; RABBITS; UVEITIS, ANTERIOR; YOHIMBINE;

EID: 0035011738     PISSN: 00215155     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-5155(00)00386-5     Document Type: Article

References (19)

1. 2 adrenergic receptors. Biochem Pharmacol. 55:1998;1035-1043.
2. Allen R.C., Langham M.E. The intraocular pressure response of conscious rabbits to clonidine. Invest Ophthalmol. 15:1976;815-823.
3. Yüksel N., Güler C., Çaglar Y., Elibol O. Apraclonidine and clonidine. a comparison of efficacy and side effects in normal and ocular hypertensive volunteers Int Ophthalmol. 16:1992;337-342.
4. Schwartzenberg G.W.S., Buys Y.M. Efficacy of brimonidine 0.2% as adjunctive therapy for patients with glaucoma inadequately controlled with otherwise maximal medical therapy. Ophthalmology. 106:1999;1616-1620.
5. Chevrier R.L., Assalian A., Duperré J., Lesk M.R. Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures. Ophthalmic Surg Lasers. 30:1999;199-204.
6. Araie M., Ishi K. Effects of apraclonidine on intraocular pressure and blood-aqueous barrier permeability after phacoemulsification and intraocular lens implantation. Am J Ophthalmol. 116:1993;67-71.
7. Sterk C.C., Renzenbrink-Bubberman A.C., van Best J.A. The effect of 1% apraclonidine on intraocular pressure after cataract surgery. Ophthalmic Surg Lasers. 29:1998;472-475.
8. Holsapple M.P., Malave A., Lowy M.T., Yim G.K.W. Central and peripheral anti-inflammatory actions by clonidine and a structurally related imidazoline analog. J Pharmacol Exp Ther. 229:1984;399-403.
9. Kulkarni S.K., Mehta A.K., Kunchandy J. Anti-inflammatory actions of clonidine, guanfacine and B-HT920 against various inflammagen-induced acute paw oedema in rats. Arch Int Pharmacodyn. 279:1986;324-334.
10. Sugiyama K., Kitazawa Y., Kawai K. Apraclonidine effects on ocular responses to YAG laser irradiation to the rabbit iris. Invest Ophthalmol Vis Sci. 31:1990;708-714.
11. Bonomi L., Bellucci R., Pagliarusco A., Stefani L. Apraclonidine protection of the blood-aqueous barrier from traumatic break-down. J Ocul Pharmacol. 11:1995;25-35.
12. Sobaci G., Mutlu F.M., Söyler M., Tatar T., Yildirim E. Effect of apraclonidine on blood-aqueous barrier. Ann Ophthalmol. 31:1999;176-179.
13. Hirata H., Hiraki S., Kaji Y., Takeda N., Fukuo Y., Tachinami K. The effects of transcorneal administration of prostaglandin E2 on rabbit eyes. Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc). 98:1994;927-934.
14. Watanabe K., Hayasaka S., Hiraki S.et al. Effects of topical clonidine on prostaglandin E2-induced aqueous flare elevation in pigmented rabbits. Ophthalmic Res. 32:2000;210-214.
15. Sawa M., Tsurimaki Y., Tsuru T., Shimizu H. New quantitative method to determine protein concentration and cell number in aqueous in vivo. Jpn J Ophthalmol. 32:1988;132-142.
16. Yano H., Hiraki S., Hayasaka S. Effects of Kakkon-to and Sairei-to on experimental elevation of aqueous flare in pigmented rabbits. Jpn J Ophthalmol. 43:1999;279-284.
17. Howes E.L. Jr., Goldyne M.E., Perez H.D., Goldstein I.M., Rosenbaum J.T. Lipopolysaccharide tolerance inhibits eye inflammation. Arch Ophthalmol. 103:1985;257-260.
18. Rosenbaum J.T., McDevitt H.O., Guss R.B., Egbert P.R. Endotoxin-induced uveitis in rats as a model for human disease. Nature. 286:1980;611-613.
19. Bhattacherjee P., Williams R.N., Eakins K.E. An evaluation of ocular inflammation following the injection of bacterial endotoxin into the rat foot pad. Invest Ophthalmol Vis Sci. 24:1983;196-202.