Effects of topical clonidine on prostaglandin-E2-induced aqueous flare elevation in pigmented rabbits

Ophthalmic Research

Volumn 32, Issue 5, 2000, Pages 210-214

  Watanabe, Kazuhiko ^a   Hayasaka, Seiji ^a   Hiraki, Shigeyoshi ^a   Matsumoto, Masayuki ^a   Kadoi, Chiharu ^a   Nagaki, Yasunori ^a   Hayasaka, Yoriko ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Aqueous flare elevation; Clonidine; Pigmented rabbits; Prostaglandin E2; Yohimbine

Indexed keywords

CLONIDINE; PROSTAGLANDIN E2; YOHIMBINE;

ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; EYE INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RABBIT;

EID: 0033828202     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000055615     Document Type: Article

References (16)

1. 2-adrenoceptors in the ventrolateral medulla. Eur J Pharmacol 1987;134:1-13.
2. Hoobler SW, Sagastume E: Clonidine hydrochloride in the treatment of hypertension. Am J Cardiol 1971;28:67-73.
3. Timmersmans PBMWM, Schoop AMC, Kwa HY, van Zwieten PA: Characterization of α-adrenoreceptors participating in the central hypotensive and sedative effects of clonidine using yohimbine, rauwolscine and corynanthine. Eur J Pharmacol 1981;70:7-15.
4. Ernsberger P, Giuliano R, Willette RN, Granata AR, Reis DJ: Hypotensive action of clonidine analogues correlated with binding affinity at imidazoline and not alpha-2-adrenergic receptors in the rostral ventrolateral medulla. J Hypertens 1988;6(suppl 4):S554-S557.
5. Allen RC, Langham ME: The intraocular pressure response of conscious rabbits to clonidine. Invest Ophthalmol 1976;15:815-823.
6. Innemee HC, van Zwieten PA: The central ocular hypertensive effect of clonidine. Graefes Arch Ophthalmol 1979;210:93-102.
7. Hodapp E, Kolker AE, Kass MA, Goldberg I, Becker B, Goldon M: The effect of topical clonidine on intraocular pressure. Arch Ophthalmol 1981;99:1208-1211.
8. Lee DA, Topper JE, Brubaker RF: Effect of clonidine on aqueous humor flow in normal human eyes. Exp Eye Res 1984;38:239-246.
9. Yüksel N, Güler C, Çagplar Y, Elibol O: Apraclonidine and clonidine: A comparison of efficacy and side effects in normal and ocular hypertensive volunteers. Int Ophthalmol 1992; 16:337-342.
10. Moriwaki Y, Iizuka T, Nakamura A, Nakata K, Masaoka Y, Ueda T, Koide R, Inatomi M, Fukado Y, Uchida E, Oguchi K, Yasuhara H, Hisamitsu T, Takeshige C: Ocular hypotensive effect of α-adrenoceptor agonist and antagonist in the conscious pigmented rabbit. Acta Soc Ophthalmol Jpn 1992;96:152-160.
11. Groh MJ, Michelson G, Groh ME, Gründler AE: Ocular macro-and microcirculation after topical application of clonidine and metipranolol. Ger J Ophthalmol 1994;3:175-178.
12. Holsapple MP, Malave A, Lowy MT, Yim GKW: Central and peripheral anti-inflammatory actions by clonidine and a structurally related imidazoline analog. J Pharmacol Exp Ther 1984;229:399-403.
13. Sugiyama K, Kitazawa Y, Kawai K: Aproclonidine effects on ocular responses to YAG laser irradiation to the rabbit iris. Invest Ophthalmol Vis Sci 1990;31:708-714.
14. Bonomi L, Bellucci R, Pagliarusco A, Stefani L: Apraclonidine protection of the blood-aqueous barrier from traumatic break-down. J Ocul Pharmacol 1995;11:25-35.
15. 2 on rabbit eyes. J Jpn Ophthalmol Soc 1994;98:927-934.
16. Sawa M, Tsurimaki Y, Tsuru T, Shimizu H: New quantitative method to determine protein concentration and cell number in aqueous in vivo. Jpn J Ophthalmol 1988;32:132-142.