Endothelial E- and P-selectin expression in iNOS-deficient mice exposed to polymicrobial sepsis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 280, Issue 2 43-2, 2001, Pages

  Lush, Cameron W ^b   Cepinskas, Gediminas ^b   Sibbald, William J ^b   Kvietys, Peter R ^a  

^a LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^b NONE

Author keywords

Cecal ligation and perforation; Intracellular adhesion molecule 2; Myeloperoxidase activity; Neutrophils

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; MYELOPEROXIDASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PADGEM PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME REGULATION; INTESTINE PERFORATION; LEUKOCYTE; LUNG; LUNG CIRCULATION; MALE; MOUSE; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYSTEMIC CIRCULATION;

EID: 0035010643     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2001.280.2.g291     Document Type: Article

References (31)

1. Bauer P, Lush CW, Kvietys PR, Russell JM, and Granger DN. Role of endotoxin in the expression of endothelial selectins after cecal ligation and perforation. Am J Physiol Regulatory Integrative Comp Physiol 278: R1140-R1147, 2000.
2. Bauer P, Russell J, and Granger DN. Role of endotoxin in intestinal reperfusion-induced expression of E-selectin. Am J Physiol Gastrointest Liver Physiol 276: G479-G484, 1999.
3. Bullard DC, Kunkel EJ, Kubo H, Hicks MJ, Lorenzo I, Doyle NA, Doerschuk CM, Ley K, and Beaudet AL. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp Med 183: 2329-2336, 1996.
4. Bullard DC, Qin L, Lorenzo I, Quinlin WM, Doyle NA, Bosse R, Vestweber D, Doerschuk CM, and Beaudet AL. P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal into pulmonary alveoli. J Clin Invest 95: 1782-1788, 1995.
5. Cepinskas G, Lush CW, and Kvietys PR. Anoxia/reoxygenation-induced tolerance with respect to polymorphonuclear leukocyte adhesion to cultured endothelial cells - a nuclear factor-κB-mediated phenomenon. Circ Res 84: 103-112, 1999.
6. De Caterina R, Libby P, Peng HB, Thannickal VJ, Rajavashisth TB, Gimbrone MA Jr, Shin WS, and Liao JK. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest 96: 60-68, 1995.
7. Doerschuk CM, Mizgerd JP, Kubo H, Qin L, and Kumasaka T. Adhesion molecules and cellular biomechanical changes in acute lung injury. Chest 116: 37S-43S, 1999.
8. Eppihimer MJ, Russell J, Anderson DC, Epstein CJ, Laroux S, and Granger DN. Modulation of P-selectin expression in the postischemic intestinal microvasculature. Am J Physiol Gastrointest Liver Physiol 273: G1326-G1332, 1997.
9. Eppihimer MJ, Wolitzky B, Anderson DC, Labow MA, and Granger DN. Heterogeneity of expression of E- and P-selectins in vivo. Circ Res 79: 560-569, 1996.
10. Haraldsen G, Kvale D, Lien B, Farstad IN, and Brandtzaeg P. Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells. J Immunol 156: 2558-2565, 1996.
11. Hickey MJ, Sharkey KA, Sihota EG, Reinhardt PH, Macmicking JD, Nathan C, and Kubes P. Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia. FASEB J 11: 955-964, 1997.
12. Kanwar S and Kubes P. Nitric oxide is an antiadhesive molecule for leukocytes. New Horiz 3: 93-104, 1995.
13. Labow MA, Norton CR, Rumberger JM, Lombard-Gillooly KM, Shuster DJ, Hubbard J, Bertko R, Knaack PA, Terry RW, and Harbison ML. Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Immunity 1: 709-720, 1994.
14. Langley RR, Russell J, Eppihimer M, Alexander SJ, Gerritsen M, Specian RD, and Granger DN. Quantification of murine endothelial cell adhesion molecules in solid tumors. Am J Physiol Heart Circ Physiol 277: H1156-H1166, 1999.
15. Lush CW, Cepinskas G, and Kvietys PR. LPS tolerance in human endothelial cells: reduced PMN adhesion, E-selectin expression, and NF-κB mobilization. Am J Physiol Heart Circ Physiol 278: H853-H861, 2000.
16. Lush CW and Kvietys PR. Microvascular dysfunction in sepsis. Microcirculation 7: 83-101, 2000.
17. Mayadas TN, Johnson RC, Rayburn H, Hynes RO, and Wagner DD. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 74: 541-554, 1993.
18. McCafferty DM, Mudgett JS, Swain MG, and Kubes P. Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation. Gastroenterology 112: 1022-1027, 1997.
19. Mercer-Jones MA, Heinzelmann M, Peyton JC, Wickel D, Cook M, and Cheadle WG. Inhibition of neutrophil migration at the site of infection increases remote organ neutrophil sequestration and injury. Shock 8: 193-199, 1997.
20. Neviere RR, Cepinskas G, Madorin WS, Hoque N, Karmazyn M, Sibbald WJ, and Kvietys PR. LPS pretreatment ameliorates peritonitis-induced myocardial inflammation and dysfunction: role of myocytes. Am J Physiol Heart Circ Physiol 277: H885-H892, 1999.
21. Ou J, Carlos TM, Watkins SC, Saavedra JE, Keefer LK, Kim YM, Harbrecht BG, and Billiar TR. Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia. Nitric Oxide 1: 404-416, 1997.
22. Palazzo AJ, Jones SP, Anderson DC, Granger DN, and Lefer DJ. Coronary endothelial P-selectin in pathogenesis of myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 275: H1865-H1872, 1998.
23. Panes J and Granger DN. Leukocyte-endothelial cell interactions: molecular mechanisms and implications in gastrointestinal disease. Gastroenterology 114: 1066-1090, 1998.
24. Panes J, Perry M, and Granger DN. Leukocyte-endothelial cell adhesion: avenues for therapeutic intervention. Br J Pharmacol 126: 537-550, 1999.
25. Russel J, Lefer DJ, Grisham MB, and Granger DN. iNOS-derived NO mediates ischemia-reperfusion induced E-selectin expression in murine small intestine (Abstract). Gastroenterology 116: A924, 2000.
26. Spiecker M, Darius H, Kaboth K, Hubner F, and Liao JK. Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants. J Leukoc Biol 63: 732-739, 1998.
27. Spiecker M, Peng HB, and Liao JK. Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IκBα. J Biol Chem 272: 30969-30974, 1997.
28. Takahashi M, Ikeda U, Masuyama J, Funayama H, Kano S, and Shimada K. Nitric oxide attenuates adhesion molecule expression in human endothelial cells. Cytokine 8: 817-821, 1996.
29. Webert K, Vanderzwan J, Duggan M, Scott J, McCormack D, Lewis J, and Mehta S. Effects of inhaled nitric oxide in a rat model of Pseudomonas aeruginosa pneumonia. Crit Care Med 28: 2397-2405, 2000.
30. Wickel DJ, Mercer-Jones M, Peyton JC, Shrotri MS, and Cheadle WG. Neutrophil migration into the peritoneum is P-selectin dependent, but sequestration in lungs is selectin independent during peritonitis. Shock 10: 265-269, 1998.
31. Xu H, Bickford JK, Luther E, Carpenito C, Takei F, and Springer TA. Characterization of murine intercellular adhesion molecule-2. J Immunol 156: 4909-4914, 1996.