Estrone, but not 17β-estradiol, attenuates kainate-induced seizures and toxicity in male mice

Experimental and Clinical Endocrinology and Diabetes

Volumn 109, Issue 3, 2001, Pages 168-173

  Budziszewska, B ^a   Leskiewicz M ^a   Kubera, M ^a   Jaworska Feil, L ^a   Kajta, M ^a   Lason W ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

17 Estradiol; Estrone; Immunoreactivity; Kainate; Mice; Neurotoxicity; Seizures

Indexed keywords

ANTICONVULSIVE AGENT; ANTIESTROGEN; ESTRADIOL; ESTRONE; KAINIC ACID; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CLONIC SEIZURE; CONTROLLED STUDY; ESTROGEN ACTIVITY; HIPPOCAMPUS; MALE; MORTALITY; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; THYMUS;

ANIMALS; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTRONE; HIPPOCAMPUS; IMMUNITY; KAINIC ACID; MALE; MICE; NEURONS; SEIZURES; TAMOXIFEN;

EID: 0035007037     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2001-14841     Document Type: Article

References (31)

1. Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus
2. Epileptic seizures in women related to plasma estrogen and progesterone during the menstrual cycle
3. 17beta-estradiol protects neurons from oxidative stress-induced cell death in vitro
4. Evidence suggesting secondary epileptogenic lesions after kainic acid: Pretreatment with diazepam reduced distant but not local damage
5. Immunological parameters in patients with epilepsy
6. Estradiol replacement to female rats facilitates dorsal hippocampal but not ventral hippocampal kindled seizure acquisition
7. Immunohistochemical localisation of interleukin-1beta, interleukin-1 receptor antagonist and interleukin-1beta converting enzyme/caspase-1 in the rat brain after peripheral administration of kainic acid
8. Rapid action of 17beta-estradiol on kainate-induced currents in hippocampal neurons lacking intracellular estrogen receptors
9. Biphasic effect of estrogen on neuronal constitutive nitric oxide synthase via Ca2+-calmodulin dependent mechanism
10. Have we underestimated the importance of the thymus in man?
11. Effect of repeated amitriptyline administration to mice on the T lymphocyte proliferative activity and natural killer cell cytotoxicity
12. Sex steroids and 5-en-3β-hydroxy steroids in specific regions of the human brain and cranial nerves
13. Electrocortical activation by estrogens
14. The role of estrogens in catmenial exacerbation of epilepsy
15. Effect of hypothalamic lesion or chemical axotomy on restitution of immunoreactivity in mice after cyclophosphamide administration
16. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor
17. The effects of lesions in the lateral septal and hippocampal areas on the humoral immune response of adult female rats
18. Comparative effects of estradiol benzoate, the antiestrogen clomiphene citrate, and the progestin medroxyprogesterone acetate on kainic acid-induced seizures in male and female rats
19. Damage induced by systemic kainic acid in rats is dependent upon seizure activity - A behavioral and morphological study
20. Estrogens attenuate neuronal injury due to hemoglobin, chemical hypoxia and excitatory amino acids in murine cortical cultures
21. Neuroprotective effects of chronic estradiol benzoate treatment on hippocampal cell loss induced by status epilepticus in the female rat
22. A receptors in the dorsal hippocampus by estradiol and progesterone
23. Steroid hormone effects on picrotoxin-induced seizures in female and male rats
24. Estrogen protects primary cortical neurons from glutamate toxicity
25. Sex steroid effects on extrahypothalamic CNS I. Estrogen augments neuronal responsiveness to iontophoretically applied glutamate in the cerebellum
26. Region-specific modulation of limbic seizure susceptibility by ovarian steroids
27. Estradiol selectively regulates agonist binding sites on the N-methyl-D-aspartate receptor complex in the CA1 region of the hippocampus
28. Effects of sex hormone manipulation on audiogenic seizures
29. The effect of kainic acid-induced lesions in the lateral septal area on cell-mediated immune function
30. The gonad-brain relationship: Effects of female sex hormones on electroshock convulsions in the rat
31. Glutamate receptor requirement for neuronal death from anoxia-reoxygenation: An in vitro model for assessment of the neuroprotective effects of estrogens