Freeze drying properties of some oligonucleotides

Pharmaceutical Development and Technology

Volumn 6, Issue 2, 2001, Pages 151-157

  Jameel, Feroz ^c   Amsberry, Kent L ^a   Pikal, Michael J ^b  

^a Medicines Company   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c NONE

Author keywords

Freeze drying; Modulated DSC; Oligonucleotides

Indexed keywords

GLASS; LACTOSE; OLIGONUCLEOTIDE;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG STABILITY; DRUG STRUCTURE; FREEZE DRYING; HUMIDITY; PHASE SEPARATION; PRIORITY JOURNAL; TEMPERATURE SENSITIVITY; THERMOGRAPHY;

CALORIMETRY, DIFFERENTIAL SCANNING; FREEZE DRYING; OLIGONUCLEOTIDES; TEMPERATURE;

EID: 0035004725     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100000743     Document Type: Article

References (10)

1. Inhibition of rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide
2. Progress in antisense therapeutics
3. Antisense oligonucleotides: Towards clinical trials
4. Antisense oligonucleotides as therapeutics for malignant disease
5. Mixed backbone oligonucleotides as second generation antisense oligonucleotides: In vitro and in vivo studies
6. Physical chemistry of freeze-drying: Measurement of sublimation rates for frozen aqueous solutions by a micro balance technique
7. An improved microscope stage for direct observation of freezing and freeze drying
8. The physico-chemical basis for the freeze-drying process
9. The effect of temperature on water vapor sorption by some amorphous pharmaceutical sugars
10. Process control in freeze-drying: Determination of the end point of sublimation drying by an electronic moisture sensor