Toward clinical application of prompt gamma spectroscopy for in vivo monitoring of boron uptake in boron neutron capture therapy

Medical Physics

Volumn 28, Issue 5, 2001, Pages 787-795

  Munck Af Rosenschold P M ^a   Verbakel, W F A R ^b   Ceberg, C P ^a   Stecher Rasmussen, F ^b   Persson, B R R ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b NUCLEAR RESEARCH AND CONSULTANCY GROUP NRG   (Netherlands)

Author keywords

BNCT; Boron measurements; Gamma ray telescope; In vivo dosimetry; Prompt gamma spectroscopy

Indexed keywords

BLOOD VESSELS; MEDICAL APPLICATIONS; PHANTOMS; TUMORS; ULTRAVIOLET SPECTROSCOPY; UNCERTAINTY ANALYSIS;

BNCT; BORON CONCENTRATIONS; BORON NEUTRON CAPTURE THERAPY; CLINICAL APPLICATION; GAMMA RAY TELESCOPE; IN-VIVO; MEASUREMENT PROCEDURES; PROMPT GAMMAS;

GAMMA RAYS;

BORON; BORON 10; DEUTERIUM; HYDROGEN; LITHIUM;

ARTICLE; DRUG MONITORING; DRUG UPTAKE; GAMMA RADIATION; GAMMA SPECTROMETRY; NEUTRON CAPTURE THERAPY; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE DISTRIBUTION;

EID: 0034999602     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.1367281     Document Type: Article

References (18)

1. E. H. Elowitz, R. M. Bergland, J. A. Coderre, D. D. Joel, M. Chadha, and A. D. Chanana, "Biodistribution of p-boronophenylalanine in patients with glioblastoma multiforme for use in boron neutron capture therapy," J. Neurosci. 42, 463-469 (1998).
2. C. P. Ceberg, A. Persson, A. Brun, R. Huiskamp, A.-S. Fyhr, B. R. R. Persson, and L. G. Salford, "Performance of BSH in patients with astrocytoma grades III-IV - a basis for boron neutron capture therapy," J. Neurosci. 83, 79-85 (1995).
3. T. Kobayashi, Y. Sakurai, and M. Ishikawa, "A noninvasive dose estimation system for clinical BNCT based on PG-SPECT - Conceptual study and fundamental experiments using HPGe and CdTe semiconductor detectors," Med. Phys. 27, 2124-2132 (2000).
4. W. F. A. R. Verbakel and F. Stecher-Rasmussen, "A γ-ray telescope for on-line measurements of low boron concentrations in a head phantom for BNCT," Nucl. Instrum. Methods Phys. Res. A 394, 163-172 (1997).
5. 10boron analysis by prompt gamma ray spectroscopy," Phys. Med. Biol. 36, 329-338 (1991).
6. W. F. A. R. Verbakel and F. Stecher-Rasmussen, "On-line reconstruction of low boron concentrations by in-vivo spectroscopy for BNCT Physics in Medicine and Biology (2001, in press).
7. 10B concentration in tissue for neutron capture therapy by prompt gamma spectroscopy," Nucl. Instrum. Methods Phys. Res. 204, 525-531 (1983).
8. 10B concentration for boron neutron capture therapy using prompt gamma-ray analysis," Acta Oncol. 34, 517-523 (1995).
9. Brookhaven National Laboratory (BNL). http://www.dne.bnl.gov/CoN/ index.html.
10. R. C. West et al., The Handbook of Chemistry and Physics, 52nd ed. (The Chemical Rubber Company, Boca Raton, FL, 1971).
11. J. H. Hubbell, "Photon mass attenuation and energy-absorption coefficients from 1 keV to 20 MeV," Int. J. Appl. Radiat. Isot. 33, 1269-1290 (1982).
12. J. F. Briesmeister, MCNP - A General Monte Carlo N-Particle Transport Code, Version 4B, LA-12625-M, Los Alamos National Laboratory (1997).
13. 36Cl studied with non-polarized and polarized thermal neutrons," Nucl. Phys. A 264, 63-92 (1976).
14. D. Gabel, "Present status and perspectives of boron neutron capture therapy," Rad. Oncol. 30, 199-205 (1994).
15. The International Commission on Radiological Protection, Report of the Task Group on Reference Man (Pergamon, New York, 1974).
16. K. A. Rempp, G. Brix, F. Wenz, C. R. Becker, F. Gückel, and W. J. Lorenz, "Quantification of regional cerebral blood flow and volume with dynamic susceptibility contrast-enhanced MR imaging," Radiology 193, 637-641 (1994).
17. K. L. Leenders et al., "Cerebral blood flow, blood volume, and oxygen utilization," Brain 113, 27-47 (1990).
18. S.-J. Ye, "Boron self-shielding effects on dose delivery of neutron capture therapy using epithermal beam and boronophenylanine," Med. Phys. 26, 2488-2493 (1999).