A noninvasive dose estimation system for clinical BNCT based on PG-SPECT - Conceptual study and fundamental experiments using HPGe and CdTE semiconductor detectors

Medical Physics

Volumn 27, Issue 9, 2000, Pages 2124-2132

  Kobayashi, Tooru ^a   Sakurai, Yoshinori ^a   Ishikawa, Masayori ^b  

^a KYOTO UNIVERSITY   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Boron neutron capture therapy; CdTe semiconductor detector; Noninvasive system; Prompt gamma ray analysis; Single photon emission computed tomography

Indexed keywords

CADMIUM TELLURIDE; DOSIMETRY; GAMMA RAYS; GERMANIUM COMPOUNDS; II-VI SEMICONDUCTORS; NONINVASIVE MEDICAL PROCEDURES; PARTICLE BEAMS; PHOTONS; SEMICONDUCTING CADMIUM COMPOUNDS; SEMICONDUCTING CADMIUM TELLURIDE; SEMICONDUCTING GERMANIUM COMPOUNDS; SEMICONDUCTING TELLURIUM COMPOUNDS; SEMICONDUCTOR DETECTORS; UNCERTAINTY ANALYSIS;

ABSORBED DOSE DISTRIBUTION; BORON NEUTRON CAPTURE THERAPY; FUNDAMENTAL EXPERIMENTS; NONINVASIVE SYSTEM; PROMPT GAMMAS; STATISTICAL UNCERTAINTY; THERMAL-NEUTRON FLUX; THREE-DIMENSIONAL (3D) IMAGING SYSTEMS;

SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY;

BORON 10; CADMIUM; GERMANIUM; HYDROGEN; LITHIUM; TELLURIUM;

ARTICLE; DOSE CALCULATION; DOSIMETRY; GAMMA RADIATION; HUMAN; IMAGING SYSTEM; MEASUREMENT; NEUTRON CAPTURE THERAPY; PRIORITY JOURNAL; RADIATION DOSE DISTRIBUTION; SEMICONDUCTOR; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THREE DIMENSIONAL IMAGING; TREATMENT PLANNING; TUMOR VOLUME;

EID: 0033795948     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.1288243     Document Type: Article

References (29)

1. H. Hatanaka and K. Sano, "A revised boron-neutron capture therapy for malignant brain tumors. I. Experience on terminally ill patients after cobalt-60 radiotherapy," Z. Neurol. 204, 309-332 (1973).
2. H. Hatanaka, "Clinical results of boron neutron capture therapy," in Neutron Beam Design, Development, and Performance for Neutron Capture Therapy, edited by O. K. Harling et al. (Plenum, New York, 1990), pp. 15-21.
3. 10B-compound," Lancet II, 388-389 (1989).
4. K. Kanda, T. Kobayashi, K. Ono, T. Sato, T. Shibata, Y. Ujeno, Y. Mishima, H. Hatanaka, and Y. Nishiwaki, "Elimination of gamma rays from a thermal neutron field for medical and biological irradiation Purposes," Biomedical Dosimetry, IAEA, 205-223 (1976).
5. T. Kobayashi, K. Kanda, Y. Ujeno, and M. R. Ishida, "Biomedical irradiation system for boron neutron capture therapy at the Kyoto University reactor," in Ref. 2, pp. 321-339.
6. K. Kanda, T. Kobayashi, M. Takeuchi, and S. Ouchi, "Development of neutron shielding material using LiF," Proceedings of the 6th International Conference on Radiation Shielding, 6th ICRS Vol. II, JAERI (1984), pp. 1258-1265.
7. 10B concentrations in tissue for neutron capture therapy by prompt gamma-ray spectrometry," Nucl. Instrum. Methods Phys. Res. 204, 525-531 (1983).
8. K. Aoki, T. Kobayashi, and K. Kanda, "Phantom experiment and analysis for in vivo measurement of boron-10 concentrations in melanoma for boron neutron capture therapy," J. Nucl. Sci. Technol. 21, 647-656 (1984).
9. 10B concentrations and absorbed dose estimations in human malignant melanoma treated by BNCT," Strahlenther. Onkol. 165, 104-106 (1989).
10. T. Kobayashi and K. Kanda, "Analytical calculation of boron-10 dosage in cell nucleus for neutron capture therapy," Radiat. Res. 91, 77-94 (1982).
11. K. Ono, S. Ueda, Y. Oda, Y. Nakagawa, S. Miyatake, M. Takagaki, M. Osawa, and T. Kobayashi, "Boron neutron capture therapy for malignant glioma at Kyoto University Reactor," in Advances in Neutron Capture Therapy, edited by B. Larsson et al. (Elsevier Science, Amsterdam, 1997), Vol. I, pp 39-45.
12. Y. Nakagawa and H. Hatanaka, "Boron neutron capture therapy -Clinical brain tumor studies," J. Neuro-Oncol. 33, 105-115 (1997).
13. 10B-paraboronophenylalanine with special reference to evaluation of radiation dose and damage to the normal skin," Radiat. Res. 138, 435-442 (1994).
14. Y. Imahori, S. Ueda, Y. Ohmori, N. Kobori, K. Sakae, T. Kusuki, T. Kobayashi, M. Takagaki, K. Ono, T. Ido, and R. Fujii, "Positron emission tomography-based boron neutron capture therapy using boronophenylealanine for high-grade gliomas: Part I," Clin. Cancer Res. 4, 1825-1832 (1998).
15. T. Kobayashi, K. Kanda, Y. Fujita, Y. Sakurai, and K. Ono, "The upgrade of the havy water facility of the Kyoto University reactor for neutron capture therapy," in Ref. 11, pp. 321-325.
16. Y. Sakurai, T. Kobayashi, K. Kanda, and K. Ono, "The irradiation characteristics of the upgraded heavy water facility of the Kyoto University reactor," in Ref. 11, pp. 316-320.
17. R. J. Jaszczak, R. E. Coleman, and Chun Bin Lim, "SPECT: Single photon emission computed tomography," IEEE Trans. Nucl. Sci. 27(3), 1137-1153 (1980).
18. G. L. Locher, "Biological effects and therapeutic possibilities of neutrons," Am. J. Roentgenol. Radium Ther. 36, 1-13 (1936).
19. W. S. Synder, M. J. Cook, E. S. Nasset, L. R. Kahrhausen, G. P. Howells, and L. H. Tipon, Report of the Task Group on Reference Man (Pergamon, Oxford, 1975).
20. R. S. Caswell, J. J. Coyne, and M. L. Randolph, "Kerma factors for neutron energies below 30 MeV," Radiat. Res. 83, 217-254 (1980).
21. J. H. Hubbell, "Photon cross sections, attenuation coefficients, and energy absorption coefficients from 10 keV to 100 GeV," NSRDS-NBS 29 (1969).
22. W. F. A. R. Verbakel and F. M. Stecher-Rasmussen, "A gamma ray telescope for on-line measurements of low boron concentrations in a head phantom for BNCT," Nucl. Instrum. Methods Phys. Res. A 394, 163-172 (1997).
23. K. Way, Nuclear Data Tables, Section A 6(7) (Academic, New York, 1970).
24. New Material Handbook Editorial Committee, New Material Handbook (in Japanese), Maruzen, Tokyo, 1988, p. 321.
25. E. Sakai, Y. Murakami, and H. Nakatani, "Performance of a high-purity Ge gamma-ray spectrometer system using a closed-cycle cryogenic refrigerator," IEEE Trans. Nucl. Sci. NS-29, 760-763 (1982).
26. R. E. Stone, V. A. Barkley, and J. A. Fleming, "Performance of a gamma-ray and x-ray spectrometer utilizing germanium and Si(Li) detectors cooled by a closed-cycle cryogenic mechanical refrigerator," IEEE Trans. Nucl. Sci. NS-33, 299-302 (1986).
27. W. Akutagawa and K. Zanio, "Gamma response of semi-insulating material in the presence of trapping and detrapping," J. Appl. Phys. 40, 3838-3854 (1969).
28. P. N. Luke and E. E Eissler, "Performance of CdZnTe coplanar grid gamma-ray detector," IEEE Trans. Nucl. Sci. 43, 1481-1486 (1995).
29. Cs. Szeles, Y. Y. Shan, K. G. Lynn, and E. E. Eissler, "Deep electronic levels in high pressure bridgman CdlxZnxTe," Nucl. Instrum. Methods Phys. Res. A 380, 148-152 (1996).